Jiang He
Tulane University
Publications 734
#1Tamara Isakova (NU: Northwestern University)H-Index: 32
#2Xuan Cai (NU: Northwestern University)H-Index: 8
Last.Raymond R. TownsendH-Index: 63
view all 27 authors...
Rationale & Objective The pathogenesis of disordered mineral metabolism in chronic kidney disease (CKD) is largely informed by cross-sectional studies of humans and longitudinal animal studies. We sought to characterize the longitudinal evolution of disordered mineral metabolism during the course of CKD. Study Design Retrospective analysis nested in a cohort study. Setting & Participants Participants in the Chronic Renal Insufficiency Cohort (CRIC) Study who had up to 5 serial annual measurement...
#1Vladimir B. Seplyarskiy (Harvard University)H-Index: 10
#2Ruslan A. Soldatov (Harvard University)H-Index: 7
Last.Shamil R. Sunyaev (Brigham and Women's Hospital)H-Index: 67
view all 40 authors...
Mechanistic processes underlying human germline mutations remain largely unknown. Variation in mutation rate and spectra along the genome is informative about the biological mechanisms. We statistically decompose this variation into separate processes using a blind source separation technique. The analysis of a large-scale whole genome sequencing dataset (TOPMed) reveals nine processes that explain the variation in mutation properties between loci. Seven of these processes lend themselves to a b...
#1Zhengbao Zhu (Tulane University)H-Index: 2
#2Daoxia Guo (Soochow University (Taiwan))
Last.Jiang He (Tulane University)H-Index: 103
view all 13 authors...
Background Dickkopf-3 (Dkk-3) is implicated in the progression of atherosclerosis. This study aimed to investigate the association between serum Dkk-3 and the prognosis of ischemic stroke.
#1Chenhuan Zhang (Soochow University (Suzhou))
#2Sifan Qian (Soochow University (Suzhou))
Last.Tan Xu (Soochow University (Suzhou))H-Index: 14
view all 15 authors...
Abstract Background and aims Endostatin is implicated in the atherosclerosis process and serves as a promising cardiovascular biomarker, while its clinical significance in ischemic stroke patients remains unclear. We aimed to examine the association between endostatin and mortality and disability after ischemic stroke. Methods A total of 3463 acute ischemic stroke patients with measured plasma endostatin from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this study. ...
#1Daoxia Guo (Soochow University (Suzhou))H-Index: 2
#2Zhengbao Zhu (Soochow University (Suzhou))H-Index: 2
Last.Jiang He (Tulane University)H-Index: 103
view all 15 authors...
Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies. However, the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results. This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 mon...
#1Madeline H. Kowalski (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Huijun Qian (UNC: University of North Carolina at Chapel Hill)H-Index: 1
Last.Yun Li (UNC: University of North Carolina at Chapel Hill)H-Index: 74
view all 78 authors...
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more complex linkage disequilibrium structure. In order to better define the genetic architecture of these understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through the multi-ethnic NHLBI Tr...
1 CitationsSource
#1Yinkun Yan (Tulane University)H-Index: 1
#2Shengxu Li (Children's Hospitals and Clinics of Minnesota)H-Index: 31
Last.Wei-Min Chen (Tulane University)H-Index: 100
view all 7 authors...
Background Inflammation and insulin resistance play crucial roles in the development of type 2 diabetes mellitus (T2DM). We aim to examine the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and insulin resistance in non-diabetic adults and their joint effect on the development of hyperglycemia.
#1Daniel Edmonston (Duke University)H-Index: 1
#2Daniel Wojdyla (Duke University)H-Index: 40
Last.Alan S. Go (KP: Kaiser Permanente)H-Index: 87
view all 20 authors...
Rationale & Objective An elevated fibroblast growth factor 23 (FGF-23) level is independently associated with adverse outcomes in populations with chronic kidney disease, but it is unknown whether FGF-23 testing can improve clinical risk prediction in individuals. Study Design Prospective cohort study. Setting & Participants Participants in the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,789). Exposure Baseline carboxy-terminal FGF-23 (cFGF-23) level. Outcomes All-cause and cardiovasc...
#1Priyadarshini Kachroo (Brigham and Women's Hospital)H-Index: 4
#2Julian Hecker (Harvard University)H-Index: 2
Last.Sebastian ZoellnerH-Index: 3
view all 351 authors...
ABSTRACT Background Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based ‘Genetic Epidemiology of Asthma in Costa Rica’ study. Asthma affection ...