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Hideto Ishii
Tokyo Medical and Dental University
32Publications
13H-index
767Citations
Publications 32
Newest
#1Yuka Kamijo (Tokyo Medical and Dental University)H-Index: 1
#2Hideto Ishii (Tokyo Medical and Dental University)H-Index: 13
Last.Masayuki Yoshida (Tokyo Medical and Dental University)H-Index: 39
view all 9 authors...
Introduction:Recently, the sodium-glucose cotransporter2 (SGLT2) inhibitor empagliflozin has been shown to lower cardiovascular risk among diabetic patients. It is intriguing that some SGLT2 inhibi...
#1Shunsuke Ito (Tokyo Medical and Dental University)H-Index: 5
#2Yusuke HiguchiH-Index: 6
Last.Masayuki Yoshida (Tokyo Medical and Dental University)H-Index: 39
view all 8 authors...
Accelerated cardiovascular disease is a frequent complication of CKD. Monocyte-mediated inflammation and adhesion of monocytes to vascular endothelium are key events in atherogenesis. An oral adsorbent, AST120, retards renal function deterioration by lowering IS, which is known to accumulate in CKD patients. However, the effect of AST-120 on CKD-related monocyte activation is unknown. We aimed to determine whether AST-120 improves monocyte-mediated inflammation through IS reduction. Flow cytomet...
#1Hideto Ishii (UNSW: University of New South Wales)H-Index: 13
#2Mark D. Hulett (La Trobe University)H-Index: 35
Last.Levon M. Khachigian (UNSW: University of New South Wales)H-Index: 54
view all 6 authors...
#1Mariko Tani (Ochanomizu University)H-Index: 12
#2Akio Kawakami (Tokyo Medical and Dental University)H-Index: 17
Last.Masayuki Yoshida (Tokyo Medical and Dental University)H-Index: 39
view all 8 authors...
Aim: Increased levels of small dense low-density lipoproteins (sd-LDL) have been reported more atherogenic compared to total low-density lipoprotein (LDL); however, no definitive experiments using macrophages have examined this concept in vitro.Method and Result: In this study, we isolated fractions of total LDL (density 1.019-1.063g/ml) and sd-LDL (density 1.044-1.063g/ml) from the plasma of subjects with modest hypertriglycidemia. Oxidizabilty as assessed by copper-induced generation (1.6 µmol...
#1Shunsuke ItoH-Index: 5
#2Mizuko OsakaH-Index: 11
Last.Masayuki YoshidaH-Index: 39
view all 6 authors...
Despite a positive correlation between chronic kidney disease and atherosclerosis, the causative role of uremic toxins in leukocyte-endothelial interactions has not been reported. We thus examined the effects of indoxyl sulfate, a uremic toxin, on leukocyte adhesion to activated endothelial cells and the underlying mechanisms. Pretreatment of human umbilical vein endothelial cells (HUVEC) with indoxyl sulfate significantly enhanced the adhesion of human monocytic cells (THP-1 cell line) to TNF-α...
#1Chiari Kojima (Tokyo Medical and Dental University)H-Index: 11
#2Jun Ino (Tokyo Medical and Dental University)H-Index: 4
Last.Masayuki Yoshida (Tokyo Medical and Dental University)H-Index: 39
view all 5 authors...
Aim: Angiotensin-converting enzyme inhibitors (ACEIs) have been shown to block matrix metalloproteinase (MMP)-9 activity, which plays a role in atherogenesis. MMP-9 activity of macrophages is increased during foam cell formation. To investigate the contribution of ACEIs to foam cell formation, we studied the effects of an ACEI, imidaprilat, on THP-1 macrophages and the underlying molecular mechanisms in vitro.Methods and Results: Pre-treatment of THP-1 macrophages with imidaprilat (100 nmol/L, 4...
The present study attempted to define the role of hepatic Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter, in hepatic insulin resistance as well as hepatic steatosis. The inhibition of NPC1L1 and its molecular consequences were examined in Zucker obese fatty (ZOF) rats and cultured steatotic hepatocytes using ezetimibe, a pharmacoloigcal inhibitor of NPC1L1, and short hairpin RNA (shRNA) of NPC1L1. Ezetimibe improved hepatic insulin signaling as well as hepatic steatosis in ZOF rats. ...
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