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Elena Hidalgo
Pompeu Fabra University
80Publications
33H-index
3,233Citations
Publications 83
Newest
#1Luis Marte (UPF: Pompeu Fabra University)
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last.Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
view all 6 authors...
Abstract Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s). In a screen to search for protein quality control components required for wild-type tolerance to oxidative stress in fission yeast, we have isolated eight gene deletions conferring resistance not only to H2O2 but also to caffeine. We show that dual resistance acquisition is totally or partially dependent on the t...
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Abstract Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic health. Reactive oxygen species (ROS) have emerged as intracellular messengers participating in bot...
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#1Mercè Carmona (UPF: Pompeu Fabra University)H-Index: 6
#2Laura de Cubas (UPF: Pompeu Fabra University)
Last.Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
view all 9 authors...
Genetically encoded probes monitoring H2O2 fluctuations in living organisms are key to decipher redox signaling events. Here we use a new probe, roGFP2-Tpx1.C169S, to monitor pre-toxic fluctuations of peroxides in fission yeast, where the concentrations linked to signaling or to toxicity have been established. This probe is able to detect nanomolar fluctuations of intracellular H2O2 caused by extracellular peroxides; expression of human aquaporin 8 channels H2O2 entry into fission yeast decreasi...
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#1Carlos Henríquez-Olguín (UCPH: University of Copenhagen)H-Index: 13
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last.Thomas E. Jensen (UCPH: University of Copenhagen)H-Index: 30
view all 6 authors...
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#1Alberto González-Medina (UPF: Pompeu Fabra University)H-Index: 2
#2Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
Last.José Ayté (UPF: Pompeu Fabra University)H-Index: 25
view all 3 authors...
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#1Alba Domènech (UPF: Pompeu Fabra University)H-Index: 5
#2José Ayté (UPF: Pompeu Fabra University)H-Index: 25
Last.Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
view all 4 authors...
Background Hydrogen peroxide (H2O2) is generated as a by-product of metabolic reactions during oxygen use by aerobic organisms, and can be toxic or participate in signaling processes. Cells, therefore, need to be able to sense and respond to H2O2 in an appropriate manner. This is often accomplished through thiol switches: Cysteine residues in proteins that can act as sensors, and which are both scarce and finely tuned. Bacteria and eukaryotes use different types of such sensors—either a one-comp...
3 CitationsSource
#1Iva Knezevic (UPF: Pompeu Fabra University)H-Index: 1
#2Alberto González-Medina (UPF: Pompeu Fabra University)H-Index: 2
Last.José Ayté (UPF: Pompeu Fabra University)H-Index: 25
view all 5 authors...
This work was supported by grants from the Spanish Ministerio de Economia y Competitividad (BFU2015-66347-P), PLAN E and Feder, by MEIONet (BFU2015-71786-REDT) and by Unidad de Excelencia Maria de Maeztu (MDM-2014-0370). EH is recipient of an ICREA Academia Award (Generalitat de Catalunya)
2 CitationsSource
#1Laura Sánchez-Mir (UPF: Pompeu Fabra University)H-Index: 5
#2Clàudia Salat-Canela (UPF: Pompeu Fabra University)H-Index: 2
Last.Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
view all 7 authors...
Stress-dependent activation of signaling cascades is often mediated by phosphorylation events, but the exact nature and role of these phosphorelays are frequently poorly understood. Here, we review which are the consequences of the stress-dependent phosphorylation of a transcription factor on gene activation. In fission yeast, the MAP kinase Sty1 is activated upon several environmental hazards and promotes cell adaptation and survival, greatly through activation of a gene program mediated by the...
4 CitationsSource
#1Miriam Sansó (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Daniel Pinto (McGill University)H-Index: 1
Last.Robert P. Fisher (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 36
view all 13 authors...
Cyclin-dependent kinase 9 (Cdk9) and histone H2B monoubiquitylation (H2Bub1) are both implicated in elongation by RNA polymerase II (RNAPII). In fission yeast, Cdk9 and H2Bub1 regulate each other through a feedback loop involving phosphorylation of the elongation factor Spt5. Conversely, genetic interactions suggest opposing functions of H2Bub1 and Cdk9 through an Spt5-independent pathway. To understand these interactions, we performed RNA-seq analysis after H2Bub1 loss, Cdk9 inhibition, or both...
1 CitationsSource
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