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Andre G. Machado
Cleveland Clinic
NeuroscienceStimulationDeep brain stimulationAnesthesiaMedicine
223Publications
27H-index
4,592Citations
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Publications 214
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#1Jerrold L. Vitek (UMN: University of Minnesota)H-Index: 63
#2Roshini JainH-Index: 3
Last. Donald Whiting (Allegheny General Hospital)H-Index: 14
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Summary Background Deep brain stimulation (DBS) of the subthalamic nucleus is an established therapeutic option for managing motor symptoms of Parkinson's disease. We conducted a double-blind, sham-controlled, randomised controlled trial to assess subthalamic nucleus DBS, with a novel multiple independent contact current-controlled (MICC) device, in patients with Parkinson's disease. Methods This trial took place at 23 implanting centres in the USA. Key inclusion criteria were age between 22 and...
2 CitationsSource
#1Kamal MaheshwariH-Index: 8
#2Rafi AvitsianH-Index: 11
Last. Sandra MachadoH-Index: 1
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BACKGROUND: Various multimodal analgesic approaches have been proposed for spine surgery. The authors evaluated the effect of using a combination of four nonopioid analgesics versus placebo on Quality of Recovery, postoperative opioid consumption, and pain scores. METHODS: Adults having multilevel spine surgery who were at high risk for postoperative pain were double-blind randomized to placebos or the combination of single preoperative oral doses of acetaminophen 1,000 mg and gabapentin 600 mg,...
2 CitationsSource
#1Ki-Hyun Cho (Cleveland Clinic)H-Index: 7
#2Hirsh Shah (Cleveland Clinic)
Last. Francis Papay (Cleveland Clinic)H-Index: 18
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OBJECTIVE: Neuromodulation for trigeminal pain syndromes such as trigeminal neuropathic pain (TNP) necessitates accurate localization of foramen ovale (FO). The Hartel-type approach is very well-established and safe, ideal for temporary cannulation of the FO for ablative procedures such as balloon microcompression. A key shortcoming of the Hartel approach for placement of neuromodulation leads is the limited opportunity for secure anchoring. The aim of this study is to introduce a novel surgical...
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#2Andre G. MachadoH-Index: 27
Last. Leonardo G. CohenH-Index: 116
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Background: Repetitive peripheral nerve sensory stimulation (RPSS) has emerged as a potential adjuvant strategy to motor training in stroke rehabilitation. The aim of this study is to test the hypothesis that 3-hour sessions of active RPSS associated with functional electrical stimulation (FES) and task-specific training (TST) distributed three times a week, over six weeks, is more beneficial to improve upper limb motor function than sham RPSS in addition to FES and TST, in subjects with moderat...
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#2Brett A. Campbell (Case Western Reserve University)
Last. Kenneth B. Baker (Case Western Reserve University)
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OBJECTIVE: Deep brain stimulation (DBS) is an effective therapy for different neurological diseases, despite the lack of comprehension of its mechanism of action. The use of nonhuman primates (NHPs) has been historically important in advancing this field and presents a unique opportunity to uncover the therapeutic mechanisms of DBS, opening the way for optimization of current applications and the development of new ones. To be informative, research using NHPs should make use of appropriate elect...
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#1Jessica Cooperrider (Cleveland Clinic Lerner College of Medicine)
#1Jessica Cooperrider (Cleveland Clinic Lerner College of Medicine)
Last. Andre G. MachadoH-Index: 27
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This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation. We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating denta...
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OBJECTIVE: Parkinson's disease (PD) is a progressive neurological movement disorder that is commonly treated with deep brain stimulation (DBS) surgery in advanced stages. The purpose of this study was to investigate factors that affect time to placement of a second-sided DBS lead for PD when a unilateral lead is initially placed for asymmetrical presentation. The decision whether to initially perform unilateral or bilateral DBS is largely based on physician and/or patient preference. METHODS: Th...
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Abstract Introduction Deep brain stimulation (DBS) is a widely accepted therapy for Parkinson's disease. While outcome predictors such as levodopa-response are well established, there remains a need for objective and unbiased predictors in clinical practice. We performed an exploratory study to examine whether cortical thickness, derived from preoperative MRI, correlates with postoperative outcome. Methods Using freesurfer, we retrospectively measured cortical thickness on the preoperative MRI o...
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#1Sara DavinH-Index: 5
#2Brittany LapinH-Index: 18
Last. Irene L. KatzanH-Index: 29
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STUDY DESIGN: This is an observational cohort study. OBJECTIVE: The aim of this study was to compare the effectiveness of PT to an interdisciplinary treatment approach in patients with chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA: CLBP is a costly and potentially disabling condition. Physical therapy (PT), cognitive behavioral therapy, and interdisciplinary pain programs (IPPs) are superior to usual care. Empirical evidence is lacking to clearly support one treatment approach over an...
1 CitationsSource
#1Shehryar Sheikh (Cleveland Clinic Lerner College of Medicine)
#2Nicolas R. Thompson (Cleveland Clinic)H-Index: 10
Last. Lara E Jehi (Cleveland Clinic)H-Index: 24
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