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H. Marshall
Whitman College
7Publications
1H-index
19Citations
Publications 7
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#1H. Marshall (Whitman College)H-Index: 1
#2M. Venkat (Whitman College)H-Index: 1
Last.Douglas H. Juers (Whitman College)H-Index: 17
view all 5 authors...
Both crystallization and cryoprotection are often bottlenecks for high-resolution X-ray structure determination of macromolecules. Methylamine osmolytes are known stabilizers of protein structure. One such osmolyte, trimethylamine N-oxide (TMAO), has seen occasional use as an additive to improve macromolecular crystal quality and has recently been shown to be an effective cryoprotective agent for low-temperature data collection. Here, TMAO and the related osmolytes sarcosine and betaine are inve...
19 CitationsSource
#1J.K.B. CahnH-Index: 11
#2M. VenkatH-Index: 1
Last.Douglas H. JuersH-Index: 17
view all 4 authors...
Source
#1J.K.B. CahnH-Index: 11
#2M. VenkatH-Index: 1
Last.Douglas H. JuersH-Index: 17
view all 4 authors...
Source
#1J.K.B. CahnH-Index: 11
#2M. VenkatH-Index: 1
Last.Douglas H. JuersH-Index: 17
view all 4 authors...
Source
#1J.K.B. CahnH-Index: 11
#2M. VenkatH-Index: 1
Last.Douglas H. JuersH-Index: 17
view all 4 authors...
Source
#1Douglas H. JuersH-Index: 17
#2H. MarshallH-Index: 1
Last.M. VenkatH-Index: 1
view all 3 authors...
Osmolytes, organic compounds used by organisms to maintain osmotic balance, are known to modulate the solution behavior of proteins, in some cases increasing stability. Due to the nature of protein crystallization and the need for stable proteins to produce crystals, osmolytes could prove to be useful agents for crystallization. In this study, we demonstrate the potential of trimethylamine N-oxide (TMAO), a common osmolyte, as the primary precipitating agent for protein crystallization. TMAO was...
Source
#1H. MarshallH-Index: 1
#2M. VenkatH-Index: 1
Last.Douglas H. JuersH-Index: 17
view all 3 authors...
1