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Giulio Cossu
University of Milan
332Publications
69H-index
20.9kCitations
Publications 332
Newest
Published on May 1, 2019in Journal of Cellular Physiology 3.92
Luca Ferrari32
Estimated H-index: 32
(University of Milan),
Cinzia Bragato7
Estimated H-index: 7
(University of Milano-Bicocca)
+ 14 AuthorsAntonio Giordano75
Estimated H-index: 75
(University of Siena)
1 Citations Source Cite
Published on Mar 1, 2019in Regenerative Medicine 2.99
Glyn Stacey6
Estimated H-index: 6
(University of Hertfordshire),
Peter W. Andrews60
Estimated H-index: 60
(University of Sheffield)
+ 17 AuthorsZoe Hewitt2
Estimated H-index: 2
(University of Sheffield)
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture of what can be very complex products, is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, ...
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Published on Mar 1, 2019in Stem cell reports 6.54
Mattia F M Gerli6
Estimated H-index: 6
(University College London),
Louise A. Moyle6
Estimated H-index: 6
(University College London)
+ 11 AuthorsP. Ala2
Estimated H-index: 2
(University College London)
Summary Satellite cells are responsible for skeletal muscle regeneration. Upon activation, they proliferate as transient amplifying myoblasts, most of which fuse into regenerating myofibers. Despite their remarkable differentiation potential, these cells have limited migration capacity, which curtails clinical use for widespread forms of muscular dystrophy. Conversely, skeletal muscle perivascular cells have less myogenic potential but better migration capacity than satellite cells. Here we show...
1 Citations Source Cite
Published on Jan 1, 2019in Molecular Therapy 7.01
Irene de Lázaro6
Estimated H-index: 6
(University of Manchester),
Açelya Yilmazer9
Estimated H-index: 9
(University of Manchester)
+ 5 AuthorsKostas Kostarelos63
Estimated H-index: 63
(University of Manchester)
Overexpression of Oct3/4 , Klf4 , Sox2 , and c-Myc (OKSM) transcription factors can de-differentiate adult cells in vivo . While sustained OKSM expression triggers tumorigenesis through uncontrolled proliferation of toti- and pluripotent cells, transient reprogramming induces pluripotency-like features and proliferation only temporarily, without teratomas. We sought to transiently reprogram cells within mouse skeletal muscle with a localized injection of plasmid DNA encoding OKSM (pOKSM), and we...
1 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Bashar Aldeiri2
Estimated H-index: 2
(Boston Children's Hospital),
Urmas Roostalu11
Estimated H-index: 11
(Manchester Academic Health Science Centre)
+ 4 AuthorsGiulio Cossu69
Estimated H-index: 69
(Manchester Academic Health Science Centre)
Pentalogy of Cantrell (PC) is a rare multi-organ congenital anomaly that impedes ventral body wall closure and results in diaphragmatic hernia, intra- and pericardial defects. The underlying cellular and molecular changes that lead to these severe developmental defects have remained unknown largely due to the lack of representative animal models. Here we provide in depth characterization of a mouse model with conditional ablation of TGFβRII in Transgelin (Tagln) expressing cells. We show that Ta...
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Luca Urbani14
Estimated H-index: 14
(University College London),
C Camilli2
Estimated H-index: 2
(University College London)
+ 28 AuthorsAnna Urciuolo3
Estimated H-index: 3
(University College London)
A tissue engineered oesophagus could overcome limitations associated with oesophageal substitution. Combining decellularized scaffolds with patient-derived cells shows promise for regeneration of tissue defects. In this proof-of-principle study, a two-stage approach for generation of a bio-artificial oesophageal graft addresses some major challenges in organ engineering, namely: (i) development of multi-strata tubular structures, (ii) appropriate re-population/maturation of constructs before tra...
3 Citations Source Cite
Published on Nov 1, 2018in Human Molecular Genetics 4.90
Ewa J. Mularczyk3
Estimated H-index: 3
(University of Manchester),
Mukti Singh3
Estimated H-index: 3
(University of Manchester)
+ 10 AuthorsRay Boot-Handford40
Estimated H-index: 40
(University of Manchester)
3 Citations Source Cite
Published on Apr 5, 2018in Frontiers in Physiology 3.39
Eyemen Kheir (University of Trento), Gabriella Cusella4
Estimated H-index: 4
(University of Pavia)
+ 2 AuthorsStefano Biressi14
Estimated H-index: 14
(University of Trento)
The formation and activity of mammalian tissues entail finely regulated processes, involving the concerted organization and interaction of multiple cell types. In recent years the prospective isolation of distinct progenitor and stem cell populations has become a powerful tool in the hands of developmental biologists and has rendered the investigation of their intrinsic properties possible. In this protocol, we describe how to purify progenitors with different lineage history and degree of diffe...
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Published on Jan 1, 2018in Cell Death and Disease 5.64
Cesare Gargioli17
Estimated H-index: 17
(University of Rome Tor Vergata),
Giuseppina Turturici9
Estimated H-index: 9
(University of Palermo)
+ 8 AuthorsGabriella Sconzo18
Estimated H-index: 18
(University of Palermo)
Cell engraftment, survival and integration during transplantation procedures represent the crux of cell-based therapies. Thus, there have been many studies focused on improving cell viability upon implantation. We used severe oxidative stress to select for a mouse mesoangioblast subpopulation in vitro and found that this subpopulation retained self-renewal and myogenic differentiation capacities while notably enhancing cell survival, proliferation and migration relative to unselected cells. Addi...
10 Citations Source Cite
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