Fred Luciano Neves Santos
Oswaldo Cruz Foundation
VirologyTrypanosoma cruziSerologyMedicineBiology
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Publications 35
#1E. DopicoH-Index: 4
#1Eva DopicoH-Index: 2
Last. T. Vinuesa (University of Barcelona)
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To evaluate co-infection of Strongyloides stercoralis and Trypanosoma cruzi and to assess eosinophilia as a screening test for the detection of S. stercoralis infection in patients with Chagas disease (CD). methods A retrospective diagnostic validation study was performed on serum samples from primary care patients diagnosed with CD in the southern Barcelona metropolitan area. All samples with eosinophilia (n = 87) and a random sample of non-eosinophilic sera (n = 180) were selected. Diagnosis o...
#2Fred Luciano Neves Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
Last. Adele Caterino-de-AraujoH-Index: 8
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Difficulties to confirm and discriminate human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) infections by serological Western Blotting (WB) assay (HTLV Blot 2.4, MP Biomedicals) has been reported in Brazil, mainly in HIV/AIDS patients, with a large number of WB-indeterminate and WB-positive but HTLV untypeable results. Nonetheless, the line immunoassay (LIA) (INNO-LIA HTLV-I/II, Fujirebio) was pointed to enhance specificity and sensitivity for confirming HTLV-1/2 infections. To ad...
1 CitationsSource
Both Human T-lymphotropic virus type 1 (HTLV-1) and hepatitis C virus (HCV) are endemic in Brazil. In Salvador, the capital of the state of Bahia, 2% and 1.5% of the general population is infected with HTLV-1 or HCV. This study aimed to estimate the prevalence and the distribution of HTLV/HCV coinfection in Bahia. This cross-sectional study was conducted at the Central Laboratory of Public Health for the state of Bahia (LACEN-BA). All samples in the LACEN database submitted to serological testin...
#1Diego Lopes Paim Miranda (FIOCRUZ: Oswaldo Cruz Foundation)
#2Gilmar Ribeiro (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
Last. Mitermayer G. Reis (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 43
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The School of Medicine of the Federal University of Bahia, Oswaldo Cruz Foundation, and Foundation of Hematology and Hemotherapy of Bahia.
#1Neci Matos Soares (UFBA: Federal University of Bahia)H-Index: 9
#2Helen C. Azevedo (UFBA: Federal University of Bahia)
Last. Fred Luciano Neves Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
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Epidemiological studies on species-specific Entamoeba infections are scarce due to the morphological similarity of pathogenic Entamoeba histolytica and nonpathogenic E. dispar and E. moshkovskii. The diagnosis of E. histolytica is frequently based on coproantigen (E. histolytica-Gal/GalNAc lectin specific) detection by immunoassays. However, specific E. histolytica-lectin is not expressed in cysts, which are eliminated by asymptomatic individuals leading to false-negative results and an underest...
#1Leonardo Maia Leony (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
#2Natália Erdens Maron Freitas (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
Last. Fred Luciano Neves Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
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Background Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exposure in humans. For human sera, these chimeric antigens presented superior diagnostic ...
#1Ramona Tavares Daltro (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
#2Leonardo Maia Leony (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
Last. Fred Luciano Neves Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
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ABSTRACT Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp. Our group expressed four chimeric proteins (IBMP-8.1, IBMP-8.2, IBMP-8.3, and IBMP-8.4) and previously assessed their diagnostic performance...
1 CitationsSource
#1Felicidade Mota Pereira (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
#2Maria da Conceição Chagas de Almeida (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 13
Last. Maria Fernanda Rios Grassi (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 10
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Background: Salvador, Bahia (northeastern Brazil), has been identified as the epicenter of Human T-cell leukemia virus Human T-cell leukemia virus (HTLV) type 1 infection in the country. This study aims to estimate the rate of HTLV infection and the geographical distribution of this virus in this state. Methods All HTLV tests (chemiluminescence/ELISA assays/Western Blotting) performed in the Central Laboratory of Public Health of Bahia (LACEN) from 2004 to 2013 were included. Data was extracted ...
1 CitationsSource
Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. cruzi in different geographical settings. The use of antigenic matrices based on chimeric proteins can solve these limitations. Here, we evaluated the diagnostic performance of two chimeric T. ...
1 CitationsSource
#1Eva DopicoH-Index: 2
Last. Fred Luciano Neves Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
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Background Chronic Chagas Disease (CD) diagnosis is based on serological methods employing crude, semipurified or recombinant antigens, which may result in low sensitivity or cross-reactivity. To reduce these restrictions, we developed a strategy involving use of molecules containing repetitive fragments of Trypanosoma cruzi conserved proteins. Diagnostic performance of IBMP-8.1 and IBMP-8.4 chimeric antigens (Molecular Biology Institute of Parana - IBMP in Portuguese acronym) was assessed to di...
2 CitationsSource