Andrea Mari
National Research Council
EndocrinologyType 2 diabetesInsulin resistanceInsulinDiabetes mellitus
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Publications 213
#1Domenico Tricò (UniPi: University of Pisa)H-Index: 9
#2Alfonso Galderisi (UNIPD: University of Padua)H-Index: 10
Last. Sonia Caprio (Yale University)H-Index: 65
view all 9 authors...
AIMS: Non-Alcoholic Fatty Liver Disease (NAFLD) has been associated with reduced endogenous insulin clearance (EIC) and hepatic insulin resistance (HIRI). These relationships, however, might be differentially affected by the ethnic background, as populations of African ancestry are typically featured with reduced intrahepatic fat content (HFF%) but impaired EIC. Therefore, we evaluated the influence of the ethnicity on the relationships between HFF%, EIC and HIRI. METHODS: The HFF% was quantifie...
#1Eleni Rebelos (UTU: University of Turku)H-Index: 5
#2Andrea Mari (National Research Council)H-Index: 56
Last. Patricia Iozzo (UTU: University of Turku)H-Index: 37
view all 12 authors...
#1Alessandro Mengozzi (UniPi: University of Pisa)H-Index: 2
#2Domenico Tricò (UniPi: University of Pisa)H-Index: 9
view all 9 authors...
Abstract Background/aims Uncertainty still exists on the earliest beta-cell defects at the bases of the type 2 diabetes. We assume that this depends on the inaccurate distinction between fasting and post-load glucose homeostasis and aim at providing a description of major beta-cell functions across the full physiologic spectrum of each condition. Methods In 1320 non-diabetic individuals we performed an OGTT with insulin secretion modeling and a euglycemic insulin clamp, coupled in subgroups to g...
#1Andin Fosam (NIH: National Institutes of Health)
#2Shanaz Sikder (NIH: National Institutes of Health)H-Index: 1
Last. Ranganath Muniyappa (NIH: National Institutes of Health)H-Index: 26
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BACKGROUND: African Americans (AAs) are at a higher risk for developing type 2 diabetes compared with non-Hispanic whites (NHWs). The causal role of beta-cell glucose sensitivity (beta-GS) and insulin clearance in hyperinsulinemia in AA adults is unclear. OBJECTIVE: Using a cross-sectional study design, we compared beta-cell function and insulin clearance in nondiabetic AAs (n = 36) and NHWs (n = 47) after a mixed meal test (MMT). METHODS: Insulin secretion rate, glucose sensitivity, rate sensit...
#1Laura J. Mccreight (Dund.: University of Dundee)H-Index: 3
#2Andrea Mari (National Research Council)H-Index: 56
Last. Ewan R. Pearson (Dund.: University of Dundee)H-Index: 42
view all 6 authors...
1 CitationsSource
#1Robert W. Koivula (University of Oxford)H-Index: 8
#3Naeimeh Atabaki-Pasdar (Lund University)H-Index: 3
Last. Søren Brunak (DTU: Technical University of Denmark)H-Index: 91
view all 34 authors...
It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fat accumulation. Here, we hypothesise that the effect of physical activity in glucose regulation is mediated by the tw...
#1Domenico Tricò (UniPi: University of Pisa)H-Index: 9
#2Alessandro Mengozzi (UniPi: University of Pisa)H-Index: 2
Last. Andrea Natali (UniPi: University of Pisa)H-Index: 48
view all 10 authors...
Aims/hypothesis Experimental studies suggest that the fatty acid palmitoleate may act as an adipocyte-derived lipid hormone (or ‘lipokine’) to regulate systemic metabolism. We investigated the relationship of circulating palmitoleate with insulin sensitivity, beta cell function and glucose tolerance in humans.
#1Domenico Tricò (UniPi: University of Pisa)H-Index: 9
#2Silvia Frascerra (UniPi: University of Pisa)H-Index: 26
Last. Andrea Natali (UniPi: University of Pisa)H-Index: 48
view all 7 authors...
Aims Eating protein before carbohydrate reduces postprandial glucose excursions by enhancing insulin and glucagon-like peptide-1 (GLP-1) secretion in type 2 diabetes (T2D). We tested the hypothesis that this insulinotropic effect depends on the elevation of plasma amino acids (AA) after the digestion of food protein.
4 CitationsSource
#2D. van Dijk (UvA: University of Amsterdam)H-Index: 2
#3Beverley Balkau (University of Paris-Sud)H-Index: 105
Last. Femke Rutters (UvA: University of Amsterdam)H-Index: 14
view all 9 authors...
Aim: Extremes in sleep duration play an important role in the development of type 2 diabetes. We examined the associations between sleep duration and sleep debt with estimates of insulin sensitivity and insulin secretion. Methods: Data were derived from the European multi-centre EGIR-RISC study. Sleep duration and sleep debt were derived from a sleep questionnaire asking about sleeping time during the week and during the weekend. Insulin sensitivity and insulin secretion were estimated from a 2-...
2 CitationsSource
#1Teresa Mezza (UCSC: Catholic University of the Sacred Heart)H-Index: 11
#2Simona Moffa (UCSC: Catholic University of the Sacred Heart)H-Index: 3
Last. Andrea Giaccari (UCSC: Catholic University of the Sacred Heart)H-Index: 30
view all 15 authors...