John Lyman
University of California, Berkeley
Publications 158
#1Lynn Verhey (Harvard University)H-Index: 36
#2John Lyman (LBNL: Lawrence Berkeley National Laboratory)H-Index: 31
The AAPM recommendations regarding the w values for heavy charged‐particles radiotherapy are discussed. (AIP)
18 CitationsSource
#1Jacob I. Fabrikant (University of California, Berkeley)H-Index: 20
#2Richard P. Levy (University of California, Berkeley)H-Index: 26
Last.Gerald D. Silverberg (Stanford University)H-Index: 36
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Under multi-institutional-approved protocols, nearly 400 patients with surgically inaccessible intracranial vascular malformations have been treated with stereotactic heavy charged-particle Bragg peak radiosurgery at the University of California, Berkeley, Lawrence Berkeley Laboratory. Results on relationships between dose, volume, AVM obliteration, clinical grade, and complication after stereotactic heavy charged-particle radiosurgery are presented and discussed, with special emphasis on detail...
68 CitationsSource
Abstract Because of the large amount of data generated by 31) treatment planning, new tools are being developed for the evaluation and optimization of the plans. Estimates of the probability of local control of the tumor and for the probability of specific normal tissue complications are among the new tools. The normal tissue complication probability (NTCP) is based on clinical estimates of the tolerance doses for specific tissues/organs. These tolerance doses are assumed to apply for uniform pa...
37 CitationsSource
#1John Lyman (University of California, Berkeley)H-Index: 31
#2Mark H. Phillips (University of California, Berkeley)H-Index: 29
Last.Jacob I. Fabrikant (University of California, Berkeley)H-Index: 20
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For the particles and energies considered suitable for radiosurgery, with increasing particle charge, the Bragg peak height reaches a maximum with helium and then decreases, the Bragg peak width narrows, the distal fall-off steepens, and the exit dose increases (Table 1). The helium-ion beam is superior to a proton beam because of the higher peak-plateau ratio, more rapid dose fall-off, and smaller beam deflection, and it suffers only in the modest exit dose. Comparison of the therapeutically us...
20 CitationsSource
#1John LymanH-Index: 31
Last.Clifford K. WongH-Index: 3
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Abstract : Networking of information sources in relation to an organizing center is often a requirement for finding solutions to problems that individuals cannot solve alone. The process may require ongoing situation assessment by the problem-solving participants and the sharing of assessment progress via transfer of information over physically restricted communication links. the communication process may occur under conditions in which the participants are stressed. In the experiment reported i...
#1Mark H. PhillipsH-Index: 29
#2Marc L. Kessler (UM: University of Michigan)H-Index: 39
Last.Richard P. LevyH-Index: 26
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Magnetic resonance imaging (MRI) has been incorporated with stereotactic cerebral angiography and computed tomography (CT) in the treatment planning process of heavy ion radiosurgery of intracranial arteriovenous malformations (AVM's). Correlation of the images of the AVM and normal tissue on each of these neuroradiological imaging modalities is achieved by means of fiducial markers. The computerized transfer of angiographic information to the CT images regarding the size, shape, and location of...
54 CitationsSource
#1Theodore S. Lawrence (UM: University of Michigan)H-Index: 11
#2R.K. Ten Haken (UM: University of Michigan)H-Index: 68
Last.Allen S. Lichter (UM: University of Michigan)H-Index: 3
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Although it is well known that the tolerance of the liver to external beam irradiation depends on the volume of liver irradiated, few data exist which quantify this dependence. Therefore, a review was carried out of our clinical trial for the treatment of intrahepatic malignancies in which the dose of radiation delivered depended on the volume of normal liver treated. Three dimensional treatment planning using dose-volume histogram analysis of the normal liver was used for all patients. Nine of ...
293 CitationsSource
#1Jacob I. Fabrikant (University of California, Berkeley)H-Index: 20
#2Richard P. Levy (University of California, Berkeley)H-Index: 26
Last.John Lyman (University of California, Berkeley)H-Index: 31
view all 7 authors...
We have treated over 400 patients with symptomatic inoperable intracranial arteriovenous malformations (AVMs) with stereotactic heavy-charged-particle Bragg peak radiosurgery at the University of Cali
17 CitationsSource
2 CitationsSource
#1John F Dicello (Clarkson University)H-Index: 7
#2John Lyman (LBNL: Lawrence Berkeley National Laboratory)H-Index: 31
Last.Lynn Verhey (Harvard University)H-Index: 36
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Abstract Variations in the physical properties of beams of radiation used for therapy can produce corresponding variations in the patient responses for the same physical dose. These variations have been particularly significant in the application of heavy-charged-particle beams to the clinic. A dedicated system has been designed and constructed, in order to establish a systematic method for the intercomparison of the microdosimetric properties of the various beams being used in clinical trials.
5 CitationsSource