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Alf Giese
University of Mainz
103Publications
26H-index
2,089Citations
Publications 103
Newest
#1Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Alexey Moiseev (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 1
view all 14 authors...
Abstract Molecular diagnostics is becoming one of the major drivers of personalized oncology. With hundreds of different approved anticancer drugs and regimens of their administration, selecting the proper treatment for a patient is at least nontrivial task. This is especially sound for the cases of recurrent and metastatic cancers where the standard lines of therapy failed. Recent trials demonstrated that mutation assays have a strong limitation in personalized selection of therapeutics, conseq...
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#1Ella L. Kim (University of Mainz)H-Index: 7
#2Anton BuzdinH-Index: 26
Last.Alf GieseH-Index: 26
view all 10 authors...
e13533Background: This study developed molecular guided tools for individualized selection of chemotherapeutics for recurrent glioblastoma (rGB). A consortium involving clinical neurooncologists, m...
1 CitationsSource
#1Elena PoddubskayaH-Index: 6
#2Anton BuzdinH-Index: 26
Last.Nikolay M. Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 14
view all 17 authors...
e13143Background: Anticancer Targeted Drugs (ATDs) specifically target one or a few types of tumor-related molecules in a cell. More than two hundred of ATDs were approved worldwide. They have diff...
1 CitationsSource
#2Alf GieseH-Index: 26
The authors present their technique and pitfalls with cervical percutaneous pedicle screw fixation. Special care has to be given to tubular screw tract preparation, surgical planning, and insertion of percutaneous screw in the cervical spine. Experience with open cervical pedicle screw placement is important before considering to perform percutaneous technique in very selected patients.
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#1Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Nicolas Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 8
view all 13 authors...
Abstract Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play important roles in cancer development and progression, being deeply implicated in intracellular signaling pathways. To date, hundreds of different ATDs were approved for clinical use in the different countries. Compared to previous chemotherapy treatments, ATDs often demonstrate reduced side effects and increased efficiency, but also have higher costs. However, the efficiency of ATDs for the advance...
16 CitationsSource
#1Nevenka Dudvarski Stankovic (DKFZ: German Cancer Research Center)H-Index: 4
#2Frank Bicker (DKFZ: German Cancer Research Center)H-Index: 7
Last.Mirko H. H. Schmidt (DKFZ: German Cancer Research Center)H-Index: 29
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Abstract Glioblastoma (GBM) is a typically lethal type of brain tumor with a median survival of 15 months postdiagnosis. This negative prognosis prompted the exploration of alternative treatment options. In particular, the reliance of GBM on angiogenesis triggered the development of anti‐VEGF (vascular endothelial growth factor) blocking antibodies such as bevacizumab. Although its application in human GBM only increased progression‐free periods but did not improve overall survival, physicians a...
4 CitationsSource
#2Philipp WinterH-Index: 1
Last.Naureen KericH-Index: 6
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#1Julia Masomi-Bornwassser (University of Mainz)H-Index: 1
#2Fabio Freguia (University of Mainz)H-Index: 1
Last.Naureen Keric (University of Mainz)H-Index: 6
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Objective Although fibrinolytic therapy is an upcoming treatment for intracerebral haemorrhage (ICH), standard guidelines are lacking, and some clinical issues persist. Here, we used our recently devised clot model of ICH to systematically analyse effects of irrigation and cerebrospinal fluid (CSF) on fibrinolysis.
1 CitationsSource
#2Melanie LiemH-Index: 1
Last.Alf GieseH-Index: 26
view all 4 authors...
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#2Melanie LiemH-Index: 1
Last.Alf GieseH-Index: 26
view all 5 authors...
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