Deeb Daoud
Rambam Health Care Campus
EndocrinologyProgenitor cellEndothelial progenitor cellNitric oxideMedicine
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Publications 3
#1Irit Hochberg (Rambam Health Care Campus)H-Index: 6
#2Deeb Daoud (Rambam Health Care Campus)H-Index: 2
Last. Elad Yom-Tov (Microsoft)H-Index: 22
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Aims Diabetes is often diagnosed late. This study aimed to assess the possibility for earlier detection of diabetes from search data, using predictive models trained on large-scale data.
1 CitationsSource
#1Saher Hamed (Rappaport Faculty of Medicine)H-Index: 1
#2Barry M. Brenner (Rappaport Faculty of Medicine)H-Index: 123
Last. Ariel Roguin (Rappaport Faculty of Medicine)H-Index: 3
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Abstract Introduction Type 2 diabetes mellitus (DM) patients with coronary artery disease (CAD) have elevated plasma oxidized-LDL (OxLDL) levels and impaired neovascularization. Hyperglycemia and hyperlipidemia impair endothelial progenitor cell (EPC) migration, and endothelial nitric oxide (NO) bioavailability and NO synthase (NOS) activity are essential for EPC migration. Stromal-derived factor-1α (SDF1α) contributes to EPC mobilization and homing by stimulating the CXC receptor-4 (CXCR4) on t...
52 CitationsSource
#1Saher Hamed (Technion – Israel Institute of Technology)H-Index: 7
#2Barry M. Brenner (Technion – Israel Institute of Technology)H-Index: 123
Last. Ariel Roguin (Technion – Israel Institute of Technology)H-Index: 34
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Background: The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tolerate oxidative stress by upregulating superoxide dismutase (SOD), the enzyme that neutralizes superoxide anion (O 2 -). Therefore, we investigated the roles of NO and SOD in glucose-stressed EPCs. Methods: The functions of circulating EPCs from patients with type 2 diabetes wer...
69 CitationsSource