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Jyotsna Batra
Queensland University of Technology
Genome-wide association studySingle-nucleotide polymorphismProstate cancerGeneticsBiology
155Publications
26H-index
3,208Citations
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Publications 163
Newest
#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 11
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 4
Last. Henrik Grönberg (KI: Karolinska Institutet)H-Index: 72
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We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated...
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#1Thomas KryzaH-Index: 5
#2BockNathalie (QUT: Queensland University of Technology)H-Index: 8
Last. Judith A. Clements (QUT: Queensland University of Technology)H-Index: 54
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Kallikrein‐related peptidase 14 (KLK14) is one of several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development. However, the modulation of KLK14 expression during PCa progression and the molecular and biological functions of this protease in the prostate tumour microenvironment remain unknown. To determine the modulation of KLK14 expression during PCa progression, ...
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 12
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
Last. Sara Lindstroem (UW: University of Washington)H-Index: 46
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#1Adil Malik (QUT: Queensland University of Technology)H-Index: 1
#2Srilakshmi Srinivasan (QUT: Queensland University of Technology)H-Index: 9
Last. Jyotsna Batra (QUT: Queensland University of Technology)H-Index: 26
view all 3 authors...
Prostate Cancer is the second most common male cancer affecting Western society. Despite substantial advances in the exploration of Prostate Cancer biomarkers and treatment strategies, men are over diagnosed with inert Prostate Cancer, while there is also a substantial mortality from the invasive disease. Precision medicine is the management of treatment profiles across different cancers predicting therapies for individual cancer patients. Strategies including individual genomic profiling and ta...
1 CitationsSource
#1Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 4
#2Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 1
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Background: Prostate cancer causes substantial morbidity and mortality worldwide. Recently, a polygenic hazard score (PHS1)--the weighted sum of 54 single-nucleotide polymorphism (SNP) genotypes--was developed and validated to predict age of aggressive prostate cancer onset in Caucasians. We evaluated the performance of the PHS for prediction of aggressive prostate cancer and of death from prostate cancer across diverse ethnic populations. Methods: 80,491 men of various self-reported race/ethnic...
1 CitationsSource
#1Chamikara Liyanage (QUT: Queensland University of Technology)H-Index: 1
#2Achala Fernando (QUT: Queensland University of Technology)H-Index: 1
Last. Jyotsna Batra (QUT: Queensland University of Technology)H-Index: 26
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Alternative splicing of precursor mRNA is a key mediator of gene expression regulation leading to greater diversity of the proteome in complex organisms. Systematic sequencing of the human genome and transcriptome has led to our understanding of how alternative splicing of critical genes leads to multiple pathological conditions such as cancer. For many years, proteases were known only for their roles as proteolytic enzymes, acting to regulate/process proteins associated with diverse cellular fu...
1 CitationsSource
#1Afshin Moradi (QUT: Queensland University of Technology)
#2Srilakshmi Srinivasan (QUT: Queensland University of Technology)H-Index: 9
Last. Jyotsna Batra (QUT: Queensland University of Technology)H-Index: 26
view all 4 authors...
The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has been suggested as a molecu...
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#2Thomas KryzaH-Index: 5
Last. Jyotsna BatraH-Index: 26
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#1Xia JiangH-Index: 6
#1Xia JiangH-Index: 12
Last. Sara LindstroemH-Index: 46
view all 333 authors...
textabstractAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 12
Last. Sara Lindstroem (UW: University of Washington)H-Index: 46
view all 333 authors...
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