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Ashwin Sachdeva
Newcastle University
25Publications
8H-index
611Citations
Publications 25
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#1Matthew BrownH-Index: 8
#2Claire A HartH-Index: 21
Last.Noel W. ClarkeH-Index: 53
view all 5 authors...
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#1Ashwin SachdevaH-Index: 8
#2Claire A HartH-Index: 21
Last.Noel W. ClarkeH-Index: 53
view all 9 authors...
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#1Craig Stamp (Newcastle University)H-Index: 3
#2Anze Zupanic (Eawag: Swiss Federal Institute of Aquatic Science and Technology)H-Index: 14
Last.Laura C. Greaves (Newcastle University)H-Index: 24
view all 11 authors...
Abstract Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the predominant mode of SC self-renewal and the rate of SC replacement. Here we use age-related mitochondrial oxidative phosphorylation (OXPHOS) defects to trace clonal lineages within human colorectal crypts across the adult life-course. By resolving the frequency and size distribution of OXPHOS-deficient clones, quantitative analysis show...
6 CitationsSource
#1Francesco Canfarotta (University of Leicester)H-Index: 9
#2Joanna Czulak (University of Leicester)H-Index: 3
Last.Marloes Peeters (MMU: Manchester Metropolitan University)H-Index: 16
view all 8 authors...
Molecularly Imprinted Polymers (MIPs) are synthetic receptors that are able to selectively bind their target molecule and, for this reason, they are currently employed as recognition elements in sensors. In this work, MIP nanoparticles (nanoMIPs) are produced by solid-phase synthesis for a range of templates with different sizes, including a small molecule (biotin), two peptides (one derived from the epithelial growth factor receptor and vancomycin) and a protein (trypsin). NanoMIPs are then dip...
8 CitationsSource
#1Ashwin Sachdeva (Newcastle University)H-Index: 8
#2Rajan Veeratterapillay (Newcastle upon Tyne Hospitals NHS Foundation Trust)H-Index: 11
Last.Naeem Soomro (Newcastle University)H-Index: 18
view all 7 authors...
Positive surgical margins are a strong prognostic marker of disease outcome following radical prostatectomy, though prior evidence is largely from a PSA-screened population. We therefore aim to evaluate the biochemical recurrence in men with positive surgical margins (PSM) after minimally-invasive radical prostatectomy (MIRP) in a UK tertiary centre. Retrospective study of men undergoing laparoscopic or robotic-assisted radical prostatectomy between 2002 and 2014. Men with positive surgical marg...
2 CitationsSource
#1Ashwin SachdevaH-Index: 8
#2Amira El-SherifH-Index: 6
Last.Rakesh HeerH-Index: 16
view all 5 authors...
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#1Lay Ping Ong (Freeman Hospital)H-Index: 2
#2Ashwin Sachdeva (Freeman Hospital)H-Index: 8
Last.Stephen Clark (Freeman Hospital)H-Index: 26
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Background Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postoperative morbidity and mortality. We investigated the impact of allogeneic blood transfusion on rejection, function, and late mortality within lung transplantation. Methods A retrospective review was made of 311 adult patients who underwent bilateral lung transplantation with cardiopulmonar...
8 CitationsSource
#1Lay Ping Ong (Freeman Hospital)H-Index: 2
#2Emily R Thompson (Freeman Hospital)H-Index: 2
Last.Stephen Clark (Freeman Hospital)H-Index: 26
view all 8 authors...
Objectives: Blood transfusion is associated with higher morbidity and mortality after general cardiothoracic surgery but its impact within the transplant population is unclear. We investigated the profile of blood product transfusion in the bilateral lung transplant population and its impact on function and mortality. Methods: Three hundred and eleven adult patients who underwent bilateral lung transplant between 2003 and 2013 were retrospectively reviewed. Patients were stratified according to ...
5 CitationsSource
#1Ashwin Sachdeva (RCS: Royal College of Surgeons of England)H-Index: 8
#2J van der Meulen (RCS: Royal College of Surgeons of England)H-Index: 53
Last.Paul Cathcart (RCS: Royal College of Surgeons of England)H-Index: 16
view all 4 authors...
Objectives: Prostate cancer mortality (PCM) in the USA is among the lowest in the world, whereas PCM in England is among the highest in Europe. This paper aims to assess the association of variation in use of definitive therapy on risk-adjusted PCM in England as compared with the USA. Design: Observational study. Setting: Cancer registry data from England and the USA. Participants: Men diagnosed with non-metastatic prostate cancer (PCa) in England and the USA between 2004 and 2008. Outcome measu...
2 CitationsSource
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