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Giulio Cossu
University of Milan
332Publications
69H-index
20.9kCitations
Publications 332
Newest
#1T. Kisby (University of Manchester)
#2I. de Lazaro (Harvard University)
Last.Kostas Kostarelos (University of Manchester)H-Index: 63
view all 0 authors...
Zebrafish and urodele amphibians are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through transient expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) transcription factors. Here, we utilized an OSKM-encoding non-integrating vector to induce transient reprogramming of mammalian cardiomyocytes in vitro. ...
#1Benedetta Arnò (University of Manchester)
#2Francesco Galli (University of Manchester)
Last.Elizabeth J. Cartwright (MAHSC: Manchester Academic Health Science Centre)H-Index: 27
view all 11 authors...
Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor beta (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programs via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-phosphorylation of SMAD2/3 have remained poorly characterized. Here we show that tissu...
#1Michele De Luca (University of Modena and Reggio Emilia)H-Index: 36
#2Alessandro Aiuti (UniSR: Vita-Salute San Raffaele University)H-Index: 48
Last.Pamela Gehron Robey (NIH: National Institutes of Health)H-Index: 81
view all 6 authors...
Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental approaches, caveats and results underpinning the clinical use of such stem cells.
#1Giulio Cossu (University of Manchester)H-Index: 69
#2Francesco Galli (University of Manchester)
Last.Elizabeth J. Cartwright (University of Manchester)H-Index: 27
view all 10 authors...
Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor beta (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programs via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-phosphorylation of SMAD2/3 have remained poorly characterized. Here we show that tissu...
#1Luca Ferrari (University of Milan)H-Index: 32
#2Cinzia Bragato (University of Milano-Bicocca)H-Index: 7
Last.Antonio Giordano (UNISI: University of Siena)H-Index: 75
view all 17 authors...
#1Glyn StaceyH-Index: 24
#2Glyn Stacey (University of Hertfordshire)H-Index: 6
Last.Jason Halliwell (University of Sheffield)H-Index: 1
view all 20 authors...
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, biomanufacturing and regulation, to di...
#1Mattia F M Gerli (UCL: University College London)H-Index: 6
#2Mattia Francesco Maria Gerli (UCL: University College London)
Last.Hiroshi Sakai (Pasteur Institute)H-Index: 4
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Summary Satellite cells are responsible for skeletal muscle regeneration. Upon activation, they proliferate as transient amplifying myoblasts, most of which fuse into regenerating myofibers. Despite their remarkable differentiation potential, these cells have limited migration capacity, which curtails clinical use for widespread forms of muscular dystrophy. Conversely, skeletal muscle perivascular cells have less myogenic potential but better migration capacity than satellite cells. Here we show...
#1Irene de Lázaro (University of Manchester)H-Index: 6
#2Açelya Yilmazer (University of Manchester)H-Index: 9
Last.Kostas Kostarelos (University of Manchester)H-Index: 63
view all 8 authors...
Overexpression of Oct3/4 , Klf4 , Sox2 , and c-Myc (OKSM) transcription factors can de-differentiate adult cells in vivo . While sustained OKSM expression triggers tumorigenesis through uncontrolled proliferation of toti- and pluripotent cells, transient reprogramming induces pluripotency-like features and proliferation only temporarily, without teratomas. We sought to transiently reprogram cells within mouse skeletal muscle with a localized injection of plasmid DNA encoding OKSM (pOKSM), and we...
#1Bashar Aldeiri (Boston Children's Hospital)H-Index: 2
#2Urmas Roostalu (MAHSC: Manchester Academic Health Science Centre)H-Index: 11
Last.Giulio Cossu (MAHSC: Manchester Academic Health Science Centre)H-Index: 69
view all 7 authors...
Pentalogy of Cantrell (PC) is a rare multi-organ congenital anomaly that impedes ventral body wall closure and results in diaphragmatic hernia, intra- and pericardial defects. The underlying cellular and molecular changes that lead to these severe developmental defects have remained unknown largely due to the lack of representative animal models. Here we provide in depth characterization of a mouse model with conditional ablation of TGFβRII in Transgelin (Tagln) expressing cells. We show that Ta...
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