Jingyu Liu
Georgia Institute of Technology
Single-nucleotide polymorphismPsychologyNeuroscienceIndependent component analysisSchizophrenia
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Publications 131
Objective: Multimodal measurements of the same phenomena provide complementary information and highlight different perspectives, albeit each with their own limitations. A focus on a single modality may lead to incorrect inferences, which is especially important when a studied phenomenon is a disease. In this paper, we introduce a method that takes advantage of multimodal data in addressing the hypotheses of disconnectivity and dysfunction within schizophrenia (SZ). Methods: We start with estimat...
#1Tianye Jia (Fudan University)H-Index: 14
#2Congying Chu ('KCL': King's College London)H-Index: 2
Last. Sylvane Desrivières ('KCL': King's College London)H-Index: 25
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DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
2 CitationsSource
#1Jiayu ChenH-Index: 16
#2Gunter SchumannH-Index: 51
Last. Jingyu LiuH-Index: 30
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#1Dongdong Lin (The Mind Research Network)H-Index: 13
#2Kent E. Hutchison (CU: University of Colorado Boulder)H-Index: 48
Last. Vince D. Calhoun (UNM: University of New Mexico)H-Index: 93
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Abstract Recent studies have shown a critical role of the gastrointestinal microbiome in brain and behavior via the complex gut–microbiome–brain axis. However, the influence of the oral microbiome in neurological processes is much less studied, especially in response to the stimuli, such as smoking, within the oral microenvironment. Additionally, given the complex structural and functional networks in brain, our knowledge about the relationship between microbiome and brain function through speci...
#1Kuaikuai DuanH-Index: 1
#2Jiayu ChenH-Index: 16
Last. Jingyu LiuH-Index: 30
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#1Faith M. Hanlon (The Mind Research Network)H-Index: 25
#2Ronald A. Yeo (UNM: University of New Mexico)H-Index: 46
Last. Andrew R. MayerH-Index: 43
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Abstract Background Patients with psychotic spectrum disorders share overlapping clinical/biological features, making it often difficult to separate them into a discrete nosology (i.e., Diagnostic and Statistical Manual of Mental Disorders [DSM]). Methods The current study investigated whether a continuum classification scheme based on symptom burden would improve conceptualizations for cognitive and real-world dysfunction relative to traditional DSM nosology. Two independent samples (New Mexico...
#1Eva Mennigen (UCLA: University of California, Los Angeles)H-Index: 3
#2Wenhao Jiang (GSU: Georgia State University)H-Index: 1
Last. Jessica A. Turner (GSU: Georgia State University)H-Index: 53
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Abstract Schizophrenia is a complex disorder that affects perception, cognition, and emotion causing symptoms such as delusions, hallucinations, and suspiciousness. Schizophrenia is also associated with structural cortical abnormalities including lower gray matter (GM) concentration, GM volume, and cortical thickness relative to healthy control individuals. However, the association between GM measures and symptom dimensions in schizophrenia is still not well understood. Here, we applied parallel...
1 CitationsSource
#1Jason P. WeickH-Index: 14
#2Amber ZimmermanH-Index: 1
Last. Nikolaos MelliosH-Index: 11
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#1Jiayu Chen (The Mind Research Network)H-Index: 16
#2Jingyu Liu (The Mind Research Network)H-Index: 30
Last. Vince D. Calhoun (The Mind Research Network)H-Index: 93
view all 3 authors...
Imaging genomics focuses on characterizing genomic influence on the variation of neurobiological traits, holding promise for illuminating the pathogenesis, reforming the diagnostic system, and precision medicine of mental disorders. This paper aims to provide an overall picture of the current status of neuroimaging-genomic analyses in mental disorders, and how we can increase their translational potential into clinical practice. The review is organized around three perspectives: 1) toward reliab...