Allan Bradley
Wellcome Trust Sanger Institute
GeneMolecular biologyMutationGeneticsBiology
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Publications 354
#1David Oyen (Scripps Research Institute)H-Index: 7
#2Jonathan L. Torres (Scripps Research Institute)H-Index: 9
Last. Qi LiangH-Index: 8
view all 19 authors...
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies studied to date interact with the central NANP repeat region of PfCSP. However, it remains unclear what structural and functional characteristics correlate with better protection by one antibody over another. Binding to the junctional region between t...
#1M.Z. Cader (University of Cambridge)
#1M Zaeem CaderH-Index: 3
Last. Arthur KaserH-Index: 58
view all 22 authors...
Summary Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases the risk for Crohn's disease and leprosy. We developed an unbiased liquid chromatography-mass spectrometry screen for enzymatic activity of this orphan protein. We report that FAMIN phosphorolytically cleaves adenosine into adenine and ribose-1-phosphate. Such activity was considered absent from eukaryotic metabolism. FAMIN and its prokaryotic orthologs additionall...
#1Tao Zhang (Soochow University (Suzhou))
#2Pancheng Xie (Soochow University (Suzhou))H-Index: 4
Last. Ying Xu (Soochow University (Suzhou))H-Index: 32
view all 37 authors...
Circadian systems provide a fitness advantage to organisms by allowing them to adapt to daily changes of environmental cues, such as light/dark cycles. The molecular mechanism underlying the circadian clock has been well characterized. However, how internal circadian clocks are entrained with regular daily light/dark cycles remains unclear. By collecting and analyzing indirect calorimetry (IC) data from more than 2000 wild-type mice available from the International Mouse Phenotyping Consortium (...
#1Marie-Christine Birling (UDS: University of Strasbourg)H-Index: 13
#2Atsushi YoshikiH-Index: 33
Last. Stephen A. MurrayH-Index: 31
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The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes from targeted embryonic stem cells on the C57BL/6N genetic background. This includes 2,850 null alleles for which no equivalent mutant mouse line exists, 2,987 novel conditional-ready alleles, and 4,433 novel reporter alleles. This nearly triples the number of genes with reporter alleles and almost doubles the number of conditional alleles available to the scientific community. ...
2 CitationsSource
#1Amy T. Y. YeungH-Index: 9
#2Yoon Ha Choi (DGIST: Daegu Gyeongbuk Institute of Science and Technology)H-Index: 1
Last. Gordon Dougan (University of Cambridge)H-Index: 104
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ABSTRACT A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR3A, CYFIP2, CTTN, and NHLRC2), glycosaminoglycan metabolism (B3GNT1), receptor signaling (PDGFB and CD27), lipid raft formation (CLTCL1), calcium transport (ATP2A2 and ITPR3), and cholesterol...
1 CitationsSource
#1Alina Rudorf (DKFZ: German Cancer Research Center)H-Index: 1
#2Tony Andreas Müller (University of Freiburg)H-Index: 2
Last. Anna Lena Illert (DKFZ: German Cancer Research Center)H-Index: 7
view all 16 authors...
Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine kinase domain (TKD), but the biological mechanism underlying this effect remains unclear. In the present study, we investigated the effect of the coincidence of NPM1c and FLT3-TKD. Although expressio...
#1Wei WangH-Index: 42
#1Wei WangH-Index: 23
Last. E-Chiang LeeH-Index: 13
view all 21 authors...
#1Wei WangH-Index: 9
#1Wei WangH-Index: 43
view all 13 authors...