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Matthias Pawlowski
University of Cambridge
PathologyNeuroscienceFrontotemporal dementiaMedicineBiology
19Publications
7H-index
228Citations
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Publications 20
Newest
#1Anna M. SpeicherH-Index: 1
#2Heinz WiendlH-Index: 43
Last. Matthias PawlowskiH-Index: 7
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Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance of numerous diseases affecting the CNS. Previous in vitro research on human microglia was restricted to post-mortem brain tissue-derived microglia, with limited availability and lack of scalability. Recently, the first protocols for the generation of microglia from human pluripotent stem cells have become available, thus enabling the impl...
1 CitationsSource
Objectives Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome linked to diverse types of underlying neuropathology. Diagnosis is mainly based on clinical presentation and accurate prediction of underlying neuropathology remains difficult. Methods We present a large cohort of patients with FTD spectrum diseases (n=84). All patients were thoroughly characterised by cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers, neuroimaging, neuropsychological testing and standardis...
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#2Thomas MarianH-Index: 4
Last. Tobias WarneckeH-Index: 24
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Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of patients with impaired cough reflex and in advanced stages of PD. The aim of the study was to investigate SP in PD patients in order to gain further insights into the underlying patho...
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Background: Parkinson’s disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. Methods: In this study, we performed comprehensive immune cell profiling in the cerebrospinal fluid (CSF) and peripheral blood (PB) of PD patients. Ten PD patients were diagnosed according to brain bank criteria and underwent detailed clinical examination, magnetic resonance imaging, PB and CSF immune cell profiling by multiparame...
4 CitationsSource
Background Niemann-Pick disease type C (NP-C) is a rare, progressive neurodegenerative disease caused by mutations in the NPC1 or the NPC2 gene. Neurocognitive deficits are common in NP-C, particularly in patients with the adolescent/adult-onset form. As a disease-specific therapy is available, it is important to distinguish clinically between the cognitive profiles in NP-C and primary dementia (e.g., early Alzheimer’s disease; eAD).
1 CitationsSource
#1Julia KrämerH-Index: 6
#2Gero LuegH-Index: 2
Last. Thomas DuningH-Index: 25
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1 CitationsSource
#1Matthias PawlowskiH-Index: 7
#2Gero LuegH-Index: 2
Last. Thomas DuningH-Index: 25
view all 9 authors...
Abstract Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. In this study, we performed comprehensive immune cell profiling in the cerebrospinal fluid (CSF) and peripheral blood of patients with FTD. Thirty-two patients with behavioral variant frontotemporal dementia and 25 patients with primary progressive aphasia were included and compared to 14 healthy elderly controls. All pat...
1 CitationsSource
#1Alessandro Bertero (University of Cambridge)H-Index: 14
#2Loukia Yiangou (University of Cambridge)H-Index: 4
Last. Ludovic Vallier (University of Cambridge)H-Index: 43
view all 6 authors...
2 CitationsSource
#1Matthias PawlowskiH-Index: 7
#2Sven G. MeuthH-Index: 37
Last. Thomas DuningH-Index: 25
view all 3 authors...
Alzheimer’s disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer’s disease. In parallel, assays for the detection of biomarkers that reflect the typical Alzheimer’s disease-associated pathology have been developed and validated in myriads of clinical studies. Such biomarkers complement clinical diagnosis and improve diagnostic accuracy. T...
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#1Fotios Sampaziotis (Cambridge University Hospitals NHS Foundation Trust)H-Index: 8
#2Alexander W. Justin (University of Cambridge)H-Index: 4
Last. Ludovic Vallier (Wellcome Trust Sanger Institute)H-Index: 43
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Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them in mouse models may provide a way to overcome this limitation.
45 CitationsSource
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