Yongfeng Yang
Xinxiang Medical University
Single-nucleotide polymorphismPsychologyPopulationGeneticsSchizophrenia
What is this?
Publications 45
#1Ruize Song (SEU: Southeast University)H-Index: 1
#2Ying Bai (SEU: Southeast University)H-Index: 11
Last. Yongfeng Yang (Xinxiang Medical University)H-Index: 12
view all 11 authors...
Abstract Background Reduced plasma circular RNA DYM (circDYM) has been detected in patients with major depressive disorder (MDD). Mechanism research has demonstrated that circDYM, acting as a microRNA-9 sponge, suppressed microglial activation by increasing Heat Shock Protein 90 ubiquitination, indicating that circDYM could be a potential biomarker of MDD. Methods Thirty-two normal controls (NCs) and 60 MDD patients were recruited. Enrolled patients were randomly allocated to the real or sham re...
#1Zhijun Zhang (SEU: Southeast University)H-Index: 42
#2Hongxing Zhang (Xinxiang Medical University)H-Index: 13
Last. Bi Wang (Xinxiang Medical University)H-Index: 1
view all 16 authors...
To determine whether repetitive transcranial magnetic stimulation (rTMS) of the visual cortex (VC) provides effective and well-tolerated treatment and whether magnetic resonance imaging (MRI) measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder (MDD), we performed a sham-controlled, double-blind, randomized, three-arm VC rTMS treatment study in 74 MDD patients. Neuronavigated rTMS (10 Hz, 90% of resting motor threshold, 1,600 pulses over 20 min t...
#1Liu SH-Index: 1
#1Shu Liu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Liu BH-Index: 1
view all 26 authors...
Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated. Aims To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functi...
5 CitationsSource
#2Yongfeng YangH-Index: 12
Last. Xueqin Song (Zhengzhou University)H-Index: 12
view all 10 authors...
Objectives: Abnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting the sACC as a potentially effective target for therapeutic modulation in cases resistant to conventional treatments (treatment-resistant depression, TRD). We hypothesized that areas in the prefrontal cortex (PFC) with direct fiber connections to the sACC may be particularly effective sites for treatment using transcranial magnetic stimulation (TMS). The aim of this study was to...
#1Wenqiang Li (Xinxiang Medical University)H-Index: 13
#2Fuping Sun (Xinxiang Medical University)
Last. Luxian Lv (Xinxiang Medical University)H-Index: 20
view all 15 authors...
Abstract Extracellular signal-regulated kinase (ERK) signal transduction is known to be associated with neurogenesis and neuronal differentiation and as such may be related to the synaptic plasticity associated with cognitive function. Although antipsychotic drug studies have suggested a potential role for the ERK cascade in schizophrenia, the mechanistic basis is unknown. The maternal immune activation (MIA) rat model is a well-known to simulate many of the clinical symptoms of schizophrenia, i...
#1Ang Li (CAS: Chinese Academy of Sciences)H-Index: 4
#2Andrew Zalesky (University of Melbourne)H-Index: 45
Last. Guangxiang Rao (CAS: Chinese Academy of Sciences)H-Index: 1
view all 40 authors...
Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia1–5. We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification, prognosis and subtyping based on functional striatal abnormalities (FSA). FSA scores provide a personalized index of striatal dysfunction, ranging from normal to highly pathological. Using inter-site cross-validation on functional magnetic resonance images acquired from seven independent scan...
4 CitationsSource
#1W. Liu (KIZ: Kunming Institute of Zoology)H-Index: 4
#2Wenqiang Li (Xinxiang Medical University)H-Index: 13
Last. Chen Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 25
view all 21 authors...
Genome-wide association studies (GWAS) have reported substantial single-nucleotide polymorphisms (SNPs) associated with major depressive disorder (MDD), but the underlying functional variations in the GWAS risk loci are unclear. Here we show that the European MDD genome-wide risk-associated allele of rs12129573 at 1p31.1 is associated with MDD in Han Chinese, and this SNP is in strong linkage disequilibrium (LD) with a human-unique Alu insertion polymorphism (rs70959274) in the 5′ flanking regio...
2 CitationsSource
#1Kun Li (Xinxiang Medical University)H-Index: 1
#2Haisan Zhang (Xinxiang Medical University)H-Index: 6
Last. Hongxing Zhang (Xinxiang Medical University)H-Index: 13
view all 10 authors...
Objectives: Anxiety is a very common symptom and closely related to obsessive-compulsive symptoms in obsessive-compulsive disorder (OCD). However, the association between anxiety and obsessive-compulsive symptoms at the hippocampus network level remains unclear.Methods: This study enrolled 42 patients with OCD and 42 healthy controls (HCs), who underwent resting-state functional magnetic resonance imaging (fMRI) and clinical evaluation. Multiple linear regression analysis was performed to invest...
#1Yue Cui (CAS: Chinese Academy of Sciences)H-Index: 15
#2Jiahao Dong (BISTU: Beijing Information Science & Technology University)H-Index: 1
Last. Tianzi JiangH-Index: 69
view all 11 authors...
Abstract Background White matter abnormalities have been implicated in mental disorders including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ); however, the shared and distinct white matter integrity across mental disorders is still unclear. Methods A total of 290 participants (MDD = 85, BD = 42, SZ = 68, and healthy controls = 95) were included in the present study. Tract-based spatial statistics were performed to measure fractional anisotropy (FA) and characte...
2 CitationsSource
#1Sen Zhang (Xinxiang Medical University)H-Index: 1
#2Ge Yang (Xinxiang Medical University)H-Index: 22
Last. Luxian Lv (Xinxiang Medical University)H-Index: 20
view all 11 authors...
Abstract The default mode network (DMN), is one of the most popularly employed resting-state networks applied in schizophrenia (SCZ) research. However, the homogeneity of this network in adolescent-onset SCZ (AOS) remains unknown. This study aims to use network homogeneity (NH) to explore the functional connectivity in the DMN of AOS patients. Resting-state functional magnetic resonance imaging scans were used to study 48 drug-naive, first-episode AOS patients and 31 healthy age, gender, and edu...
1 CitationsSource