Susan J. Mandel
University of Pennsylvania
Publications 119
#1Anna M. SawkaH-Index: 25
Last.Jacqueline JonklaasH-Index: 28
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#1Kristen Kobaly (UPenn: University of Pennsylvania)H-Index: 5
#2Susan J. Mandel (UPenn: University of Pennsylvania)H-Index: 48
Clinical hyperthyroidism affects 0.1% to 0.4% of pregnancies. Gestational thyrotoxicosis is due to homology of the structure of TSH and HCG, which weakly stimulates the TSH receptor. Graves’ disease (GD) most commonly causes clinically significant hyperthyroidism. Given concerns for teratogenicity from antithyroid drugs, these may be discontinued in low-risk GD patients. High-risk patients are treated with propylthiouracil in the first trimester then may transition to methimazole. Surgery is res...
#1David L. Steward (UC: University of Cincinnati)H-Index: 44
#2Sally E. Carty (University of Pittsburgh)H-Index: 40
Last.Yuri E. Nikiforov (University of Pittsburgh)H-Index: 68
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Importance Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the nodules are reliably diagnosed as benign without surgery. Objective To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules. Design, Setting, and Participants Prospective, blinded cohort study conducted a...
15 CitationsSource
#1Cosimo DuranteH-Index: 25
#2Giorgio GraniH-Index: 12
Last.David S. Cooper (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 54
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Importance Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. The main goal of initial and long-term follow-up is identification of the small subgroup of nodules that harbor a clinically significant cancer (≈10%), cause compressive symptoms (≈5%), or progress ...
31 CitationsSource
#1Bryan R. Haugen (University of Colorado Denver)H-Index: 47
#2Anna M. Sawka (U of T: University of Toronto)H-Index: 25
Last.Michelle Dianne Williams (University of Texas MD Anderson Cancer Center)H-Index: 37
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American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on, and make recommendations related to the suggested new classification of encapsulated follicular variant papillary thyroid carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with t...
80 CitationsSource
#1Kresimira Milas (UA: University of Arizona)
#2Susan J. Mandel (UPenn: University of Pennsylvania)H-Index: 48
Last.Jill E. Langer (UPenn: University of Pennsylvania)H-Index: 22
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#1Susan J. Mandel (UPenn: University of Pennsylvania)H-Index: 48
Reflections on ultrasound imaging of the thyroid and the neck over more than two decades of use as an endocrinologist trigger both exhilaration and humility, which are persistently coupled as I continue to practice of the art of imaging. Throughout my career, I have been fortunate to partner with and learn from skilled and dedicated colleagues from multiple specialties to provide optimal care for my patients.
#1Anne R. CappolaH-Index: 41
#2Susan J. MandelH-Index: 48
#1Susan J. Mandel (UPenn: University of Pennsylvania)H-Index: 48
Rather than focusing on cancer risks associated with individual sonographic features, pattern recognition relies on the simultaneous presence of several features in a thyroid nodule that together will either increase or decrease suspicion for malignancy. Since 2009, several groups from individual institutions have proposed pattern classification systems, all termed Thyroid Imaging Reporting and Data System (TIRADS). Currently, three main versions of TIRADS exist, with some differences in pattern...
#1Marcia S. BroseH-Index: 33
#2Andrea B. TroxelH-Index: 57
Last.P. J. O'DwyerH-Index: 8
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6002 Background: We are conducting an open-label phase II study of sorafenib in patients with metastatic, iodine-refractory thyroid carcinoma. Methods: 55 Patients were administered sorafenib 400 mg orally BID. Responses were monitored by PET and CT. Primary endpoints were response rate (RR) and progression free survival (PFS) by RECIST criteria. BRAF and RAS mutation status is determined by DNA sequencing. Outcome data is evaluated using the Kaplan-Meier method and log-rank test. Biologic activ...
26 Citations