Match!
Melissa Tuck
University of Michigan
14Publications
6H-index
1,419Citations
Publications 14
Newest
#1Melissa TuckH-Index: 6
#2D. Kim TurgeonH-Index: 17
Last.Dean E. BrennerH-Index: 49
view all 3 authors...
#1Melissa Tuck (UM: University of Michigan)H-Index: 6
#2D. Kim Turgeon (UM: University of Michigan)H-Index: 17
Last.Dean E. Brenner (UM: University of Michigan)H-Index: 49
view all 3 authors...
Starting with properly collected, processed, annotated, and stored human specimens is critical for successful research using unsupervised, high-throughput technologies for discovery, validation, and translation from such samples. Samples that are not reproducibly collected and managed undermine data generated in platforms, such as mass spectroscopy–based proteomic technologies. The key factors that determine quality of human biosamples are use of consistent methodologies for collection, handling...
#1Mack T. Ruffin (UM: University of Michigan)H-Index: 37
#2Daniel P. Normolle (University of Pittsburgh)H-Index: 51
Last.Dean E. Brenner (UM: University of Michigan)H-Index: 49
view all 10 authors...
The galactose oxidase-Schiff (GOS) reaction detects D-galactose-β-[1,3]-N-acetyl-D-galactosamine. This is a T-antigen expressed in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Previous studies using a qualitative GOS assay proved to be of limited value for the detection of colorectal neoplasia. We used a newly developed quantitative GOS assay to determine its potential as an early detection biomarker for colorectal cancer. We completed a multi-center...
#1Madhuri Kakarala (UM: University of Michigan)H-Index: 10
#2Robert E. Carroll (UIC: University of Illinois at Chicago)H-Index: 14
Last.Dean E. Brenner (UM: University of Michigan)H-Index: 49
view all 7 authors...
Background: Curcumin, a dietary polyphenol derivative of turmeric, has potent cancer reductive activity in in vivo colon carcinogenesis models. We administered curcumin at doses of 2 g or 4 g to separate groups of 20 healthy human smokers with > 8 aberrant crypt foci (ACF). The 2 g dose showed no ACF reduction while the 4 g dose showed a 46% reduction (p Methods: Curcuminoid products were extracted from homogenized biopsy tissue and ultacentrifuged plasma and evaporated under argon. The separati...
#1Robert E. Carroll (UIC: University of Illinois at Chicago)H-Index: 14
#2D.K. Turgeon (UM: University of Michigan)H-Index: 10
Last.Dean E. Brenner (UM: University of Michigan)H-Index: 49
view all 9 authors...
Curcumin, a dietary polyphenol derivative of turmeric, has potent cancer preventive activity in in vivo colon carcinogenesis models. To determine whether curcumin has pharmacodynamic effects on the human colon, we administered curcumin at doses of 2 g or 4 g to separate groups of 20 healthy human smokers who had 8 or more aberrant crypt foci on screening colonoscopy. We removed 3 aberrant crypt foci and 4 flat mucosal biopsies under magnifying endoscopy prior to and after 28 days of daily curcum...
#1Mark S. Kaminski (UM: University of Michigan)H-Index: 44
#2Melissa Tuck (UM: University of Michigan)H-Index: 6
Last.Richard L. Wahl (Johns Hopkins University)H-Index: 85
view all 10 authors...
Abstract 3759 Poster Board III-695 Purpose Tositumomab and iodine I 131 tositumomab (Bexxar® Therapeutic Regimen) has been found effective in relapsed/refractory follicular lymphoma. We now report updated results of a single center, single-arm, Phase II trial of a single one-week course of this treatment for 76 previously untreated, stage III and IV, follicular lymphoma patients (reporting period June 1996 to May 2009). Patients and Methods Patients had a median age of 49 years (range 23 to 69) ...
#1Melissa Tuck (UM: University of Michigan)H-Index: 6
#2Daniel Wan-Yui ChanH-Index: 77
Last.Dean E. Brenner (UM: University of Michigan)H-Index: 49
view all 12 authors...
Specimen collection is an integral component of clinical research. Specimens from subjects with various stages of cancers or other conditions, as well as those without disease, are critical tools in the hunt for biomarkers, predictors, or tests that will detect serious diseases earlier or more readily than currently possible. Analytic methodologies evolve quickly. Access to high-quality specimens, collected and handled in standardized ways that minimize potential bias or confounding factors, is ...
#1Mark S. Kaminski (UM: University of Michigan)H-Index: 44
#2Melissa Tuck (UM: University of Michigan)H-Index: 6
Last.Richard L. Wahl (Johns Hopkins University)H-Index: 85
view all 11 authors...
Background Advanced-stage follicular B-cell lymphoma is considered incurable. Anti-CD20 radioimmunotherapy is effective in patients who have had a relapse after chemotherapy or who have refractory follicular lymphoma, but it has not been tested in previously untreated patients. Methods Seventy-six patients with stage III or IV follicular lymphoma received as initial therapy a single course of treatment with 131I-tositumomab therapy (registered as Tositumomab and Iodine I 131 Tositumomab [the Bex...
12