Hermann Brenner
German Cancer Research Center
Publications 1733
#1Lei Huang (DKFZ: German Cancer Research Center)H-Index: 2
#2Yesilda Balavarca (DKFZ: German Cancer Research Center)H-Index: 7
Last.Lina Jansen (DKFZ: German Cancer Research Center)H-Index: 26
view all 15 authors...
Background Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I–II PaC receiving chemotherapy and at developing and internationally validating a survival-predicting model.
#1Alexander TeumerH-Index: 70
#2Yong Li (University of Freiburg)H-Index: 26
Last.Anna Köttgen (Johns Hopkins University)H-Index: 52
view all 186 authors...
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an ind...
#1Xīn Gào (DKFZ: German Cancer Research Center)H-Index: 9
#2Yan Zhang (DKFZ: German Cancer Research Center)H-Index: 29
Last.Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
view all 7 authors...
Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data (2000–2016). Blood DNA methylation in promoter regions of 519 genes, known to be involved in pathways from oxidative stress (OS) to...
#1Marco Matejcic (SC: University of Southern California)H-Index: 1
#2Ed Saunders (ICR: Institute of Cancer Research)H-Index: 23
Last.Christopher A. Haiman (SC: University of Southern California)H-Index: 82
view all 77 authors...
Correction to: Nature Communications;, published online 5 November 2018. The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
#1Nicholas Mancuso (UCLA: University of California, Los Angeles)H-Index: 13
#2Simon A. Gayther (Cedars-Sinai Medical Center)H-Index: 63
Last.Esther M. John (Stanford University)H-Index: 75
view all 50 authors...
The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, In the original HTML version of this Article, the order of authors within the author list was incorrect. The consortium PRACTICAL consortium was incorrectly listed after Bogdan Pasaniuc and should have been listed aft...
#1Philip J. Law (ICR: Institute of Cancer Research)H-Index: 12
#2Maria Timofeeva (Medical Research Council)H-Index: 10
Last.Malcolm G. Dunlop (Medical Research Council)H-Index: 66
view all 98 authors...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
#1Min Jia (DKFZ: German Cancer Research Center)H-Index: 5
#2Yan Zhang (DKFZ: German Cancer Research Center)H-Index: 29
Last.Michael Hoffmeister (DKFZ: German Cancer Research Center)H-Index: 43
view all 17 authors...
Results of previous studies on the association of the CpG island methylator phenotype (CIMP) with colorectal cancer (CRC) prognosis were inconsistent and mostly based on different CIMP definitions. The current study aimed to comprehensively investigate the associations between DNA methylation on genes previously used to define CIMP status with CRC survival. Patients with CRC followed up for a median of 5.2 years were divided into a study cohort (n = 568) and a validation cohort (n = 308). DNA me...
#1B. Holleczek (DKFZ: German Cancer Research Center)H-Index: 14
#2Christa StegmaierH-Index: 48
Last.Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 5 authors...
Population-based estimates of the long-term risk of loco-regional recurrence and distant metastases of breast cancer (BRC) patients are scant, as most published studies used hospital-based cohorts or participants of clinical trials. This work aims to extend available knowledge by providing population-based long-term estimates of the cumulative risk of BRC recurrence up to 10 years after diagnosis. Data from the population-based Saarland Cancer Registry were used and included 9359 female patients...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
view all 333 authors...