Polly A. Hansen
Medical College of Wisconsin
Publications 55
#1Matthew Waas (MCW: Medical College of Wisconsin)H-Index: 4
#2Shana T. Snarrenberg (MCW: Medical College of Wisconsin)
Last.Rebekah L. Gundry (MCW: Medical College of Wisconsin)H-Index: 16
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Cell surface proteins play critical roles in a wide range of biological functions and disease processes through mediation of adhesion and signaling between a cell and its environment. Owing to their biological significance and accessibility, cell surface proteomes (i.e. surfaceomes) are a rich source of targets for developing tools and strategies to identify, study, and manipulate specific cell types of interest, from immunophenotyping and immunotherapy to targeted drug delivery and in vivo imag...
#1Hong He (MCW: Medical College of Wisconsin)H-Index: 2
#2Katie Holl (MCW: Medical College of Wisconsin)H-Index: 5
Last.Leah C. Solberg Woods (Wake Forest University)H-Index: 11
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Type 2 diabetes is a complex disorder affected by multiple genes and the environment. Our laboratory has shown that in response to a glucose challenge, two-pore channel 2 (Tpcn2) knockout mice exhi...
#1Aaron C. BaldwinH-Index: 5
#2Aaron NaatzH-Index: 4
Last.John A. CorbettH-Index: 57
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#1Polly A. HansenH-Index: 31
#2Lorraine A. NolteH-Index: 25
Last.Jennifer S. McCartneyH-Index: 9
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#1John O. HolloszyH-Index: 112
#2Jonathan S. FisherH-Index: 15
Last.Tobias NygaardH-Index: 5
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#1Polly A. HansenH-Index: 31
#2Lorraine A. NolteH-Index: 25
Last.Ian R. W. RitchieH-Index: 8
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#1Robert C. HicknerH-Index: 38
#2John O. HolloszyH-Index: 112
Last.Edward O. OjukaH-Index: 11
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#1Lindsey E. Padgett (UAB: University of Alabama at Birmingham)H-Index: 7
#2Katarzyna A. Broniowska (MCW: Medical College of Wisconsin)H-Index: 18
Last.Hubert M. Tse (UAB: University of Alabama at Birmingham)H-Index: 22
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Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or prevents disease, respectively. CD4+ and CD8+ T cells use distinct effector mechanisms and act at different stages throughout T1D to fuel pancreatic β-cell destruction and disease ...
150 CitationsSource
#2John O. HolloszyH-Index: 112
Last.Helen H. HostH-Index: 10
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You might find this additional info useful...This article cites€25 articles, 17 of which you can access for free at: article has been cited by€21 other HighWire-hosted articles: Updated information and services including high resolution figures, can be found at: material and information about Journal of Applied Physiology can...
#1Teresa Andreone (SLU: Saint Louis University)H-Index: 2
#2Gordon P. Meares (UAB: University of Alabama at Birmingham)H-Index: 18
Last.John A. Corbett (MCW: Medical College of Wisconsin)H-Index: 57
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Poly(ADP)-ribose polymerase (PARP) is an abundant nuclear protein that is activated by DNA damage; once active, it modifies nuclear proteins through attachment of poly(ADP)-ribose units derived from β-nicotinamide adenine dinucleotide (NAD+). In mice, the deletion of PARP-1 attenuates tissue injury in a number of animal models of human disease, including streptozotocin-induced diabetes. Also, inflammatory cell signaling and inflammatory gene expression are attenuated in macrophages isolated from...
11 CitationsSource