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Elena Hidalgo
Pompeu Fabra University
Molecular biologySchizosaccharomyces pombeGeneticsBiochemistryBiology
83Publications
34H-index
3,349Citations
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Publications 83
Newest
#1Miriam Sansó (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Pabitra K. Parua (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
Last. Jürg Bähler (UCL: University College London)H-Index: 59
view all 12 authors...
Mono-ubiquitylation of histone H2B (H2Bub1) and phosphorylation of elongation factor Spt5 by cyclin-dependent kinase 9 (Cdk9) occur during transcription by RNA polymerase II (RNAPII), and are mutually dependent in fission yeast. It remained unclear whether Cdk9 and H2Bub1 cooperate to regulate the expression of individual genes. Here, we show that Cdk9 inhibition or H2Bub1 loss induces intragenic antisense transcription of ∼10% of fission yeast genes, with each perturbation affecting largely dis...
Source
#1Rodrigo Fraile (UPF: Pompeu Fabra University)
#2Laura Sánchez-Mir (UPF: Pompeu Fabra University)H-Index: 6
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 3 authors...
Survival upon glucose starvation requires a delicate balance between different metabolic pathways. A recent work by the Roe laboratory provides a mechanistic link between glucose deprivation and the regulation of the pentose phosphate pathway, with the transcriptional repressor Rsv1 playing a key role in the process. Rsv1 regulates the flow of glucose into its possible metabolic fates and promotes long-term survival under low glucose.
Source
#1Margarita Cabrera (UPF: Pompeu Fabra University)
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 7 authors...
Summary Cells have developed protein quality-control strategies to manage the accumulation of misfolded substrates during heat stress. Using a soluble reporter of misfolding in fission yeast, Rho1.C17R-GFP, we demonstrate that upon mild heat shock, the reporter collapses in protein aggregate centers (PACs). They contain and/or require several chaperones, such as Hsp104, Hsp16, and the Hsp40/70 couple Mas5/Ssa2. Stress granules do not assemble at mild temperatures and, therefore, are not required...
Source
#1Luis Marte (UPF: Pompeu Fabra University)
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 6 authors...
Abstract Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s). In a screen to search for protein quality control components required for wild-type tolerance to oxidative stress in fission yeast, we have isolated eight gene deletions conferring resistance not only to H2O2 but also to caffeine. We show that dual resistance acquisition is totally or partially dependent on the t...
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#1Carlos Henríquez-Olguín (University of Chile)H-Index: 14
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last. Thomas E. Jensen (UCPH: University of Copenhagen)H-Index: 30
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Abstract Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic health. Reactive oxygen species (ROS) have emerged as intracellular messengers participating in bot...
6 CitationsSource
#1Mercè Carmona (UPF: Pompeu Fabra University)H-Index: 7
#2Laura de Cubas (UPF: Pompeu Fabra University)H-Index: 1
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 9 authors...
Genetically encoded probes monitoring H2O2 fluctuations in living organisms are key to decipher redox signaling events. Here we use a new probe, roGFP2-Tpx1.C169S, to monitor pre-toxic fluctuations of peroxides in fission yeast, where the concentrations linked to signaling or to toxicity have been established. This probe is able to detect nanomolar fluctuations of intracellular H2O2 caused by extracellular peroxides; expression of human aquaporin 8 channels H2O2 entry into fission yeast decreasi...
3 CitationsSource
#1Alberto González-Medina (UPF: Pompeu Fabra University)H-Index: 2
#2Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
Last. José Ayté (UPF: Pompeu Fabra University)H-Index: 25
view all 3 authors...
: In fission yeast, MBF-dependent transcription is inactivated at the end of S phase through a negative feedback loop that involves the co-repressors, Yox1 and Nrm1. Although this repression system is well known, the molecular mechanisms involved in MBF activation remain largely unknown. Compacted chromatin constitutes a barrier to activators accessing promoters. Here, we show that chromatin regulation plays a key role in activating MBF-dependent transcription. Gcn5, a part of the SAGA complex, ...
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#1Iva Knezevic (UPF: Pompeu Fabra University)H-Index: 1
#2Alberto González-Medina (UPF: Pompeu Fabra University)H-Index: 2
Last. José Ayté (UPF: Pompeu Fabra University)H-Index: 25
view all 5 authors...
This work was supported by grants from the Spanish Ministerio de Economia y Competitividad (BFU2015-66347-P), PLAN E and Feder, by MEIONet (BFU2015-71786-REDT) and by Unidad de Excelencia Maria de Maeztu (MDM-2014-0370). EH is recipient of an ICREA Academia Award (Generalitat de Catalunya)
2 CitationsSource
#1Alba Domènech (UPF: Pompeu Fabra University)H-Index: 5
#2José Ayté (UPF: Pompeu Fabra University)H-Index: 25
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 4 authors...
Background Hydrogen peroxide (H2O2) is generated as a by-product of metabolic reactions during oxygen use by aerobic organisms, and can be toxic or participate in signaling processes. Cells, therefore, need to be able to sense and respond to H2O2 in an appropriate manner. This is often accomplished through thiol switches: Cysteine residues in proteins that can act as sensors, and which are both scarce and finely tuned. Bacteria and eukaryotes use different types of such sensors—either a one-comp...
5 CitationsSource
#1Laura Sánchez-Mir (UPF: Pompeu Fabra University)H-Index: 6
#2Clàudia Salat-Canela (UPF: Pompeu Fabra University)H-Index: 2
Last. Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 34
view all 7 authors...
Stress-dependent activation of signaling cascades is often mediated by phosphorylation events, but the exact nature and role of these phosphorelays are frequently poorly understood. Here, we review which are the consequences of the stress-dependent phosphorylation of a transcription factor on gene activation. In fission yeast, the MAP kinase Sty1 is activated upon several environmental hazards and promotes cell adaptation and survival, greatly through activation of a gene program mediated by the...
5 CitationsSource
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