Damien A. Fair
Oregon Health & Science University
Publications 124
Abstract The 21-site Adolescent Brain Cognitive Development (ABCD) study provides an unparalleled opportunity to characterize functional brain development via resting-state functional connectivity (RSFC) and to quantify relationships between RSFC and behavior. This multi-site data set includes potentially confounding sources of variance, such as differences between data collection sites and/or scanner manufacturers, in addition to those inherent to RSFC (e.g., head motion). The ABCD project prov...
#1Joel T. Nigg (OHSU: Oregon Health & Science University)H-Index: 75
#2Sarah L. Karalunas (OHSU: Oregon Health & Science University)H-Index: 14
Last.Beth Wilmot (OHSU: Oregon Health & Science University)H-Index: 16
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#1Jessica RaperH-Index: 10
Last.Eric EarlH-Index: 7
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Considering the impact that Zika virus (ZIKV) infection has on the fetal nervous system and given that the postnatal period is also a time of rapid brain growth, it is important to understand the potential neurobehavioral consequences of ZIKV infection during infancy. Using a rhesus macaque (RM) model, we showed that postnatal ZIKV infection resulted in long-term behavioral changes, including increased emotional reactivity, decreased social contact, loss of balance, and deficits in visual recogn...
#1Zsofia Kovacs-Balint (Yerkes National Primate Research Center)H-Index: 2
#2Eric Feczko (Emory University)H-Index: 16
Last.J Steele (Yerkes National Primate Research Center)
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#1Zaixu Cui (UPenn: University of Pennsylvania)H-Index: 1
#2Hongming Li (UPenn: University of Pennsylvania)H-Index: 3
Last.Tyler M. Moore (UPenn: University of Pennsylvania)H-Index: 20
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The spatial distribution of large-scale functional networks on the anatomic cortex differs between individuals, and is particularly variable in networks responsible for executive function. However, it remains unknown how this functional topography evolves in development and supports cognition. Capitalizing upon advances in machine learning and a large sample of youth (n=693, ages 8-23y) imaged with 27 minutes of high-quality fMRI data, we delineate how functional topography evolves during youth....
#1Ting Xu (MIND Institute)H-Index: 4
#2Karl-Heinz Nenning (Medical University of Vienna)H-Index: 3
Last.Michael P. Milham (MIND Institute)H-Index: 70
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Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes to brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other spec...
#1Eric Feczko (OHSU: Oregon Health & Science University)H-Index: 16
#2Oscar Miranda-Dominguez (OHSU: Oregon Health & Science University)H-Index: 7
Last.Damien A. Fair (OHSU: Oregon Health & Science University)H-Index: 43
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The imprecise nature of psychiatric nosology restricts progress towards characterizing and treating mental health disorders. One issue is the ‘heterogeneity problem’: different causal mechanisms may relate to the same disorder, and multiple outcomes of interest can occur within one individual. Our review tackles this heterogeneity problem, providing considerations, concepts, and approaches for investigators examining human cognition and mental health. We highlight the difficulty of pure dimensio...