Philip Britz-McKibbin
McMaster University
Publications 98
#1Nadine WellingtonH-Index: 1
Last.Philip Britz-McKibbinH-Index: 26
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A large body of evidence has linked unhealthy eating patterns with an alarming increase in obesity and chronic disease worldwide. However, existing methods of assessing dietary intake in nutritional epidemiology rely on food frequency questionnaires or dietary records that are prone to bias and selective reporting. Herein, metabolic phenotyping was performed on 42 healthy participants from the Diet and Gene Intervention (DIGEST) pilot study, a parallel two-arm randomized clinical trial that prov...
#1Michelle Saoi (McMaster University)H-Index: 2
#2Kazunori SasakiH-Index: 4
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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Nonalcoholic fatty liver disease (NAFLD) is the most common preventable chronic liver disorder in developed countries, the prevalence of which is increasing worldwide due to its association with obesity and type 2 diabetes. However, the exact mechanisms of NAFLD pathophysiology remain poorly understood including its progression to the more severe nonalcoholic steatohepatitis (NASH). New advances for early detection and monitoring of NASH progression are limited due to the lack of specific blood ...
#1Michelle SaoiH-Index: 2
#2Alice LiH-Index: 1
Last.Philip Britz-McKibbinH-Index: 26
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Sarcopenia is the age-related loss of skeletal muscle mass, strength and function, which may be accelerated during periods of physical inactivity. Declines in skeletal muscle and functionality not only impacts mobility but also increases chronic disease risk, such as type 2 diabetes. The aim of this study was to measure adaptive metabolic responses to acute changes in habitual activity in a cohort of overweight, pre-diabetic older adults (age = 69 ± 4 years; BMI = 27 ± 4 kg/m2, n = 17) when usin...
#1Mai Yamamoto (McMaster University)H-Index: 2
#2Maria Ines Pinto-Sanchez (McMaster University)H-Index: 9
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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Introduction Irritable bowel syndrome (IBS), the most commonly diagnosed functional gastrointestinal (GI) disorder in developed countries, is characterized by chronic abdominal pain, and altered bowel habits.
#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Sabrina Macklai (McMaster University)
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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New analytical methods are urgently needed to enable high-throughput, yet comprehensive drug screening, given an alarming opioid and prescription drug crisis in public health. Conventional urine drug testing based on a two-tier immunoassay screen followed by a gas chromatography-tandem mass spectrometry (GC-MS/MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS) method are expensive and prone to bias while being limited to targeted panels of known drugs of abuse (DoA). Herein, we out...
#1Michelle Saoi (McMaster University)H-Index: 2
#2Michael E. Percival (McMaster University)H-Index: 9
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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Bicarbonate has long been touted as a putative ergogenic aid that improves exercise performance and blood buffering capacity during strenuous exercise. However, the underlying mechanisms of action of bicarbonate intake on skeletal muscle metabolism have yet to be fully elucidated. Herein, we apply two orthogonal analytical platforms for nontargeted profiling of metabolites and targeted analysis of electrolytes from mass-limited muscle tissue biopsies (∼2 mg dried mass) when multisegment injectio...