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Zhenyao Luo
University of Queensland
10Publications
3H-index
74Citations
Publications 10
Newest
#1Zhenyao LuoH-Index: 3
#2Rebecca CampbellH-Index: 1
Last.Christopher A. McDevittH-Index: 22
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#1Zhenyao Luo (UQ: University of Queensland)H-Index: 3
#2Victoria G. Pederick (University of Adelaide)H-Index: 4
Last.Bostjan Kobe (UQ: University of Queensland)H-Index: 52
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The bacterium Streptococcus pneumoniae (the pneumococcus) is a major human pathogen that requires Zn for its survival and virulence in the host environment. Polyhistidine triad protein D (PhtD) has a known role in pneumococcal Zn homeostasis. However, the mechanistic basis of PhtD function remains unclear, partly due to a lack of structural information. Here, we determined the crystal structure of the fragment PhtD , containing the third Zn -binding histidine triad (HT) motif of the protein. Ana...
2 CitationsSource
#1Zhenyao LuoH-Index: 3
Last.Bostjan KobeH-Index: 52
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#1Timothy M. Ryan (Australian Synchrotron)H-Index: 17
#2Jill Trewhella (USYD: University of Sydney)H-Index: 42
Last.Nigel Kirby (Australian Synchrotron)H-Index: 28
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A new optimized size exclusion chromatography small-angle X-ray scattering (SEC-SAXS) system for biomolecular SAXS at the Australian Synchrotron SAXS/WAXS beamline has been developed. The compact configuration reduces sample dilution to maximize sensitivity. Coflow sample presentation allows an 11-fold increase in flux on sample without capillary fouling, improving throughput and data quality, which are now primarily limited by the full flux available on the beamline. Multi-wavelength fibre opti...
10 CitationsSource
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#1Zhenyao Luo (UQ: University of Queensland)H-Index: 3
#2Jacqueline R. Morey (University of Adelaide)H-Index: 5
Last.Bostjan Kobe (UQ: University of Queensland)H-Index: 52
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Zn2+ is an essential nutrient for all known forms of life. In the major human pathogen Streptococcus pneumoniae, the acquisition of Zn2+ is facilitated by two Zn2+-specific solute-binding proteins: AdcA and AdcAII. To date, there has been a paucity of structural information on AdcA, which has hindered a deeper understanding of the mechanism underlying pneumococcal Zn2+ acquisition. Native AdcA consists of two domains: an N-terminal ZnuA domain and a C-terminal ZinT domain. In this study, the Znu...
2 CitationsSource
#1Megha BajajH-Index: 3
Last.Mark E. CooperH-Index: 128
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Streptococcus pneumoniae is a leading cause of life-threatening bacterial infections, especially in young children in developing countries. Pneumococcal infections can be treated with β-lactam antibiotics, but rapid emergence of multidrug-resistant strains of S. pneumoniae over the past two decades has emphasized the need to identify novel drug targets. Pneumococcal surface antigen A (PsaA) is one such target, found on the cell surface of S. pneumoniae. It functions as a high-affinity substrate-...
10 CitationsSource
#1Stephanie L. Begg (University of Adelaide)H-Index: 6
#2Bart A. Eijkelkamp (University of Adelaide)H-Index: 16
Last.Christopher A. McDevitt (University of Adelaide)H-Index: 22
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The molecular basis for the high toxicity of cadmium is unclear. Here, Begg et al. use the bacterium Streptococcus pneumoniae as a model system, and show that cadmium uptake increases sensitivity to oxidative stress by reducing intracellular concentrations of manganese and zinc through different mechanisms.
50 CitationsSource
#1Zhenyao LuoH-Index: 3
#2Rafael M. CouñagoH-Index: 13
Last.Bostjan KobeH-Index: 52
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