Eva C. Guinan
Harvard University
ImmunologyHematopoietic stem cell transplantationTransplantationDiabetes mellitusMedicine
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Publications 229
#1Birgit Sawitzki (Charité)H-Index: 33
#2Paul Harden (University of Oxford)H-Index: 14
Last. William J. Burlingham (UW: University of Wisconsin-Madison)H-Index: 38
view all 61 authors...
Summary Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of regulatory CBMPs when combined with reduced immunosuppressive treatment. Methods The ONE Study consisted of seven investigator-led, single-arm trials done internationally at eight hospitals in France, Germany, Italy, the UK, and the USA (60 ...
3 CitationsSource
#1Matt S. Zinter (UCSF: University of California, San Francisco)H-Index: 9
#2Brent R. Logan (Center for International Blood and Marrow Transplant Research)H-Index: 51
Last. Christopher C. Dvorak (UCSF: University of California, San Francisco)H-Index: 34
view all 23 authors...
ABSTRACT Critically ill pediatric allogeneic hematopoietic cell transplant (HCT) patients may benefit from early and aggressive interventions aimed at reversing the progression of multiorgan dysfunction. Therefore, we evaluated 25 early risk-factors for PICU mortality in order to improve mortality prognostication. We merged the Virtual Pediatric Systems (VPS, LLC) and Center For International Blood and Marrow Transplant Research (CIBMTR) databases and analyzed 936 critically ill patients ≤21 yea...
1 CitationsSource
#1Eva C. Guinan (Harvard University)H-Index: 44
#1Jacqueline Ng Lane (Harvard University)H-Index: 2
Last. Karim R. Lakhani (Harvard University)H-Index: 27
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We consider how the cognitive similarity between knowledge-sharing partners affects the knowledge-production process, namely knowledge transfer, creation, and diffusion. We theorize that knowledge production is systematically shaped by the field and intellectual similarity between knowledge-sharing partners’ disciplines of study and domain area interests. To estimate relationships, we designed and executed a natural field experiment at a medical symposium, in which exogenous variation was introd...
#1Eva C. Guinan (Harvard University)H-Index: 44
#1Mitchell Sabloff (Ottawa Hospital Research Institute)H-Index: 22
#2Saurabh Chhabra (Center for International Blood and Marrow Transplant Research)H-Index: 14
Last. Alison W. Loren (UPenn: University of Pennsylvania)H-Index: 30
view all 34 authors...
Abstract Malignancy relapse is the most common cause of treatment failure among recipients of hematopoietic cell transplantation (HCT). Conditioning dose intensity can reduce disease relapse but is offset by toxicities. Improvements in radiotherapy techniques and supportive care may translate to better outcomes with higher irradiation doses in the modern era. This study compares outcomes of recipients of increasing doses of high-dose total body irradiation (TBI) divided into intermediate high do...
1 CitationsSource
#1Raymond H. Mak (Brigham and Women's Hospital)H-Index: 34
#2Michael G. Endres (Harvard University)H-Index: 12
Last. Eva C. Guinan (Harvard University)H-Index: 44
view all 8 authors...
Importance Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial training and is subject to significant interobserver variation. Objective To determine whether crowd innovation could be used to rapidly produce artificial intelligence (AI) solutions that replicate the accuracy of an expert radiation oncol...
12 CitationsSource
#1Misha TeplitskiyH-Index: 5
#2Hardeep RanuH-Index: 7
Last. Karim R. LakhaniH-Index: 27
view all 6 authors...
1 Citations
#1Christine M. Barbon (AstraZeneca)H-Index: 10
#2Kenneth J. Janec (Harvard University)H-Index: 1
Last. Eva C. Guinan (Harvard University)H-Index: 44
view all 5 authors...
: Alloantigen-specific hyporesponsiveness can be induced in alloreactive T cells contained within the whole peripheral blood mononuclear cell (PBMC) population by stimulating these responder cells ex vivo with HLA-mismatched stimulator PBMC as the antigen presenting cell (APC) source, in the presence of a CD28 costimulation blocking agent. As a result of this approach, specific alloreactivity is markedly decreased (by 1-2 logs), but third-party alloresponses and in vitro responses relying on the...
#1Qing-Shuo Zhang (OHSU: Oregon Health & Science University)H-Index: 10
#2Matthew Deater (OHSU: Oregon Health & Science University)H-Index: 4
Last. Markus Grompe (OHSU: Oregon Health & Science University)H-Index: 79
view all 7 authors...
BACKGROUND: Fanconi anemia is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Currently, no interventions to prevent or delay the formation of solid tumors are available. PROCEDURE: Two of the most important hallmarks of Fanconi anemia are inflammation and oxidative stress. In this study, we administrated the antioxidant atorvastatin and the anti-inflammatory drug celecoxib to cohorts of Fancd2-/- /Trp53+/- mice, a model of Fanconi anemia....
1 CitationsSource