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Don P. Wolf
Oregon National Primate Research Center
167Publications
42H-index
5,210Citations
Publications 167
Newest
Published on Jun 3, 2019in Nature Medicine 30.64
Don P. Wolf42
Estimated H-index: 42
(OHSU: Oregon Health & Science University),
Paul A. Mitalipov (OHSU: Oregon Health & Science University), Shoukhrat Mitalipov36
Estimated H-index: 36
(OHSU: Oregon Health & Science University)
Monogenic disorders occur at a high frequency in human populations and are commonly inherited through the germline. Unfortunately, once the mutation has been transmitted to a child, only limited treatment options are available in most cases. However, means of correcting disease-causing nuclear and mitochondrial DNA mutations in gametes or preimplantation embryos have now been developed and are commonly referred to as germline gene therapy (GGT). We will discuss these novel strategies and provide...
Published on Mar 1, 2019in Nature 43.07
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Published on Sep 11, 2018
Hong Ma27
Estimated H-index: 27
,
Nuria Marti-Gutierrez1
Estimated H-index: 1
+ 27 AuthorsRiffat Ahmed10
Estimated H-index: 10
Published on Jul 24, 2018in PLOS ONE 2.78
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
Published on Nov 1, 2017in Journal of Assisted Reproduction and Genetics 2.82
David M. Lee55
Estimated H-index: 55
(OHSU: Oregon Health & Science University),
Carrie M. Thomas1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 5 AuthorsMary B. Zelinski19
Estimated H-index: 19
(OHSU: Oregon Health & Science University)
Purpose The main purposes of the study were to investigate the endocrine function of ovarian tissue transplanted to heterotopic subcutaneous sites and the reproductive competence and telomere length of a nonhuman primate originating from transplanted tissue.
Published on Aug 1, 2017in The EMBO Journal 11.23
Don P. Wolf42
Estimated H-index: 42
(OHSU: Oregon Health & Science University),
Tomonari Hayama8
Estimated H-index: 8
(OHSU: Oregon Health & Science University),
Shoukhrat Mitalipov36
Estimated H-index: 36
(OHSU: Oregon Health & Science University)
Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell9s energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see ...
Published on Aug 1, 2017in Nature 43.07
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
Published on Jan 1, 2017in Cell Stem Cell 21.46
Hong Ma27
Estimated H-index: 27
(OHSU: Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(UCSD: University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
Published on Jan 1, 2017in Stem Cells 5.61
Don P. Wolf42
Estimated H-index: 42
,
Robert Morey9
Estimated H-index: 9
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
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