Joseph C. Wu
Stanford University
Publications 797
#1Eric J. Kort (Van Andel Institute)H-Index: 23
#2Nazish SayedH-Index: 14
Last.Stefan JovingeH-Index: 26
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The cost of drug development from initial concept to FDA approval has been estimated to be about 2.6 billion USD. This cost precludes development of targeted therapies for rare diseases such as monogenetic cardiomyopathies. As part of the Library of Integrated Network-based Cellular Signatures (LINCS) program funded by the NIH, the Broad Institute of MIT has publicly released transcriptional profiles quantifying the effects of more than 25,000 perturbagens on the expression of 978 genes in up to...
#1Mohammad Javad Hajipour (MSU: Michigan State University)
#2Mehdi Mehrani (Tehran University of Medical Sciences)H-Index: 1
Last.Haniyeh Aghaverdi (Brigham and Women's Hospital)H-Index: 5
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The adult myocardium has a limited regenerative capacity following heart injury, and the lost cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical therapies to resurrect the infarcted heart results in injured heart enlargement and remodeling to maintain its physiological functions. These remodeling processes ultimately leads to ischemic cardiomyopathy and heart failure (HF). Recent therapeutic approaches (e.g., regenerative and nanomedicine) have shown ...
#1Chengyi Tu (Cardiovascular Institute of the South)H-Index: 3
#2Racheal Mezynski (Cardiovascular Institute of the South)
Last.Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 87
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#1Divya C. Kernik (UC Davis: University of California, Davis)
#2Stefano Morotti (UC Davis: University of California, Davis)H-Index: 10
Last.Colleen E. Clancy (UC Davis: University of California, Davis)H-Index: 29
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#1Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 87
#2Priyanka Garg (Cardiovascular Institute of the South)H-Index: 5
Last.Peter J. SchwartzH-Index: 125
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Long-QT syndrome, a frequently fatal inherited arrhythmia syndrome caused by genetic variants (congenital) or drugs (acquired), affects 1 in 2000 people worldwide. Its sentinel event is often sudde...
#1Ksenia Blinova (CDRH: Center for Devices and Radiological Health)H-Index: 11
#2Derek Schocken (CDRH: Center for Devices and Radiological Health)H-Index: 1
Last.David G. Strauss (CDER: Center for Drug Evaluation and Research)H-Index: 26
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#1Hao Zhang (Stanford University)
#2Lei Tian (Stanford University)H-Index: 2
Last.Joseph C. Wu (Stanford University)H-Index: 87
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Rationale: Activated fibroblasts are the major cell type that secrete excessive extracellular matrix in response to injury, contributing to pathological fibrosis and leading to organ failure. Effec...
#1Leili Rohani (U of C: University of Calgary)H-Index: 2
#2Pranav Machiraju (U of C: University of Calgary)H-Index: 1
Last.Aneal Khan (U of C: University of Calgary)H-Index: 13
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Background: The dilated cardiomyopathy with ataxia syndrome (DCMA) is an understudied autosomal recessive disease caused by loss-of-function mutations in the poorly characterized gene DNAJC19. Clinically, DCMA is commonly associated with heart failure and early death in affected children through an unknown mechanism. DCMA has been linked to Barth syndrome, a rare but well-studied disorder caused by deficient maturation of cardiolipin (CL), a key mitochondrial membrane phospholipid. Methods: Peri...