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Joseph C. Wu
Stanford University
835Publications
91H-index
30.1kCitations
Publications 836
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Abstract Microfluidic technologies offer new platforms for biosensing in various clinical and point-of-care (POC) applications. Currently, at the clinical settings, the gold standard diagnostic platforms for multiplexed sensing are multi-step, time consuming, requiring expensive and bulky instruments with a constant need of electricity which makes them unsuitable for resource-limited or POC settings. These technologies are often limited by logistics, costly assays and regular maintenance. Althou...
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Matrix nanotopographical cues are known to regulate the structure and function of somatic cells derived from human pluripotent stem cell (hPSC) sources. High-throughput electrophysiological analysis of excitable cells derived from hPSCs is possible via multielectrode arrays (MEAs), but conventional MEA platforms use flat substrates and do not reproduce physiologically-relevant tissue-specific architecture. To address this issue, we developed a high-throughput nanotopographically-patterned multie...
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#1John F. Gottlieb (NU: Northwestern University)H-Index: 3
#2Francesco BenedettiH-Index: 47
Last.Shenghao Chen (NU: Northwestern University)
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Summary The protein-level translational status and function of many alternative splicing events remain poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to identify protein alternative splicing isoforms in the human proteome by constructing tissue-specific protein databases that prioritize transcript splice junction pairs with high translational potential. Using the custom databases to reanalyze ∼80 million mass spectra in public proteomics datasets, we identify more...
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Summary With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study the effects of microgravity on cell-level cardiac function and gene expression. The hiPSC-CMs were cultured aboard the ISS for 5.5 weeks and their gene expression, structure, and functions were compared with ground control hiPS...
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While many diseases of aging have been linked to the immunological system, immune metrics with which to identify the most at-risk individuals are lacking. Here, we studied the blood immunome of 1001 individuals age 8-96 and derived an inflammatory clock of aging (iAge), which tracked with multi-morbidity and immunosenescence. In centenarians, iAge was on average, 40 years lower than their corresponding chronological age. The strongest contributor to this metric was the chemokine CXCL9, which was...
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#1Lin Wang (Stanford University)
#2Mark D. Pegram (Stanford University)H-Index: 51
Last.Joseph C. Wu (Stanford University)H-Index: 91
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ABSTRACTIntroduction: Although many current cancer therapies are effective, the mortality rate globally is unacceptably high. Cancer remains the second leading cause of death worldwide after heart ...
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#1Dietmar Winkler (Medical University of Vienna)H-Index: 20
#2Marie Spies (Medical University of Vienna)H-Index: 13
Last.Edda Pjrek (Medical University of Vienna)H-Index: 14
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ABSTRACTObjective: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is used most often for depression. The aim of this study was to examine the pattern of use of SD in psyc...
2 CitationsSource
#1G. A. GintantH-Index: 7
#2Paul W. BurridgeH-Index: 25
Last.Joseph C. WuH-Index: 91
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It is now well recognized that many lifesaving oncology drugs may adversely affect the heart and cardiovascular system, including causing irreversible cardiac injury that can result in reduced qual...
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