Eva C. Guinan
Harvard University
Publications 206
#1Matt S. Zinter (UCSF: University of California, San Francisco)H-Index: 8
#2Brent R. Logan (Center for International Blood and Marrow Transplant Research)H-Index: 49
Last.Christopher C. Dvorak (UCSF: University of California, San Francisco)H-Index: 30
view all 23 authors...
ABSTRACT Critically ill pediatric allogeneic hematopoietic cell transplant (HCT) patients may benefit from early and aggressive interventions aimed at reversing the progression of multiorgan dysfunction. Therefore, we evaluated 25 early risk-factors for PICU mortality in order to improve mortality prognostication. We merged the Virtual Pediatric Systems (VPS, LLC) and Center For International Blood and Marrow Transplant Research (CIBMTR) databases and analyzed 936 critically ill patients ≤21 yea...
#1Mitchell Sabloff (Ottawa Hospital Research Institute)H-Index: 21
#2Saurabh Chhabra (Center for International Blood and Marrow Transplant Research)H-Index: 10
Last.Alison W. Loren (UPenn: University of Pennsylvania)H-Index: 29
view all 34 authors...
Abstract Malignancy relapse is the most common cause of treatment failure among recipients of hematopoietic cell transplantation (HCT). Conditioning dose intensity can reduce disease relapse but is offset by toxicities. Improvements in radiotherapy techniques and supportive care may translate to better outcomes with higher irradiation doses in the modern era. This study compares outcomes of recipients of increasing doses of high-dose total body irradiation (TBI) divided into intermediate high do...
#1Raymond H. Mak (Brigham and Women's Hospital)H-Index: 32
#2Michael G. Endres (Harvard University)H-Index: 1
Last.Eva C. Guinan (Harvard University)H-Index: 43
view all 8 authors...
Importance Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial training and is subject to significant interobserver variation. Objective To determine whether crowd innovation could be used to rapidly produce artificial intelligence (AI) solutions that replicate the accuracy of an expert radiation oncol...
#1Qing-Shuo Zhang (OHSU: Oregon Health & Science University)H-Index: 10
#2Matthew Deater (OHSU: Oregon Health & Science University)H-Index: 4
Last.Markus Grompe (OHSU: Oregon Health & Science University)H-Index: 76
view all 7 authors...
#1Marsha A. Wilcox (Janssen Pharmaceutica)H-Index: 20
#2Adam Savitz (Janssen Pharmaceutica)H-Index: 10
Last.Joseph S. Ross (Yale University)H-Index: 52
view all 13 authors...
Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translational Science in Schizophrenia (OPTICS) Project was an open-science initiative aggregating Janssen clinical trial and NIH/NIMH data from real-world studies and trials in schizophrenia. The project aims were to show the value of using shared data to exam...
#1Pierre Azoulay (MIT: Massachusetts Institute of Technology)H-Index: 18
#2Joshua Graff-Zivin (UCSD: University of California, San Diego)H-Index: 5
Last.Eva C. Guinan (Harvard University)H-Index: 43
view all 13 authors...
Climb atop shoulders and wait for funerals. That, suggested Newton and then Planck, is how science advances (more or less). We9ve come far since then, but many notions about how people and practices, policies, and resources influence the course of science are still more rooted in traditions and intuitions than in evidence. We can and must do better, lest we resign ourselves to “intuition-based policy” when making decisions and investments aimed at driving scientific progress. Science invited exp...