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Ryan Fredric Bloomquist
Georgia Institute of Technology
9Publications
5H-index
734Citations
Publications 9
Newest
#1Ryan Fredric Bloomquist (Georgia Institute of Technology)H-Index: 5
#2Teresa E. Fowler (Georgia Institute of Technology)H-Index: 3
Last.J. Todd Streelman (Georgia Institute of Technology)H-Index: 27
view all 8 authors...
In Lake Malawi cichlids, each tooth is replaced in one-for-one fashion every ∼20 to 50 d, and taste buds (TBs) are continuously renewed as in mammals. These structures are colocalized in the fish mouth and throat, from the point of initiation through adulthood. Here, we found that replacement teeth (RT) share a continuous band of epithelium with adjacent TBs and that both organs coexpress stem cell factors in subsets of label-retaining cells. We used RNA-seq to characterize transcriptomes of RT ...
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#1Zhengwen An ('KCL': King's College London)H-Index: 4
#2Maja Sabalić ('KCL': King's College London)H-Index: 3
Last.Paul T. Sharpe ('KCL': King's College London)H-Index: 65
view all 6 authors...
The extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1+ MSCs decrease dramatically in number. When adult i...
9 CitationsSource
#1Ryan Fredric Bloomquist (Georgia Regents University)H-Index: 5
#2Teresa E. Fowler (Georgia Institute of Technology)H-Index: 3
Last.J. T. Streelman (Georgia Institute of Technology)H-Index: 1
view all 5 authors...
Abstract Background Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that share similar genomes but differ markedly in phenotypes including brains and behavior, nuptial coloration and the craniofacial skeleton. Research has begun to identify the genes, as well as the molecular and developmental pathways that underlie trait divergence. Results We ...
5 CitationsSource
#1Ryan Fredric Bloomquist (Georgia Regents University)H-Index: 5
#2Nicholas F. Parnell (Georgia Institute of Technology)H-Index: 5
Last.J. Todd Streelman (Georgia Institute of Technology)H-Index: 27
view all 7 authors...
Teeth and taste buds are iteratively patterned structures that line the oro-pharynx of vertebrates. Biologists do not fully understand how teeth and taste buds develop from undifferentiated epithelium or how variation in organ density is regulated. These organs are typically studied independently because of their separate anatomical location in mammals: teeth on the jaw margin and taste buds on the tongue. However, in many aquatic animals like bony fishes, teeth and taste buds are colocalized on...
22 CitationsSource
#1J. Todd Streelman (Georgia Institute of Technology)H-Index: 27
#2Ryan Fredric Bloomquist (Georgia Institute of Technology)H-Index: 5
Last.Teresa E. Fowler (Georgia Institute of Technology)H-Index: 3
view all 3 authors...
In many aquatic vertebrates, including bony and cartilaginous fishes, teeth and taste buds colocalize on jaw elements. In these animals, taste buds are renewed continuously throughout life, whereas teeth undergo cycled whole-organ replacement by various means. Recently, studies of cichlid fishes have yielded new insights into the development and regeneration of these dental and sensory oral organs. Tooth and taste bud densities covary positively across species with different feeding strategies, ...
2 CitationsSource
#1David Brawand (University of Oxford)H-Index: 11
#2Catherine E. WagnerH-Index: 16
Last.Federica Di Palma (Broad Institute)H-Index: 23
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Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lineages of African cichlids: the Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; and four members of the East African lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent...
478 CitationsSource
#1Jason H. Nadler (GTRI: Georgia Tech Research Institute)H-Index: 7
#2Allison J. Mercer (GTRI: Georgia Tech Research Institute)H-Index: 3
Last.Angela Lin (Georgia Institute of Technology)H-Index: 1
view all 6 authors...
Remoras (echeneid fish) reversibly attach and detach to marine hosts, almost instantaneously, to “hitchhike” and feed. The adhesion mechanisms that they use are remarkably insensitive to substrate topology and quite different from the latching and suction cup-based systems associated with other species at similar length scales. Remora adhesion is also anisotropic; drag forces induced by the swimming host increase adhesive strength, while rapid detachment occurs when the remora reverses this shea...
3 CitationsSource
#1Gareth J. Fraser (Georgia Institute of Technology)H-Index: 17
#2C. Darrin Hulsey (UT: University of Tennessee)H-Index: 20
Last.J. Todd Streelman (Georgia Institute of Technology)H-Index: 27
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Vertebrate dentitions originated in the posterior pharynx of jawless fishes more than half a billion years ago. As gnathostomes (jawed vertebrates) evolved, teeth developed on oral jaws and helped to establish the dominance of this lineage on land and in the sea. The advent of oral jaws was facilitated, in part, by absence of hox gene expression in the first, most anterior, pharyngeal arch. Much later in evolutionary time, teleost fishes evolved a novel toothed jaw in the pharynx, the location o...
132 CitationsSource
#1Gareth J. Fraser (Georgia Institute of Technology)H-Index: 17
#2Ryan Fredric Bloomquist (Georgia Institute of Technology)H-Index: 5
Last.J. Todd Streelman (Georgia Institute of Technology)H-Index: 27
view all 3 authors...
Background: Periodic patterning of iterative structures is a fundamental process during embryonic organization and development. Studies have shown how gene networks are employed to pattern butterfly eyespots, fly bristles and vertebrate epithelial appendages such as teeth, feathers, hair and mammary glands. Despite knowledge of how these features are organized, little is known about how diversity in periodic patterning is generated in nature. We address this problem through the molecular analysi...
83 CitationsSource
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