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Fabricio F. Costa
Northwestern University
CancermicroRNADNA methylationCancer researchBiology
69Publications
24H-index
1,955Citations
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Publications 69
Newest
#1Michel L. LeiteH-Index: 1
#2Elio F. Vanin (Epigenomics AG)H-Index: 10
Last. Fabricio F. CostaH-Index: 24
view all 6 authors...
Abstract Ependymoma, a rare pediatric tumor originating from ependymal cells located in the lining of ventricular surfaces in the brain, presents great challenges in treatment despite advances in neurosurgical techniques. In order to identify new molecular biomarkers that could improve clinical management and outcomes, we have used RNA-seq to profile the Whole Transcriptome of three ependymoma samples and one normal control brain tissue, producing a total of 2.5 Gigabases of sequencing data. Dif...
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#1André Moraes Nicola (UnB: University of Brasília)H-Index: 17
#2Patrícia Albuquerque (UnB: University of Brasília)H-Index: 12
Last. Maria Sueli Soares Felipe (UCB: Universidade Católica de Brasília)H-Index: 29
view all 9 authors...
Abstract The need for better antifungal therapy is commonly accepted in view of the high mortality rates associated with systemic infections, the low number of available antifungal classes, their associated toxicity and the increasing number of infections caused by strains with natural or acquired resistance. The urgency to expand the range of therapeutic options for the treatment of fungal infections has led researchers in recent decades to seek alternative antifungal targets when compared to t...
10 CitationsSource
#1Michel L. Leite (UCB: Universidade Católica de Brasília)H-Index: 1
#2Kamila B.O. Sampaio (UCB: Universidade Católica de Brasília)H-Index: 1
Last. Nicolau B. da Cunha (UCB: Universidade Católica de Brasília)H-Index: 3
view all 6 authors...
1 CitationsSource
#1Liliane M. B. Klassen (UFPR: Federal University of Paraná)H-Index: 4
#2Andressa Chequin (UFPR: Federal University of Paraná)H-Index: 3
Last. Giseli Klassen (UFPR: Federal University of Paraná)H-Index: 12
view all 11 authors...
Abstract Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Metastasis remains a major challenge for the clinical management and prognosis of patients with cancer. The metalloprotease MMP-9 plays a critical role in the first step of metastasis through extracellular matrix degradation. In this study, our goal was to determine the effect of epigenetic mechanisms in the promoter and intragenic region of this gene and to correlate it to...
6 CitationsSource
#1Robert PogueH-Index: 6
Last. Fabricio F. CostaH-Index: 24
view all 7 authors...
Rare genetic diseases collectively impact a significant portion of the world’s population. For many diseases there is limited information available, and clinicians can find difficulty in differentiating between clinically similar conditions. This leads to problems in genetic counseling and patient treatment. The biomedical market is affected because pharmaceutical and biotechnology industries do not see advantages in addressing rare disease treatments, or because the cost of the treatments is to...
6 CitationsSource
#1Michel L. Leite (UCB: Universidade Católica de Brasília)H-Index: 1
#2Fabricio F. CostaH-Index: 24
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#1Michel L. LeiteH-Index: 1
#2Fabricio F. CostaH-Index: 24
Source
Abstract Despite the advances in tumor identification and treatment, cancer remains the primary driver of death around the world. Also, regular treatments for the disease are incapable of targeting particular cancer types at different stages since they are not specifically focused on harmful cells since they influence both solid and tumor cells, causing side effects and undesirable symptoms. Therefore, novel strategies should be developed to treat this disease. Several efforts have been made in ...
10 CitationsSource
Last. Giseli KlassenH-Index: 12
view all 15 authors...
4 CitationsSource
#1Jun Wang (NU: Northwestern University)H-Index: 14
#2Ali Shidfar (NU: Northwestern University)H-Index: 4
Last. Seema Ahsan Khan (NU: Northwestern University)H-Index: 27
view all 9 authors...
Purpose: miRNAs are non-coding RNAs that are abnormally expressed in breast cancer, with critical roles in cancer due to their regulation of large gene networks. miRNA expression in benign high-risk breast tissue has never been evaluated, but it may provide information about early dysregulation events that contribute to breast cancer risk. The contralateral unaffected breast (CUB) of women with unilateral breast cancer is in high-risk for the second primary cancer. Thus, we examined miRNA expres...
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