Match!
Maya Schuldiner
Weizmann Institute of Science
Molecular biologyEndoplasmic reticulumSaccharomyces cerevisiaeBiologyCell biology
136Publications
35H-index
7,973Citations
What is this?
Publications 157
Newest
#1Emma Fenech (Weizmann Institute of Science)H-Index: 4
#2Shifra Ben-Dor (Weizmann Institute of Science)H-Index: 28
Last. Maya Schuldiner (Weizmann Institute of Science)H-Index: 35
view all 3 authors...
The evolution of eukaryotic genomes has been propelled by a series of gene duplication events, leading to an expansion in new functions and pathways. While duplicate genes may retain some functiona...
Source
#1Alexandria Colaco (University of Oxford)H-Index: 6
#2María E. Fernández‐Suárez (University of Oxford)H-Index: 1
Last. Forbes D. Porter (NIH: National Institutes of Health)H-Index: 45
view all 14 authors...
Niemann–Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the NPC1 or NPC2 genes. Mutations in the NPC1 gene lead to the majority of clinical cases (95%); however, the function of NPC1 remains unknown. To gain further insights into the biology of NPC1, we took advantage of the homology between the human NPC1 protein and its yeast orthologue, Niemann–Pick C–related protein 1 (Ncr1). We recreated the NCR1 mutant in yeast and performed screens to identify c...
Source
#1Yury S. Bykov (Weizmann Institute of Science)
#2Doron Rapaport (University of Tübingen)H-Index: 46
Last. Maya Schuldiner (Weizmann Institute of Science)H-Index: 35
view all 4 authors...
While targeting of proteins synthesized in the cytosol to any organelle is complex, mitochondria present the most challenging of destinations. First, import of nuclear-encoded proteins needs to be balanced with production of mitochondrial-encoded ones. Moreover, as mitochondria are divided into distinct subdomains, their proteins harbor a number of different targeting signals and biophysical properties. While translocation into the mitochondrial membranes has been well studied, the cytosolic ste...
Source
#1Yaxi Wang (A&M: Texas A&M University)H-Index: 1
#2Peihua Yuan (Texas A&M Health Science Center)
Last. Sin Man Lam (CAS: Chinese Academy of Sciences)
view all 12 authors...
The yeast phosphatidylserine (PtdSer) decarboxylase Psd2 is proposed to engage in a membrane contact site (MCS) for PtdSer decarboxylation to phosphatidylethanolamine (PtdEtn). This proposed MCS harbors Psd2, the Sec14-like phosphatidylinositol transfer protein (PITP) Sfh4, the Stt4 phosphatidylinositol (PtdIns) 4-OH kinase, the Scs2 tether, and an uncharacterized protein. We report that, of these components, only Sfh4 and Stt4 regulate Psd2 activity in vivo. They do so via distinct mechanisms. ...
Source
#1Naama Zung (Weizmann Institute of Science)
#2Maya Schuldiner (Weizmann Institute of Science)H-Index: 35
Contact sites, areas where two organelles are held in close proximity through the action of molecular tethers, enable non-vesicular communication between compartments. Mitochondria have been center stage in the contact site field since the discovery of the first contact between mitochondria and the endoplasmic reticulum (ER) over 60 years ago. However, only now, in the last decade, has there been a burst of discoveries regarding contact site biology in general and mitochondrial contacts specific...
Source
#1SreeDivya Saladi (TUK: Kaiserslautern University of Technology)
#2Felix Boos (TUK: Kaiserslautern University of Technology)H-Index: 4
Last. Johannes M. Herrmann (TUK: Kaiserslautern University of Technology)H-Index: 51
view all 10 authors...
Summary The proteolytic turnover of mitochondrial proteins is poorly understood. Here, we used a combination of dynamic isotope labeling and mass spectrometry to gain a global overview of mitochondrial protein turnover in yeast cells. Intriguingly, we found an exceptionally high turnover of the NADH dehydrogenase, Nde1. This homolog of the mammalian apoptosis inducing factor, AIF, forms two distinct topomers in mitochondria, one residing in the intermembrane space while the other spans the outer...
1 CitationsSource
O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM) that ends futile folding cycles and saves cellular resources is mainly mediated by protein O-mannosyltransferases Pmt1 and Pmt2. Here we describe a genetic screen for factors that influence O-mannosylation in yeas...
Source
#1Joan Castells-Ballester (Heidelberg University)H-Index: 2
#2Natalie Rinis (Heidelberg University)
Last. Sabine Strahl (Heidelberg University)H-Index: 22
view all 11 authors...
O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM) that ends futile folding cycles and saves cellular resources is mainly mediated by protein O-mannosyltransferases Pmt1 and Pmt2. Here we describe a genetic screen for factors that influence O-mannosylation in yeas...
Source
#1Jianhui Li (Yale University)
#2Michal Breker (Weizmann Institute of Science)H-Index: 10
Last. Mark Hochstrasser (Yale University)H-Index: 58
view all 5 authors...
The ubiquitin-proteasome system regulates numerous cellular processes and is central to protein homeostasis. In proliferating yeast and many mammalian cells, proteasomes are highly enriched in the nucleus. In carbon-starved yeast, proteasomes migrate to the cytoplasm and collect in proteasome storage granules (PSGs). PSGs dissolve and proteasomes return to the nucleus within minutes of glucose refeeding. The mechanisms by which cells regulate proteasome homeostasis under these conditions remain ...
2 CitationsSource
#1A. Galih Haribowo (University of Geneva)H-Index: 1
#2J. Thomas Hannich (University of Geneva)H-Index: 6
Last. Howard Riezman (University of Geneva)H-Index: 81
view all 7 authors...
Deoxysphingolipid toxicity has been examined in yeast, and it was revealed that C26 deoxydihydroceramides are most toxic and that the mechanism of toxicity involves changes in the actin cytoskeleto...
1 CitationsSource
12345678910