Hermann Brenner
German Cancer Research Center
EpidemiologyCancerPopulationColorectal cancerMedicine
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Publications 1871
#1Lina Jansen (DKFZ: German Cancer Research Center)H-Index: 26
#2Chloé Charlotte Schröder (DKFZ: German Cancer Research Center)H-Index: 1
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
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Cancer registration plays a key role in monitoring the burden of cancer. However, cancer registry (CR) data are usually made available with substantial delay to ensure best possible completeness of case ascertainment. Here, we investigate empirically with routinely available data whether such a delay is mandatory for survival analyses or whether data can be used earlier to provide more up-to-date survival estimates. We compared distributions of prognostic factors and period relative survival est...
#1Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
#2Bernd HolleczekH-Index: 33
Last. Ben SchoettkerH-Index: 1
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#1Haixin Yu (DKFZ: German Cancer Research Center)H-Index: 1
#2Janhavi R. Raut (DKFZ: German Cancer Research Center)
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
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Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional consideration of genetic risk scores (GRSs) and epigenetic risk scores defined by DNA methylation. We conducted a nested case-control study of 143 incident LC cases and 1460 LC-free controls within a prospective cohort of 9949 participants aged 50–75 years with 14-year follow-up. Lifetime smoking hi...
#1Amelie Echle (RWTH Aachen University)H-Index: 1
#2Heike I. Grabsch (UM: Maastricht University)H-Index: 34
Last. Jeremias Krause (RWTH Aachen University)H-Index: 1
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Abstract Background and Aims Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR) in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI and dMMR in tumor samples on routine histology slides faster and cheaper than molecular assays. But clinical application of this technology requires high performance and multisite validation, which have not yet been performed. Methods We collected hematoxylin and eosin-stained slides, and findings from mol...
#1Jingjing Liu (EUR: Erasmus University Rotterdam)H-Index: 2
#2Wendy J. C. Prager-van der Smissen (EUR: Erasmus University Rotterdam)H-Index: 5
Last. Christine B. Ambrosone (Roswell Park Cancer Institute)H-Index: 65
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In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E ...
#1Anne J.M.R. Geijsen (WUR: Wageningen University and Research Centre)H-Index: 2
#2Eline H. van Roekel (UM: Maastricht University)H-Index: 5
Last. Dieuwertje E. Kok (WUR: Wageningen University and Research Centre)H-Index: 10
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Colorectal cancer is the second most common cause of cancer-related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of 130 metabolites among 744 Stages I–IV colorectal cancer patients from ongoing cohort studies. Plasma samples, collected at diagnosis, were analyzed wi...
1 CitationsSource
#1Jiantao Ma (NIH: National Institutes of Health)H-Index: 12
#2Casey M. Rebholz (Johns Hopkins University)H-Index: 18
Last. Michael M. Mendelson (NIH: National Institutes of Health)H-Index: 14
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Background - DNA methylation patterns associated with habitual diet have not been well studied. Methods - Diet quality was characterized using a Mediterranean-style diet score (MDS) and the Alternative Healthy Eating Index score (AHEI). We conducted ethnicity-specific and trans-ethnic epigenome-wide association analyses for diet quality and leukocyte-derived DNA methylation at over 400,000 cytosine-guanine dinucleotides (CpGs) in five population-based cohorts including 6,662 European ancestry (E...
#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 11
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 4
Last. Henrik Grönberg (KI: Karolinska Institutet)H-Index: 72
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We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated...
#1Yan Zhang (DKFZ: German Cancer Research Center)H-Index: 29
#2Melanie Bewerunge-Hudler (DKFZ: German Cancer Research Center)H-Index: 14
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 7 authors...
Evidence has shown that certain methylation markers derived from blood can mirror corresponding methylation signatures in internal tissues. In the current study we aimed to investigate two strong epigenetic predictors for lifespan, derived from blood DNA methylation data, in tissue samples of solid cancer patients. Using data from the Cancer Genome Atlas (TCGA) and the German DACHS study, we compared a mortality risk score (MRscore) and DNAmphenoAge in paired tumor and adjacent normal tissue sam...