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Haibiao Guo
Southern Medical University
10Publications
8H-index
119Citations
Publications 10
Newest
#1Zhengqiang Zou (Southern Medical University)H-Index: 5
#2Jiajia Chen (Southern Medical University)H-Index: 3
Last.Jiangping Xu (Southern Medical University)H-Index: 11
view all 9 authors...
Overactivation of microglia contributes to the induction of neuroinflammation, which is highly involved in the pathology of many neurodegenerative diseases. Phosphodiesterase 4 (PDE4) represents a promising therapeutic target for anti-inflammation; however, the dose-limiting side effects, such as nausea and emesis, have impeded their clinic application. FCPR03, a novel selective PDE4 inhibitor synthesized in our laboratory, shows little or no emetic potency; however, the anti-inflammatory activi...
9 CitationsSource
#1Haibiao Guo (Southern Medical University)H-Index: 8
#2Yufang Cheng (Southern Medical University)H-Index: 11
Last.Jiangping Xu (Southern Medical University)H-Index: 11
view all 9 authors...
Abstract Thus far, phosphodiesterase-4 (PDE4) inhibitors have not been approved for application in Alzheimer's disease (AD) in a clinical setting due to severe side effects, such as nausea and vomiting. In this study, we investigated the effect of FFPM, a novel PDE4 inhibitor, on learning and memory abilities, as well as the underlying mechanism in the APP/PS1 mouse model of AD. Pharmacokinetic studies have revealed that FFPM efficiently permeates into the brain, and reached peak values in plasm...
22 CitationsSource
#1Yeye Zhuo (STU: Shantou University)H-Index: 1
#2Haibiao Guo (Southern Medical University)H-Index: 8
Last.Jiangping Xu (Southern Medical University)H-Index: 11
view all 10 authors...
Phosphodiesterase-4 (PDE4) inhibitors prevent the breakdown of the second messenger cAMP and have been demonstrated to improve learning in several animal models of cognition. In this study, we explored the antioxidative effects of rolipram in Alzheimer’s disease (AD) by using bilateral Aβ25–35 injection into the hippocampus of rats, which were used as an AD model. Rats received 3 intraperitoneal (i.p.) doses of rolipram (0.1, 0.5 and 1.25 mg/kg) daily after the injection of Aβ25–35 for 25 days. ...
10 CitationsSource
#1Xu LiuH-Index: 1
#2Haibiao GuoH-Index: 8
Last.Jiangping XuH-Index: 11
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GEBR-7b, a potential phosphodiesterase 4D inhibitor, has been shown to have memory-enhancing effects in rodents. However, it is still unknown whether GEBR-7b also has the antidepressant-like effects in rats. Herein, we examined the potential of GEBR-7b to attenuate depression-like behaviors in the rat model of depression induced by chronic unpredictable stress (CUS). Next, we also investigated the alterations of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA) catalytic subunit (PKA...
12 CitationsSource
#1Min Liu (Southern Medical University)H-Index: 1
#2Haibiao Guo (Southern Medical University)H-Index: 8
Last.Ren-an QinH-Index: 1
view all 8 authors...
Background Senile dementia mainly includes Alzheimer' s disease (AD) and vascular dementia (VD). AD is a progressive and irreversible neurodegenerative disorder that is accompanied with a great deal of social burden. The aim of this study was to investigate the effect of Compound Danshen (CDS) on learning and memory of alzheimer’s disease (AD) rat model, as well as to explore the possible connection between CDS and the associated molecules of amyloid beta (Aβ).
9 CitationsSource
#1Yiwen Li (Southern Medical University)H-Index: 2
#2Yufang Cheng (Southern Medical University)H-Index: 11
Last.Xue-Mei Yang (Southern Medical University)H-Index: 6
view all 9 authors...
Abstract In this study, we evaluated a simple and sensitive method for determination of a novel phosphodiesterase-4 (PDE4) inhibitor, chlorbipram, in mouse plasma and brain using ultra-fast liquid chromatography-tandem mass spectrometry (UFLC–MS/MS). Separation was achieved using an Acquity UPLC BEH C18 column (50 mm × 2.1 mm, particle size 1.7 μm) with a gradient mobile phase consisting of water and methanol at a flow rate of 0.25 ml/min. Detection was performed in the multiple reaction monitor...
Source
#1Haibiao Guo (Southern Medical University)H-Index: 8
#2Haitao Wang (Southern Medical University)H-Index: 6
Last.Jiangping Xu (Southern Medical University)H-Index: 11
view all 8 authors...
Amyloid plaques and neurofibrillary tangles are the key pathological features of Alzheimer’s disease (AD). Studies have shown that C-reactive protein (CRP) increases during inflammatory reactions and, therefore, has been associated with AD. However, there is no published report relating the impact of CRP to the regulation of tau phosphorylation. In the present study, we investigated the effects of CRP on the phosphorylation of tau protein in SH-SY5Y cells. Treatment of cells with CRP (5, 10, 20 ...
2 CitationsSource
#1Li Wan (Guangdong Pharmaceutical University)H-Index: 1
#2Yufang Cheng (Southern Medical University)H-Index: 11
Last.Jiao Guo (Guangdong Pharmaceutical University)H-Index: 3
view all 10 authors...
Abstract Ethnopharmacological relevance The Renshen Shouwu capsule (RSSW) is a patented Traditional Chinese Medicine (TCM), that has been proven to improve memory and is widely used in China to apoplexy syndrome and memory deficits. To investigate the neuroprotective and therapeutic effect of the Renshen Shouwu standardized extract (RSSW) on ischemic brain neuronal injury and impairment of learning and memory related to Vascular Dementia (VD) induced by a focal and global cerebral ischemia-reper...
13 CitationsSource
#1Haibiao Guo (Southern Medical University)H-Index: 8
#2Yufang Cheng (Southern Medical University)H-Index: 11
Last.Jiang-Ping Xu (Southern Medical University)H-Index: 12
view all 8 authors...
Abstract Donepezil, a cholinesterase inhibitor, is a representative symptomatic therapy for Alzheimer’s disease (AD). Recent studies have reported the anti-inflammatory effects of donepezil. However, limited studies that investigate its anti-inflammatory effect in AD have been reported. Considering the role of proinflammatory molecules and microglial activation in the pathogenesis of AD, the current study aimed to elucidate the effects of donepezil on microglial activation induced by amyloid dep...
31 CitationsSource
#1Bao-Fang Liang (Southern Medical University)H-Index: 2
#2Fang Huang (Southern Medical University)H-Index: 1
Last.Jiangping Xu (Southern Medical University)H-Index: 11
view all 9 authors...
AbstractContext: Previous studies from our laboratory indicated that both acute and subchronic administration of Fructus Akebiae (FAE) [the fruit of Akebiae quinata (Thunb.) Decne, (Lardizabalaceae)] produce antidepressant-like effects in animal depressive behavior tests. FAE contains approximately 70% of hederagenin (HG) as its main chemical component.Objective: This study compared the antidepressant ability of FAE with that of HG in mice and further investigated the antidepressant-like effects...
11 CitationsSource
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