Arjun Narala
Kakatiya University
PharmacokineticsBioavailabilityChromatographyNasal administrationPharmacology
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Publications 7
#1Dinesh Suram (Kakatiya University)H-Index: 1
#2Arjun Narala (Kakatiya University)H-Index: 2
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 3 authors...
Abstract:Iloperidone (ILO) is an anti-psychotic, used in schizophrenia. It has low bioavailability (36%) due to low solubility and first pass effect. Oral solid self microemulsifying drug delivery ...
#1Arjun Narala (Kakatiya University)H-Index: 2
#2Swathi Guda (Kakatiya University)H-Index: 1
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 3 authors...
Rebamipide has low oral bioavailability (10%) due to its low solubility and permeability. Lipid nanoemulsions (LNEs) were prepared in order to improve its oral bioavailability. Rebamipide-loaded lipid nanoemulsions were formulated by hot homogenization and ultrasonication method. Olive oil and egg lecithin in various concentrations as emulsifier were used in the preparation of LNEs. The lipid nanoemulsions were evaluated for various parameters. The globule size, polydispersity index (PDI), and z...
1 CitationsSource
#1Shravan Kumar Pitta (Kakatiya University)H-Index: 1
#2Narendar Dudhipala (Kakatiya University)H-Index: 5
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
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AbstractThe aim was to prepare an optimized zolmitriptan (ZT)-loaded transfersome formulation using Box–Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal spray. Here, three factors were evaluated at three levels. Independent variables include: amount of soya lecithin (X1), amount of drug (X2) and amount of tween 80 (X3). The dependent responses were vesicle size (Y1), flexibility index (Y2) and regression coe...
2 CitationsSource
Targeting drugs to the brain or Cerebrospinal fluid (CSF) is limited because of the physiological barriers like blood-brain barrier and blood-CSF barriers. Alternative non-invasive, patient compliant delivery routes like intranasal route was investigated by several research groups to target both small and large molecules. Several barriers that limit the bioavailability and research formulation strategies adopted by various research groups are discussed in brief in this review article.
2 CitationsSource
Article history: Received on: 08/06/2015 Revised on: 27/07/2015 Accepted on: 19/08/2015 Available online: 27/09/2015 Objective: The aim of this investigation was the development and characterization of Agomelatin-loaded liquid crystalline (AM-LC) nanoparticles for improved topical application. Methods: AM-LC was formulated with the glyceryl monooleate (GMO) and poloxamer 407 as structure forming agent (lipid) and surfactant respectively, by using emulsification of GMO and poloxamer in water usin...
1 CitationsSource
#1Arjun NaralaH-Index: 2
#2Kishan VeerabrahmaH-Index: 9
Quetiapine fumarate is an antipsychotic drug with poor oral bioavailability (9%) due to first-pass metabolism. Present work is an attempt to improve oral bioavailability of quetiapine fumarate by incorporating in solid lipid nanoparticles (SLN). Six quetiapine fumarate SLN formulations were developed using three different lipids by hot homogenisation followed by ultrasonication. The drug excipient compatibility was studied by differential scanning calorimetry (DSC). Stable quetiapine fumarate SL...
15 CitationsSource
The aim of the present investigation was to formulate and evaluate floating-bioadhesive tablets of amoxicillin trihydrate (ATFBT), to provide local action in the treatment of Helicobacter pylori (H. pylori) by prolonging the gastric residence time. The FBT were prepared by direct compression method using hydroxy propyl methyl cellulose (HPMC K4M) / chitosan (CH), carbopol (CP974P) / polymethacrylic acid (PMA) as release retarding agent / bioadhesive respectively, sodium bicarbonate (NaHCO3) as a...
5 CitationsSource