Match!
Philip Britz-McKibbin
McMaster University
Analytical chemistryChemistryMetabolomicsCapillary electrophoresisChromatography
98Publications
26H-index
2,618Citations
What is this?
Publications 103
Newest
#1Sandi AzabH-Index: 1
Last. Mohammad QaduraH-Index: 4
view all 5 authors...
Source
#1Sandi AzabH-Index: 1
Last. Philip Britz-McKibbinH-Index: 26
view all 3 authors...
Source
Peripheral artery disease (PAD) is characterized by the atherosclerotic narrowing of lower limb vessels, leading to ischemic muscle pain in older persons. Some patients experience progression to advanced chronic limb-threatening ischemia (CLTI) with poor long-term survivorship. Herein, we performed serum metabolomics to reveal the mechanisms of PAD pathophysiology that may improve its diagnosis and prognosis to CLTI complementary to the ankle–brachial index (ABI) and clinical presentations. Non-...
Source
#1Michelle Saoi (McMaster University)H-Index: 2
#2Katherine M. Kennedy (McMaster University)
Last. Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 5 authors...
The placenta is a metabolically active interfacial organ that plays crucial roles in fetal nutrient delivery, gas exchange and waste removal reflecting dynamic maternal and fetal interactions during gestation. There is growing evidence that the sex of the placenta influences fetal responses to external stimuli in utero, such as changes in maternal nutrition and exposure to environmental stressors. However, the exact biochemical mechanisms associated with sex-specific metabolic adaptations during...
Source
#1Lara Hart (McMaster Children's Hospital)
#2Yasamin Farbod (McMaster Children's Hospital)
Last. Nikhil Pai (McMaster Children's Hospital)H-Index: 5
view all 8 authors...
Introduction: Exclusive enteral nutrition (EEN) and corticosteroids (CS) are effective induction therapies for pediatric Crohn’s Disease (CD). CS are also therapy for ulcerative colitis (UC). Host–microbe interactions may be able to explain the effectiveness of these treatments. This is the first prospective study to longitudinally characterize compositional changes in the bacterial community structure of pediatric UC and CD patients receiving EEN or CS induction therapy. Methods: Patients with ...
Source
Abstract Biomonitoring of exposures to toxic contaminants from environmental smoke is important given their deleterious impacts on human health, including cardiorespiratory diseases and cancer. This is particularly relevant for firefighters who are prone to extensive dermal exposure to smoke despite using personalized protective equipment. Reliable methods are needed for the analysis of sensitive yet specific biomarkers reflecting occupational smoke exposure given various background sources. Thi...
Source
#1Sandi Azab (McMaster University)H-Index: 1
#2Russell J. de Souza (McMaster University)H-Index: 34
Last. Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 9 authors...
Nutritional studies rely on various biological specimens for fatty acid (FA) determination, yet it is unclear how levels of serum non-esterified FA (NEFAs) correlate with other circulating lipid pools. Here, we used a high throughput method (< 4 min/sample) based on multisegment injection-non-aqueous-capillary electrophoresis-mass spectrometry (MSI-NACE-MS) to investigate whether specific serum NEFAs have utility as biomarkers of dietary fat intake in women. We first identified circulating NEFAs...
2 CitationsSource
#1Nadine Wellington (McMaster University)H-Index: 1
#2Sabrina Macklai (McMaster University)
Last. Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 3 authors...
A zwitterionic heterocyclic boronic acid based on 4-isoquinolineboronic acid (IQBA) exhibits the highest reported binding affinity for sialic acid or N-acetylneuraminic acid (Neu5Ac, K=5390+/-190 m(-1) ) through the formation of a cyclic boronate ester complex under acidic conditions (pH 3). This anomalous pH-dependent binding enhancement does not occur with common neutral saccharides (e.g., glucose, fructose, sorbitiol), because it is mediated via selective complexation to a alpha-hydroxycarbox...
Source
#1Jennifer Wild (McMaster University)H-Index: 1
#2Meera Shanmuganathan (McMaster University)H-Index: 4
Last. Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 5 authors...
Management of phenylketonuria (PKU) requires lifelong restriction of phenylalanine (Phe) intake using specialized medical foods to prevent neurocognitive impairment in affected patients. However, dietary adherence is challenging to maintain while ensuring adequate nutrition, which can lead to sub-optimal clinical outcomes. Metabolomics offers a systematic approach to identify new biomarkers of disease progression in PKU when using urine as a surrogate for blood specimens that is more accurate th...
6 CitationsSource
#1Nadine WellingtonH-Index: 1
Last. Philip Britz-McKibbinH-Index: 26
view all 11 authors...
A large body of evidence has linked unhealthy eating patterns with an alarming increase in obesity and chronic disease worldwide. However, existing methods of assessing dietary intake in nutritional epidemiology rely on food frequency questionnaires or dietary records that are prone to bias and selective reporting. Herein, metabolic phenotyping was performed on 42 healthy participants from the Diet and Gene Intervention (DIGEST) pilot study, a parallel two-arm randomized clinical trial that prov...
10 CitationsSource
12345678910