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Bipasha Bose
Nanyang Technological University
Embryonic stem cellMolecular biologyAdult stem cellStem cellBiology
32Publications
6H-index
261Citations
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Publications 29
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#1Saketh KapoorH-Index: 5
#1Saketh KapoorH-Index: 1
Last. Bipasha BoseH-Index: 6
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The transmembrane phosphoglycoprotein protein CD34 has conventionally been regarded as a marker for hematopoietic progenitors. Its expression on these cells has been leveraged for cell therapy applications in various hematological disorders. More recently, the expression of CD34 has also been reported on cells of nonhematopoietic origin. The list includes somatic cells such as endothelial cells, fibrocytes and interstitial cells and regenerative stem cells such as corneal keratocytes, muscle sat...
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The ocular surface is subjected to regular wear and tear due to various environmental factors. Exposure to UV-C radiation constitutes an occupational health hazard. Here, we demonstrate the exposure of primary stem cells from the mouse ocular surface to UV-C radiation. Reactive oxygen species (ROS) formation is the readout of the extent of oxidative stress/damage. In an experimental in vitro setting, it is also essential to assess the percentage of dead cells generated due to oxidative stress. I...
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The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent unde...
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#1P. Sudheer ShenoyH-Index: 2
#2Utsav SenH-Index: 2
Last. Bipasha BoseH-Index: 6
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Abstract Fluoride is a well-known compound for its usefulness in healing dental caries. Similarly, fluoride is also known for its toxicity to various tissues in animals and humans. It causes skeletal fluorosis leading to osteoporosis of the bones. We hypothesized that when bones are affected by fluoride, the skeletal muscles are also likely to be affected by underlying molecular events involving myogenic differentiation. Murine myoblasts C2C12 were cultured in differentiation media with or witho...
1 CitationsSource
Pericytes are multipotent mesenchymal stem cells located on the walls of blood vessels in various organs and are characterized as CD146+ cells. In this study, we first immunohistochemically detected pericytes in the perivascular regions of liver from two mouse genotypes, namely wild-type (WT) and myostatin null (Mstn-/- ). We further isolated pericytes using sorting as CD146+ CD34- CD56- CD45- cells. The main finding of this study involves the contrasting fibrogenic vs. myogenic behaviour of liv...
4 CitationsSource
#1Bipasha BoseH-Index: 6
#2Utsav SenH-Index: 2
Last. Sudheer Shenoy PH-Index: 3
view all 3 authors...
Relapse cases of cancers are more vigorous and difficult to control due to the preponderance of cancer stem cells (CSCs). Such CSCs that had been otherwise dormant during the first incidence of cancer gradually appear as radiochemoresistant cancer cells. Hence, cancer therapeutics aimed at CSCs would be an effective strategy for mitigating the cancers during relapse. Alternatively, CSC therapy can also be proposed as an adjuvant therapy, along-with the conventional therapies. As regenerative ste...
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#1P. Sudheer Shenoy (Yenepoya University)H-Index: 2
#2Bipasha Bose (Yenepoya University)H-Index: 6
Abstract Mesenchymal stem cells (MSCs) constitute the diverse progenitor populations in almost every tissue and are of immense importance in the field of regenerative medicine. CD34 is a cell surface glycoprotein identified first as a marker for the MSCs of hematopoietic origin. CD34 is now known to be expressed in cells of diverse lineages (tissues of non-hematopoietic origin) such as ectoderm, mesoderm and endoderm and is considered as a general marker for progenitor cells. Here, we present de...
1 CitationsSource
#1Utsav SenH-Index: 2
#2Sudheer Shenoy PH-Index: 3
Last. Bipasha BoseH-Index: 6
view all 3 authors...
Colorectal cancer is one of the global causes of cancer deaths. Cancer stem cells (CSCs) inside the tumour niche responsible for metastasis and relapses, and hence need to be targeted for cancer therapeutics. Although dietary fibre and lifestyle changes have been recommended as measures for colorectal cancer prevention, no such recommendations are available for using water soluble vitamins as prophylaxis measure for colorectal cancers. High dose of Vitamin C has been proven to selectively kill c...
1 CitationsSource
#1Bipasha Bose (Yenepoya University)H-Index: 6
#2Shenoy P S (Yenepoya University)H-Index: 1
Muscle derived stem cells (MDSCs) are multipotent stem cells that can differentiate into several lineages including skeletal muscle precursor cells. Here, we show that MDSCs from myostatin null mice (Mstn −/− ) can be readily induced into pluripotent stem cells without using reprogramming factors. Microarray studies revealed a strong upregulation of markers like Leukemia Inhibitory factor (LIF) and Leukemia Inhibitory factor receptor (LIFR) in Mstn −/− MDSCs as compared to wild type MDSCs (WT-MD...
2 CitationsSource
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