Chin Fei Chee
University of Malaya
Hydrogen bondOrganic chemistryChemistryBiochemistryStereochemistry
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Publications 45
#2Chin Fei CheeH-Index: 10
Last. Wen Siang TanH-Index: 23
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Nanoparticles (NPs) have emerged as a powerful drug-delivery tool for cancer therapies to enhance the specificity of drug actions, while reducing the systemic side effects. Nonetheless, NPs interact massively with the surrounding physiological environments including plasma proteins upon administration into the bloodstream. Consequently, they are rapidly cleared from the blood circulation by the mononuclear phagocyte system (MPS) or complement system, resulting in a premature elimination that wil...
#1Theebaa Anasamy (UM: University of Malaya)H-Index: 5
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract This study reports the in vivo performance of two tribenzyltin carboxylate complexes, tri(4-fluorobenzyl)tin[(N,N-diisopropylcarbamothioyl)sulfanyl]acetate (C1) and tribenzyltin isonicotinate (C9), in their native form as well as in a poly(lactic-co-glycolic acid) (PLGA)-based nanoformulation, to assess their potential to be translated into clinically useful agents. In a 4T1 murine metastatic mammary tumour model, single intravenous administration of C1 (2.7 mg/kg) and C9 (2.1 mg/kg; 2....
Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host immune systems, rendering these nanoparticles ineffective for drug delivery. The aim of this study was to reduce the antigenicity of hepatitis B core antigen (HBcAg) VLNPs by shiel...
#1Chan Kiang Lim (UTAR: Universiti Tunku Abdul Rahman)H-Index: 5
Last. Chin Fei Chee (International Medical University)H-Index: 10
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Phytochemical investigation on the dichloromethane stem bark extract of Calophyllum castaneum resulted in the isolation of five compounds, namely isoblancoic acid (1), blancoic acid (2), euxanthone (3), friedelin (4) and friedelinol (5). All these compounds were isolated for the first time from this plant. Their chemical structures were elucidated based on the spectroscopic analyses. The cytotoxicity of compounds 1-5 was assessed on a panel of cancer cell lines including bone (Saos-2, mg63), col...
#1Shameer Hisham (UM: University of Malaya)H-Index: 1
#2Hairul Anuar Tajuddin (UM: University of Malaya)H-Index: 5
Last. Zanariah Abdullah (UM: University of Malaya)H-Index: 8
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Abstract N-aryl-2-aminoquinolines have been widely synthesised and used in biological applications. However, their luminescence properties have not been studied in detail. Herein a series of N-aryl-2-aminoquinolines was synthesised from substitution reaction between 2-chloroquinoline and anilines with different substituent groups gave sufficient yield from 72–90%. The fluorescence behaviour was investigated in toluene, ethyl acetate and ethanol. The result shows that fluorescence quantum yield o...
4 CitationsSource
#1Hui Li Heng (UM: University of Malaya)H-Index: 1
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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1 CitationsSource
#1Ummi Husni Aminah Mohd Hazli (UM: University of Malaya)H-Index: 1
#2Azlina Abdul-Aziz (UM: University of Malaya)H-Index: 13
Last. Kin Weng Kong (UM: University of Malaya)H-Index: 14
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Abstract Alternanthera sessilis (red) (ASR) is an edible herbal plant with many beneficial health effects. This study aimed to investigate the antioxidant components and antioxidant activities of the edible leaves and stems of ASR extracted using solvent of varying polarities namely water, ethanol, ethyl acetate and hexane. ASR leaf extracts showed higher in both antioxidant components and activities than the stem extracts. Among the antioxidant components, the ethanol leaf extract showed higher...
1 CitationsSource
#1Amit R. Nath (UM: University of Malaya)H-Index: 2
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Noorsaadah Abd. Rahman (UM: University of Malaya)H-Index: 20
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Heterocycles are becoming ubiquitous in the modern chemistry nowadays. However, the synthesis of heterocycles remains challenging. Issues like simplicity, selectivity, environmental friendliness, and availability of starting materials are still key factors to be considered before planning for a synthesis. In the past three decades, the transition-metal-catalyzed cross-coupling and direct oxidative cross-coupling reactions have been commonly utilized for the construction of heterocycles. Although...
#1Nasser Alhajj (UiTM: Universiti Teknologi MARA)H-Index: 2
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Paolo ColomboH-Index: 47
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ABSTRACTIntroduction: Pulmonary drug delivery is organ-specific and benefits local drug action for lung cancer. The use of nanotechnology and targeting ligand enables cellular-specific drug action. Combination approaches increase therapeutic efficacy and reduce adverse effects of cancer chemotherapeutics that have narrow therapeutic index window and high cytotoxicity levels. The current progress of inhaled cancer chemotherapeutics has not been examined with respect to targeting strategy and clin...
3 CitationsSource
#1Shah Bakhtiar Nasir (UM: University of Malaya)H-Index: 2
#2Noorsaadah Abd. Rahman (UM: University of Malaya)H-Index: 20
Last. Chin Fei Chee (UM: University of Malaya)H-Index: 10
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2 CitationsSource