Tian Tian
Memorial Hospital of South Bend
Molecular biologyNanoparticleMaterials scienceExosomeCell biology
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Publications 21
#1Song Fan (SYSU: Sun Yat-sen University)H-Index: 13
#2Tian Tian (Nanjing Medical University)H-Index: 11
Last. Jinsong Li (SYSU: Sun Yat-sen University)H-Index: 12
view all 31 authors...
Summary Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remains elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin sensitivity-associated lncRNA(CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 p...
1 CitationsSource
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. Interestingly, recent evidence shows plasticity between these subtypes in which the proneural (PN) glioma stem-like cells undergo transition into the more aggressive mesenchymal (MES) subtype leading to therapeutic resistance. Extracellula...
#1Tian Tian (Memorial Hospital of South Bend)H-Index: 11
#2Xiaobin Lv (NCU: Nanchang University)H-Index: 1
Last. Song Fan (Harvard University)H-Index: 13
view all 20 authors...
Purpose: The overall biological roles and clinical significance of most long noncoding RNAs (lncRNA) in chemosensitivity are not fully understood. We investigated the biological function, mechanism, and clinical significance of lncRNA NR_034085, which we termed miRNA processing–related lncRNA (MPRL), in tongue squamous cell carcinoma (TSCC). Experimental Design: LncRNA expression in TSCC cell lines with cisplatin treatment was measured by lncRNA microarray and confirmed in TSCC tissues. The func...
#1Gulsah Erel-AkbabaH-Index: 1
#2Litia A. Carvalho (Harvard University)H-Index: 5
Last. Bakhos A. Tannous (Harvard University)H-Index: 38
view all 10 authors...
Targeted therapy against the programmed cell death ligand-1 (PD-L1) blockade holds considerable promise for the treatment of different tumor types; however, little effect has been observed against gliomas thus far. Effective glioma therapy requires a delivery vehicle that can reach tumor cells in the central nervous system, with limited systemic side effect. In this study, we developed a cyclic peptide iRGD (CCRGDKGPDC)-conjugated solid lipid nanoparticle (SLN) to deliver small interfering RNAs ...
2 CitationsSource
#1Song Fan (Harvard University)H-Index: 13
#2Tian Tian (Nanjing Medical University)H-Index: 11
Last. Jinsong Li (SYSU: Sun Yat-sen University)H-Index: 12
view all 18 authors...
miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycol...
5 CitationsSource
#1Bakhos A. Tannous (Harvard University)H-Index: 38
#2Tian Tian (Harvard University)H-Index: 11
Last. Pierre J. Obeid (University of Balamand)H-Index: 8
view all 3 authors...
#1Gulsah Erel-Akbaba (Harvard University)H-Index: 1
#2Litia A. Carvalho (Harvard University)H-Index: 5
Last. Bakhos A. Tannous (Harvard University)H-Index: 38
view all 6 authors...
#1Tian Tian (Nanjing Medical University)H-Index: 11
#2Hui-Xin Zhang (Nanjing Medical University)H-Index: 2
Last. Jun Gao (Nanjing Medical University)H-Index: 2
view all 11 authors...
Abstract The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has ...
63 CitationsSource
#1Yanliang ZhuH-Index: 9
#2Gaofeng LiangH-Index: 12
Last. Zhongdang XiaoH-Index: 24
view all 6 authors...
In this study, a new type of amphiphilic cetylated polyethyleneimine (PEI) was synthesized, and then polylactic-co-glycolic acid (PLGA)/cetylated PEI/hyaluronic acid nanoparticles (PCPH NPs) were developed by self-assembly as a novel type of gene-delivering vehicle. The PCPH NPs showed good DNA-condensation ability by forming polyplexes with small particle size and positive zeta potential. The transfection efficiency and cytotoxicity of PCPH NPs were evaluated as plasmid DNA vectors to transfect...
13 CitationsSource
#1Tian Tian (SEU: Southeast University)H-Index: 11
#2Yanliang Zhu (SEU: Southeast University)H-Index: 9
Last. Zhongdang Xiao (SEU: Southeast University)H-Index: 24
view all 7 authors...
Abstract Exosomes are nanoscale membrane vesicles secreted from many types of cells. Carrying functional molecules, exosomes transfer information between cells and mediate many physiological and pathological processes. In this paper, utilizing selective inhibitors, molecular tools, and specific endocytosis markers, the cellular uptake of PC12 cell-derived exosomes was imaged by high-throughput microscopy and statistically analyzed. It was found that the uptake was through clathrin-mediated endoc...
157 CitationsSource