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Polly A. Hansen
Medical College of Wisconsin
EndocrinologyGlucose transporterInsulinDiabetes mellitusBiology
60Publications
33H-index
3,286Citations
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Publications 59
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#1Matthew Waas (MCW: Medical College of Wisconsin)H-Index: 5
#2Shana T. Snarrenberg (MCW: Medical College of Wisconsin)H-Index: 1
Last. Rebekah L. Gundry (MCW: Medical College of Wisconsin)H-Index: 17
view all 7 authors...
MOTIVATION: Cell-type specific surface proteins can be exploited as valuable markers for a range of applications including immunophenotyping live cells, targeted drug delivery, and in vivo imaging. Despite their utility and relevance, the unique combination of molecules present at the cell surface are not yet described for most cell types. A significant challenge in analyzing 'omic' discovery datasets is the selection of candidate markers that are most applicable for downstream applications. RES...
3 CitationsSource
#1Matthew Waas (MCW: Medical College of Wisconsin)H-Index: 5
#2Shana T. Snarrenberg (MCW: Medical College of Wisconsin)H-Index: 1
Last. Rebekah L. Gundry (MCW: Medical College of Wisconsin)H-Index: 17
view all 7 authors...
Cell surface proteins play critical roles in a wide range of biological functions and disease processes through mediation of adhesion and signaling between a cell and its environment. Owing to their biological significance and accessibility, cell surface proteomes (i.e. surfaceomes) are a rich source of targets for developing tools and strategies to identify, study, and manipulate specific cell types of interest, from immunophenotyping and immunotherapy to targeted drug delivery and in vivo imag...
1 CitationsSource
#1Hong He (MCW: Medical College of Wisconsin)H-Index: 3
#2Katie Holl (MCW: Medical College of Wisconsin)H-Index: 7
Last. Leah C. Solberg Woods (Wake Forest University)H-Index: 14
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Type 2 diabetes is a complex disorder affected by multiple genes and the environment. Our laboratory has shown that in response to a glucose challenge, two-pore channel 2 (Tpcn2) knockout mice exhi...
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#1Aaron C. BaldwinH-Index: 5
#2Aaron NaatzH-Index: 5
Last. John A. CorbettH-Index: 57
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: Palmitate attenuates insulin secretion and reduces the viability of insulin-producing cells. Previous studies identified the aberrant palmitoylation or mispalmitoylation of proteins as one mechanism by which palmitate causes β-cell damage. In this report, we identify a role for lysosomal protein degradation as a mechanism by which β cells defend themselves against excess palmitate. The cation-independent mannose 6-phosphate receptor (CI-MPR) is responsible for the trafficking of mannose 6-phos...
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#1Robert C. HicknerH-Index: 39
#2John O. HolloszyH-Index: 114
Last. Edward O. OjukaH-Index: 12
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#1John O. HolloszyH-Index: 114
#2Jonathan S. FisherH-Index: 11
Last. Tobias NygaardH-Index: 5
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#2Polly A. HansenH-Index: 33
#3Lorraine A. NolteH-Index: 31
Last. Ian R. W. RitchieH-Index: 8
view all 13 authors...
#1Polly A. HansenH-Index: 33
#2Lorraine A. NolteH-Index: 31
Last. Jennifer S. McCartneyH-Index: 9
view all 16 authors...
#1Lindsey E. Padgett (UAB: University of Alabama at Birmingham)H-Index: 7
#2Katarzyna A. Broniowska (MCW: Medical College of Wisconsin)H-Index: 18
Last. Hubert M. Tse (UAB: University of Alabama at Birmingham)H-Index: 23
view all 5 authors...
Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or prevents disease, respectively. CD4+ and CD8+ T cells use distinct effector mechanisms and act at different stages throughout T1D to fuel pancreatic β-cell destruction and disease ...
159 CitationsSource
#2John O. HolloszyH-Index: 114
Last. Helen H. HostH-Index: 10
view all 7 authors...
You might find this additional info useful...This article cites€25 articles, 17 of which you can access for free at: http://jap.physiology.org/content/82/2/711.full#ref-list-1This article has been cited by€21 other HighWire-hosted articles: http://jap.physiology.org/content/82/2/711#cited-by Updated information and services including high resolution figures, can be found at: http://jap.physiology.org/content/82/2/711.fullAdditional material and information about Journal of Applied Physiology can...
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