Match!
Don P. Wolf
Oregon Health & Science University
165Publications
42H-index
5,452Citations
Publications 163
Newest
#1Don P. Wolf (OHSU: Oregon Health & Science University)H-Index: 42
#2Paul A. Mitalipov (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 3 authors...
Monogenic disorders occur at a high frequency in human populations and are commonly inherited through the germline. Unfortunately, once the mutation has been transmitted to a child, only limited treatment options are available in most cases. However, means of correcting disease-causing nuclear and mitochondrial DNA mutations in gametes or preimplantation embryos have now been developed and are commonly referred to as germline gene therapy (GGT). We will discuss these novel strategies and provide...
1 CitationsSource
#1Eunju Kang (Oregon National Primate Research Center)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
2 CitationsSource
#1Hong MaH-Index: 27
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Source
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Yeonmi Lee (Oregon National Primate Research Center)H-Index: 6
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 15 authors...
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
1 CitationsSource
#1David M. Lee (OHSU: Oregon Health & Science University)H-Index: 54
#2Carrie M. Thomas (OHSU: Oregon Health & Science University)H-Index: 1
Last.Mary B. Zelinski (OHSU: Oregon Health & Science University)H-Index: 19
view all 8 authors...
Purpose The main purposes of the study were to investigate the endocrine function of ovarian tissue transplanted to heterotopic subcutaneous sites and the reproductive competence and telomere length of a nonhuman primate originating from transplanted tissue.
2 CitationsSource
#1Don P. WolfH-Index: 42
#2Tomonari HayamaH-Index: 8
Last.Shoukhrat MitalipovH-Index: 36
view all 3 authors...
4 CitationsSource
#1Don P. Wolf (OHSU: Oregon Health & Science University)H-Index: 42
#2Tomonari Hayama (OHSU: Oregon Health & Science University)H-Index: 8
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 3 authors...
Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell9s energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see ...
13 CitationsSource
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat MitalipovH-Index: 36
view all 31 authors...
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
328 CitationsSource
#1Hong Ma (OHSU: Oregon Health & Science University)H-Index: 27
#2Ryan C. O’Neil (UCSD: University of California, San Diego)H-Index: 5
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 26 authors...
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
25 CitationsSource
#1Don P. WolfH-Index: 42
#2Robert MoreyH-Index: 10
Last.Shoukhrat MitalipovH-Index: 36
view all 7 authors...
Author(s): Wolf, Don P; Morey, Robert; Kang, Eunju; Ma, Hong; Hayama, Tomonari; Laurent, Louise C; Mitalipov, Shoukhrat | Abstract: Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use...
10 CitationsSource
12345678910