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Kyoko Ishiguro
Mukogawa Women's University
60Publications
24H-index
1,188Citations
Publications 60
Newest
#1Hisae Oku (Mukogawa Women's University)H-Index: 16
#2Emiko Iwaoka (Hyogo University of Health Sciences)H-Index: 8
Last.Kyoko Ishiguro (Mukogawa Women's University)H-Index: 24
view all 6 authors...
#1Chao Ma (SPU: Shenyang Pharmaceutical University)
#2Naoko Higashi (Mukogawa Women's University)
Last.Hisae Oku (Mukogawa Women's University)H-Index: 16
view all 8 authors...
Linarinic acid, (−)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid (4a), was isolated from the ethanol extract of Linaria vulgaris Mill. In our previous study, a series of tetrahydropyrrolo[2,1-b]quinazoline derivatives 4b, 4c, 5a, 5b, 6a and 6b that were structurally related to 4a and evaluated as neuroprotective agents were synthesized. The aim of the present study was to investigate the novel features of these compounds. We examined their allergy-preventive effects using an in ...
#1Masaki Hisano (Kobe University)H-Index: 2
#2Yuichi Uno (Kobe University)H-Index: 12
Last.Hiromichi Itoh (Kobe University)H-Index: 5
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Abstract The purpose of this research is to develop environmental control methods to realize rapid and high quality production of Hedyotis diffusa. Hedyotis diffusa has been used as herbal medicine and iridoid is a main medicinal property. In order to inspect the effect of light intensity on the concentration of iridoid in Hedyotis diffusa, the 2 experimental treatments were prepared by using a growth chamber; one was high intensity treatment (photon flux density of 170 μmol·s -1 ·m -2 ) and the...
#1Emiko Iwaoka (Mukogawa Women's University)H-Index: 8
#2Hisae Oku (Mukogawa Women's University)H-Index: 16
Last.Kyoko Ishiguro (Mukogawa Women's University)H-Index: 24
view all 4 authors...
Allergy-preventive activity was demonstrated for the MeOH extract (HM) of the petals of Hibiscus mutabilis L. ‘versicolor’ MAKINO in a continuing search for allergy-preventive substances from natural sources, using the in vivo assay method. This assay system uses monitoring of a decrease in the blood flow at the tail vein of mice subjected to hen egg-white lysozyme (HEL) sensitization. By bioassay-directed fractionation, a new flavonol triglycoside, quercetin 3-O-[β-D-xylopyranosyl(1→2)-α-L-rham...
#1Emiko Iwaoka (Hyogo University of Health Sciences)H-Index: 8
#2Hisae Oku (Mukogawa Women's University)H-Index: 16
Last.Kyoko Ishiguro (Mukogawa Women's University)H-Index: 24
view all 3 authors...
#1Hisae Oku (Mukogawa Women's University)H-Index: 16
#2Yuko Ogawa (Mukogawa Women's University)H-Index: 5
Last.Kyoko Ishiguro (Mukogawa Women's University)H-Index: 24
view all 4 authors...
SUMMARY 1 We discovered a phenomenon in which the blood flow of vein microcirculation markedly decreased in the pathology of metabolic syndrome using a model of SHR/NDmcr-cp/cp (SHR/cp) rats. We tried to develop an in vivo assay method to search for substances for primary prevention of the metabolic syndrome using this blood flow decrease as a guide. 2 Using the assay method, we examined various teas that were expected to prevent the metabolic syndrome when consumed daily. We also found that Kin...
#1Yuko OgawaH-Index: 5
#2Hisae OkuH-Index: 16
Last.Kyoko IshiguroH-Index: 24
view all 5 authors...
Allergy-preventive activity was demonstrated for an extract of the bark of Populus sieboldii in a continuing search for allergy-preventive substances from natural sources. By bioassay-directed fractionation of this plant bark, two new phenolic glycosides, siebolside A {2-hydroxy-5-[(benzoyloxy)methyl]phenyl (6‘-O-acetyl) β-d-glucopyranoside} (1) and siebolside B {2-hydroxy-5-[(benzoyloxy)methyl]phenyl β-d-glucopyranoside} (2), were isolated, together with three known compounds, salicin (3), saku...
#1Tohru Yamakuni (Tohoku University)H-Index: 17
#2Koichi Aoki (Tohoku University)H-Index: 2
Last.Yasushi Ohizumi (Tohoku University)H-Index: 46
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Abstract In the course of our survey of natural compounds inhibiting prostaglandin E 2 release and/or lipopolysaccharide (LPS)-induced transcriptional stimulation via NF-κB, a central regulator of inflammatory genes, from natural resources, we found garcinone B, a xanthone from callus tissue culture of Hypericum patulum , as a compound with such pharmacological activities, that is a derivative of γ-mangostin which potently inhibits COX-1 and COX-2 activities to reduce PGE 2 release from C6 rat g...
#1Hisae OkuH-Index: 16
#2Yoshimi UedaH-Index: 5
Last.Kyoko IshiguroH-Index: 24
view all 4 authors...
The inhibitory effects of 22 xanthones from three Guttiferae plants (Hypericum patulum, Calophyllum inophyllum and C. austroindium) on exogeneous platelet activating factor (PAF)-induced hypotension were examined using a blood pressure monitoring in vivo assay method. Guanandin (2), caloxanthone E (3), 1,3,5,6-tetrahydroxy-2-isoprenylxanthone (8), 6-deoxyjacareubin (11) and patulone (18) showed strong inhibition of PAF-induced hypotension, with inhibitory effects of more than 60%. Their ID 50 va...
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