Melanie J. Davies
Leicester General Hospital
EndocrinologyPhysical therapyType 2 diabetesDiabetes mellitusMedicine
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Publications 776
PURPOSE: This study aimed to investigate whether prospectively reallocating time away from sedentary behavior (SB) into different physical activity intensities is associated with 12-month change to cardiometabolic health in a cohort at high risk of type 2 diabetes (T2DM). METHODS: Participants with known risk factors for T2DM were recruited from primary care (Leicestershire, United Kingdom) as part of the Walking Away from Type 2 Diabetes trial (n = 808). Participants were followed up at 12, 24,...
Abstract In this paper, a new algorithm denoted as FilterK is proposed for improving the purity of k-means derived physical activity clusters by reducing outlier influence. We applied it to physical activity data obtained with body-worn accelerometers and clustered using k-means. We compared its performance with three existing outlier detection methods: Local Outlier Factor, Isolation Forests and KNN using the ground truth (class labels), average cluster and event purity (ACEP). FilterK provided...
#1Michelle Hadjiconstantinou (University of Leicester)H-Index: 4
#2Alison J. Dunkley (University of Leicester)H-Index: 9
Last. Melanie J. Davies (University of Leicester)H-Index: 82
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Background Type 2 diabetes mellitus (T2DM) is a demanding condition that impacts the person living with the condition physically and psychologically. Promoting emotional support is a key strategy to improve diabetes care. Aim To explore the views and experiences of people with T2DM and healthcare professionals (HCPs) on emotional support in diabetes care, and identify barriers and facilitators to the provision of emotional support in clinical practice. Design & setting A qualitative study in Eng...
#1Lisa Huddlestone (University of Leicester)
#2Jessica Turner (DMU: De Montfort University)
Last. Graham D. Martin (University of Cambridge)H-Index: 14
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BACKGROUND: Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have examined the application of NPT across international healthcare and reports its benefits. However, given the distinctive clinical function, organisational arrangements and the increasing management of people with a wide variety of conditions in primary care settings in the United Kingdom...
#1Francesco ZaccardiH-Index: 24
#2Melanie J. DaviesH-Index: 82
Last. Kamlesh KhuntiH-Index: 4
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The last decade has witnessed an exponential growth in the opportunities to collect and link health-related data from multiple resources, including primary care, administrative, and device data. The availability of these “real-world”, “big data” has fuelled also an intense methodological research into methods to handle them and extract actionable information. In medicine, the evidence generated from “real-world data” (RWD), which are not purposely collected to answer biomedical questions, is com...
#1David R. Webb (Leicester General Hospital)H-Index: 23
#2Zin Zin Htike (Leicester General Hospital)
Last. Gerry P. McCann (University of Leicester)H-Index: 23
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Drugs targeting the incretin pathway have unexplained important actions on the cardiovascular system. The aim of this study was to compare the effects of a GLP-1 receptor analogue and a DPP-4 inhibitor on MRI derived measures of cardiovascular function. MATERIALS AND METHODS: In a prospective, randomised, open-label, blinded end-point trial liraglutide (1.8 mg) and sitagliptin (100 mg) were compared in asymptomatic, non-insulin treated young (18-50 years) adults with obesity and type 2 diabetes....
#1A.K. Woolley (Leicester General Hospital)
#2Yogini V. Chudasama (Leicester General Hospital)H-Index: 4
Last. Kamlesh Khunti (Leicester General Hospital)H-Index: 66
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AIM: To examine the influence of sociodemographic factors of interest on preference for a particular health education format among people with type 2 diabetes and/or cardiovascular disease. METHODS: A questionnaire was used to collect information on the influence of six sociodemographic factors of interest on the preference for health education formats in people with type 2 diabetes and/or cardiovascular disease. Chi-squared tests were used to examine the distribution of preferences between grou...
#1Claire A. LawsonH-Index: 4
#2Francesco ZaccardiH-Index: 24
Last. Umesh T. KadamH-Index: 17
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Background: There are multiple risk factors for heart failure, but contemporary temporal trends according to sex, socioeconomic status, and ethnicity are unknown. Methods: Using a national UK gener...
#1E. L. Baldry (University Hospitals of Leicester NHS Trust)
#1Emma Baldry (University of Leicester)
Last. D. R. Webb (University Hospitals of Leicester NHS Trust)
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#1Humaira Hussein (University of Leicester)H-Index: 1
#2Francesco Zaccardi (University of Leicester)H-Index: 24
Last. Laura J. Gray (University of Leicester)H-Index: 63
view all 9 authors...
AIM: To compare the efficacy and tolerability of sodium-glucose co-transporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in adults with type 2 diabetes. MATERIALS AND METHODS: Electronic databases were searched from inception to 24 April 2019 for randomized controlled trials reporting change in glycated haemoglobin (HbA1c) at approximately 24 and/or 52 weeks for SGLT-2is and/or GLP-1RAs (classified as short- and long-acting). Bayesian network meta-analyses ...