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Julian Lange
Memorial Sloan Kettering Cancer Center
16Publications
12H-index
887Citations
Publications 16
Newest
Published on Dec 1, 2018in Nature Communications 12.35
Alexander Widger1
Estimated H-index: 1
(Francis Crick Institute),
Shantha K. Mahadevaiah28
Estimated H-index: 28
(Francis Crick Institute)
+ 13 AuthorsObah A. Ojarikre19
Estimated H-index: 19
(Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. However, the meiotic functions of the PIKK ATR have remained elusive, because germline-specific depletion of this kinase is challenging. Here we uncover roles for ATR in male mouse prophase I progression. ATR deletion causes chromosome...
4 Citations Source Cite
Published on Oct 18, 2017in Cell Cycle 3.30
Shintaro Yamada3
Estimated H-index: 3
(MSK: Memorial Sloan Kettering Cancer Center),
Seoyoung Kim3
Estimated H-index: 3
(MSK: Memorial Sloan Kettering Cancer Center)
+ 3 AuthorsScott Keeney47
Estimated H-index: 47
(MSK: Memorial Sloan Kettering Cancer Center)
ABSTRACTThe SPO11-generated DNA double-strand breaks (DSBs) that initiate meiotic recombination occur non-randomly across genomes, but mechanisms shaping their distribution and repair remain incompletely understood. Here, we expand on recent studies of nucleotide-resolution DSB maps in mouse spermatocytes. We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation of H3 lysine 4, consistent with coordinated...
19 Citations Source Cite
Published on Aug 30, 2017in PLOS Genetics 5.54
Devanshi Jain2
Estimated H-index: 2
(MSK: Memorial Sloan Kettering Cancer Center),
Cem Meydan11
Estimated H-index: 11
(Cornell University)
+ 4 AuthorsScott Keeney47
Estimated H-index: 47
(MSK: Memorial Sloan Kettering Cancer Center)
Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress transposable elements. It was previously thought that mammals possess four DNA methyltransferase paralogs—Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l—that establish and maintain cytosine-5 methylation. Here we identify a fifth paralog, Dnmt3c, that is essential for retrotransposon methylation and repression in the mouse male germline. From a phenotype-based forward genetics screen, we isolated a mutant mouse cal...
9 Citations Source Cite
Published on Nov 1, 2016in Nature Cell Biology 19.06
Marcello Stanzione4
Estimated H-index: 4
,
Marek Baumann4
Estimated H-index: 4
+ 10 AuthorsYoshinori Watanabe51
Estimated H-index: 51
In meiosis, double-strand breaks (DSBs) are induced to initiate chromosome pairing and synapsis. Stanzione et al. identify IHO1 as a protein recruited by HORMAD1 to unsynapsed chromosome axes and required for DSB formation.
29 Citations Source Cite
Published on Oct 1, 2016in Cell 31.40
Julian Lange12
Estimated H-index: 12
(MSK: Memorial Sloan Kettering Cancer Center),
Shintaro Yamada3
Estimated H-index: 3
(MSK: Memorial Sloan Kettering Cancer Center)
+ 6 AuthorsScott Keeney47
Estimated H-index: 47
(Cornell University)
Summary Heritability and genome stability are shaped by meiotic recombination, which is initiated via hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the genome is not random, but mechanisms molding this landscape remain poorly understood. Here, we exploit genome-wide maps of mouse DSBs at unprecedented nucleotide resolution to uncover previously invisible spatial features of recombination. At fine scale, we reveal a stereotyped hotspot structure—DSBs occur withi...
64 Citations Source Cite
Published on Mar 13, 2015in PLOS Genetics 5.54
Sarai Pacheco5
Estimated H-index: 5
(Autonomous University of Barcelona),
Marina Marcet-Ortega4
Estimated H-index: 4
(Autonomous University of Barcelona)
+ 3 AuthorsIgnasi Roig18
Estimated H-index: 18
(Autonomous University of Barcelona)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. Mechanisms underlying the recombination-dependent arrest response are not well understood, so we sought to identify factors...
30 Citations Source Cite
Published on Nov 23, 2014in Annual Review of Genetics 9.59
Scott Keeney47
Estimated H-index: 47
,
Julian Lange12
Estimated H-index: 12
,
Neeman Mohibullah4
Estimated H-index: 4
Recombination in meiosis is a fascinating case study for the coordination of chromosomal duplication, repair, and segregation with each other and with progression through a cell-division cycle. Meiotic recombination initiates with formation of developmentally programmed DNA double-strand breaks (DSBs) at many places across the genome. DSBs are important for successful meiosis but are also dangerous lesions that can mutate or kill, so cells ensure that DSBs are made only at the right times, place...
85 Citations Source Cite
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