Simon Akerman
New York University
What is this?
Publications 72
#1Jan HoffmannH-Index: 14
#2Silke Miller (Amgen)H-Index: 8
Last. Sonya G. Lehto (Amgen)H-Index: 14
view all 15 authors...
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclinical evidence suggests that PACAP38 modulates trigeminal nociceptive activity mainly through PAC1 receptors while clinical studies report that plasma concentrations of PACAP38 are elevated in spontaneous attacks of cluster headache and migraine and normalize after treatment with sumatriptan. Intravenous infusion of PACAP38 induces migraine-like attacks in migraineurs and cluste...
#1Simon Akerman (UMB: University of Maryland, Baltimore)H-Index: 29
#2Marcela Romero-Reyes (UMB: University of Maryland, Baltimore)H-Index: 10
The use of neuromodulatory devices for the treatment of neurological disorders provides a non-invasive and non-pharmacologic therapeutic approach for patients. Recent years have seen a significant increase in the development and assessment of the efficacy of these devices to treat primary headache and facial pain disorders. Non-invasive stimulation of the cervical vagus nerve afferent projection is one such approach whose development is very much advanced, having undergone several clinical trial...
#1Simon Akerman (UMB: University of Maryland, Baltimore)H-Index: 3
#2Cristina TassorelliH-Index: 38
Trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders characterised by severe unilateral head pain, coupled with significant lateralised cranial autonomic features. They significantly impair patients’ quality of life, which is also hindered by limited treatment options. Our understanding of these disorders and the development of novel and more effective treatments has been limited by the lack of reliable animal models to explore the pathophysiological mechanism...
#1Marta Vila-Pueyo ('KCL': King's College London)H-Index: 8
#2Jan Hoffmann (UHH: University of Hamburg)H-Index: 14
Last. Simon Akerman (UMB: University of Maryland, Baltimore)H-Index: 3
view all 4 authors...
ObjectiveTo review and discuss the literature relevant to the role of brainstem structure and function in headache.BackgroundPrimary headache disorders, such as migraine and cluster headache, are c...
3 CitationsSource
#1Yadong Ji (UMB: University of Maryland, Baltimore)H-Index: 7
#2Alexandra M. Rizk (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Radi Masri (UMB: University of Maryland, Baltimore)H-Index: 18
view all 8 authors...
Abstract Background and purpose Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology. CGRP acts primarily by activating a receptor composed of 3 proteins: calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP). We tested the hypothesis that sex differences exist in protein levels of two key components of this CGRP receptor: CLR and RCP. Methods We used specific antibodies to assess baselin...
1 CitationsSource
#1Simon Akerman (NYU: New York University)H-Index: 29
#2Nazia Karsan (University of Cambridge)H-Index: 6
Last. Peter J. Goadsby (University of Cambridge)H-Index: 111
view all 7 authors...
6 CitationsSource
#1Yonglie Zhao (UCSF: University of California, San Francisco)H-Index: 1
#2Margarida Martins-Oliveira ('KCL': King's College London)H-Index: 3
Last. Peter J. Goadsby (UCSF: University of California, San Francisco)H-Index: 111
view all 4 authors...
BackgroundMigraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment. There is a need to identify novel targets and test their potential efficacy in relevant preclinical migraine models. Traditional Chinese medicines have been used for millennia and may offer avenues for exploration.MethodsWe evaluated two traditional Chinese medicines, gastrodin and ligustrazine, and compared them to two Western approaches with prop...
4 CitationsSource
#1James A. Waschek (Semel Institute for Neuroscience and Human Behavior)H-Index: 38
#2Serapio M. Baca (Anschutz Medical Campus)H-Index: 12
Last. Simon Akerman (NYU: New York University)H-Index: 29
view all 3 authors...
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in headache research. In addition to suggesting potential therapeutic targets for migraine, the finding provides an opportunity to better understand the pathological events from early events (aura) to the headache itself. Although PACAP-38 and the close...
7 CitationsSource
#1Amynah A. Pradhan (UIC: University of Illinois at Chicago)H-Index: 11
#2Zachariah Bertels (UIC: University of Illinois at Chicago)H-Index: 2
Last. Simon Akerman (UMB: University of Maryland, Baltimore)H-Index: 3
view all 3 authors...
Nitric oxide (NO) is a small gaseous signaling molecule that has important biological effects. It has been heavily implicated in migraine; and the NO donor, nitroglycerin, has been used extensively as a human migraine trigger. Correspondingly, a number of components of the NO signaling cascade have been shown to be upregulated in migraine patients. NO is endogenously produced in the body by NO synthase (NOS), of which there are three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and ind...
13 CitationsSource
#1Jan Hoffmann (UHH: University of Hamburg)H-Index: 14
#2Serapio M. Baca (UM: University of Montana)H-Index: 12
Last. Simon Akerman (UMB: University of Maryland, Baltimore)H-Index: 3
view all 3 authors...
Vascular theories of migraine and cluster headache have dominated for many years the pathobiological concept of these disorders. This view is supported by observations that trigeminal activation induces a vascular response and that several vasodilating molecules trigger acute attacks of migraine and cluster headache in susceptible individuals. Over the past 30 years, this rationale has been questioned as it became clear that the actions of some of these molecules, in particular, calcitonin gene-...
6 CitationsSource