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Seongyeol Park
KAIST
19Publications
6H-index
172Citations
Publications 19
Newest
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
view all 20 authors...
The originally published version of this Article contained an error in Figure 2. In panel g, the image of brown adipose tissue from SCD-fed Tph1 GKO mice (top-right) was inadvertently replaced with the equivalent image of SCD-fed WT mice (top-left) during assembly of the figure. This error has now corrected in both the PDF and HTML versions of the Article.
Source
#1Hyung-Don Kim (KAIST)H-Index: 2
#2Seongyeol Park (KAIST)H-Index: 6
Last.Su-Hyung Park (KAIST)H-Index: 8
view all 18 authors...
2 CitationsSource
#1Jimyung Seo (KAIST)H-Index: 1
#2Min Hwan Kim (Yonsei University)H-Index: 2
Last.Joon Kim (KAIST)H-Index: 22
view all 7 authors...
Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. Here we present a functional screen and identify a novel therapeutic target for YAP-driven tumorigenesis. RNAi screening using an oncogenic YAP activation model identified the serine/...
1 CitationsSource
#1Jake June-Koo Lee (Harvard University)H-Index: 1
#2Seongyeol Park (KAIST)H-Index: 6
Last.Young Tae Kim (SNU: Seoul National University)H-Index: 42
view all 18 authors...
Summary Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain elusive. We analyzed 138 LADC whole genomes, including 83 cases with minimal contribution of smoking-associated mutational signature. Genomic rearrangements were not correlated with smoking-associated mutations and frequently served as driver events of smoking-signature-low LADCs. Complex genomic rearrangements, including chromothripsis and chromoplexy, generated 74% of known fusion oncogenes, includin...
2 CitationsSource
#1Hyung-Don Kim (KAIST)H-Index: 2
#2Gi-Won Song (UOU: University of Ulsan)H-Index: 24
Last.Su-Hyung Park (KAIST)H-Index: 8
view all 16 authors...
Background & Aims T-cell exhaustion, or an impaired capacity to secrete cytokines and proliferate with overexpression of immune checkpoint receptors, occurs during chronic viral infections but has also been observed in tumors, including hepatocellular carcinomas (HCCs). We investigated features of exhaustion in CD8+ T cells isolated from HCC specimens. Methods We obtained HCC specimens, along with adjacent nontumor tissues and blood samples, from 90 patients who underwent surgical resection at A...
19 CitationsSource
#1Wonsuk Choi (KAIST)H-Index: 2
#2Jun Namkung (KAIST)H-Index: 4
Last.Hail Kim (KAIST)H-Index: 20
view all 20 authors...
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in th...
7 CitationsSource
#1June Koo Lee (Harvard University)H-Index: 15
#2Seongyeol Park (KAIST)H-Index: 6
Last.Young Seok Ju (KAIST)H-Index: 19
view all 5 authors...
Purpose: Recently, we performed a whole-genome sequencing (WGS) study of serially acquired tumors and demonstrated that an early, complete inactivation of RB1 and TP53 is common among patients with EGFR-mutant lung adenocarcinoma (LADC) whose disease was transformed into small cell lung cancer (SCLC). To further understand this phenomenon, here we functionally characterized a patient-derived cell line of transformed SCLC and related in vitro models. We also deepened our genome analysis focusing ...
Source
#1Sung Yup Cho (Ewha Womans University)H-Index: 2
#2Chang Ohk Sung (UOU: University of Ulsan)H-Index: 21
Last.Cheryl T. Lee (Ewha Womans University)H-Index: 92
view all 34 authors...
Epstein-Barr virus (EBV)-positive diffuse large B cell lymphomas (EBV + -DLBLs) tend to occur in immunocompromised patients, such as the elderly or those undergoing solid organ transplantation. The pathogenesis and genomic characteristics of EBV + -DLBLs are largely unknown because of the limited availability of human samples and lack of experimental animal models. We observed the development of 25 human EBV + -DLBLs during the engraftment of gastric adenocarcinomas into immunodeficient mice. An...
Source
#1Il-Kug Kim (KAIST)H-Index: 2
#2Kangsan Kim (KAIST)H-Index: 7
Last.Injune Kim (KAIST)H-Index: 37
view all 20 authors...
High-grade glioma (HGG) is highly angiogenic, but antiangiogenic therapy has transient clinical benefit in only a fraction of patients. Vascular regulators of these heterogeneous responses remain undetermined. We found up-regulation of Sox7 and down-regulation of Sox17 in tumor endothelial cells (tECs) in mouse HGG.Sox7deletion suppressed VEGFR2 expression, vascular abnormality, hypoxia-driven invasion, regulatory T cell infiltration, and tumor growth. Conversely,Sox17deletion exacerbated these ...
10 CitationsSource
#1Vishal ChandraH-Index: 10
#2Yong-Bock ChoiH-Index: 5
Last.Kyeong Man HongH-Index: 9
view all 10 authors...
We have shown both LLC1 expression in the lung epithelium by in situ hybridization and its inactivation in lung cancer by epigenetic modification. However, LLC1 protein's cellular localization or its role in normal lung or cancer tissues has not yet been evaluated. In the present study, a monoclonal antibody against recombinant LLC1 was produced, and immunohistochemical staining was performed on arrays including various human tissues, normal lung and non-small cell lung cancer (NSCLC) tissues fo...
3 CitationsSource
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