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Sofie L. Valk
University of Düsseldorf
Developmental psychologyPsychologyCognitive psychologyConnectomeNeuroimaging
24Publications
8H-index
259Citations
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Publications 33
Newest
#1Bo-yong Park (Montreal Neurological Institute and Hospital)
#1Bo-Yong Park (Montreal Neurological Institute and Hospital)
Last. B.T. Thomas Yeo (NUS: National University of Singapore)H-Index: 26
view all 12 authors...
Both macroscale connectome miswiring and microcircuit anomalies have been suggested to play a role in the pathophysiology of autism. However, an overarching framework that consolidates these macro and microscale perspectives of the condition is lacking. Here, we combined connectome-wide manifold learning and biophysical simulation models to understand associations between global network perturbations and microcircuit dysfunctions in autism. Our analysis established that autism showed significant...
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#1Sofie L. Valk (Forschungszentrum Jülich)H-Index: 8
#2F. Hoffstaedter (Forschungszentrum Jülich)
Last. Simon B. Eickhoff (Forschungszentrum Jülich)H-Index: 86
view all 6 authors...
Local variation in cortical architecture is highly heritable and distinct genes are associated with specific cortical regions. Total surface area has been shown to be genetically correlated with complex cognitive capacities, suggesting cortical brain structure is a viable endophenotype linking genes to behavior. However, to what extend local brain structure has a genetic association with cognitive and emotional functioning is incompletely understood. Here, we study the genetic correlation betwee...
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#2Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
Last. Felix HoffstaedterH-Index: 16
view all 15 authors...
In recent years, replicability of neuroscientific findings, specifically those concerning correlates of morphological properties of gray matter (GM), have been subject of major scrutiny. Use of different processing pipelines and differences in their estimates of the macroscale GM may play an important role in this context. To address this issue, here, we investigated the cortical thickness estimates of three widely used pipelines. Based on analyses in two independent large-scale cohorts, we repo...
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#1Masoud Tahmasian (Shahid Beheshti University)H-Index: 18
#2Fateme Samea (Shahid Beheshti University)H-Index: 3
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 11 authors...
Humans need about seven to nine hours of sleep per night. Sleep habits are heritable, associated with brain function and structure, and intrinsically related to well-being, mental, and physical health. However, the biological basis of the interplay of sleep and health is incompletely understood. Here we show, by combining neuroimaging and behavioral genetic approaches in two independent large-scale datasets (HCP (n = 1106), age range: 22–37, eNKI (n = 783), age range: 12–85), that sleep, mental,...
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#1Reinder Vos de Wael (Montreal Neurological Institute and Hospital)H-Index: 5
#2Oualid M. Benkarim (Montreal Neurological Institute and Hospital)H-Index: 6
Last. Sofie L. Valk (HHU: University of Düsseldorf)H-Index: 8
view all 15 authors...
Understanding how cognitive functions emerge from brain structure depends on quantifying how discrete regions are integrated within the broader cortical landscape. Recent work established that macroscale brain organization and function can be described in a compact manner with multivariate machine learning approaches that identify manifolds often described as cortical gradients. By quantifying topographic principles of macroscale organization, cortical gradients lend an analytical framework to s...
9 CitationsSource
#1Sofie L. Valk (Forschungszentrum Jülich)H-Index: 8
#2Ting Xu (MIND Institute)H-Index: 20
Last. Boris C. Bernhardt (Montreal Neurological Institute and Hospital)H-Index: 31
view all 11 authors...
Structural and functional characteristics of the cortex systematically vary along global axes as a function of cytoarchitecture, gene expression, and connectivity. The topology of the cerebral cortex has been proposed to be a prerequisite for the emergence of human cognition and explain both the impact and progression of pathology. However, the neurogenetic origin of these organizational axes in humans remains incompletely understood. To address this gap in the literature our current study asses...
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#1Sofie L. Valk (HHU: University of Düsseldorf)H-Index: 8
#2F. Hoffstaedter (Forschungszentrum Jülich)
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 6 authors...
Personality traits are key indices of inter-individual variation. Personality is heritable and has been associated with brain structure and function. To date, it is unknown whether the relation between personality and brain macrostructure can be explained by genetic factors. In a large-scale twin sample (Human Connectome Project), we performed genetic correlation analyses to evaluate whether personality traits (NEO-FFI) and local brain structure have a shared genetic basis. We found a genetic ov...
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#1Lara M. Puhlmann (MPG: Max Planck Society)H-Index: 1
#2Sofie L. Valk (HHU: University of Düsseldorf)H-Index: 8
Last. Tania Singer (MPG: Max Planck Society)H-Index: 47
view all 8 authors...
Importance Telomere length is associated with the development of age-related diseases and structural differences in multiple brain regions. It remains unclear, however, whether change in telomere length is linked to brain structure change, and to what extent telomere length can be influenced through mental training. Objectives To assess the dynamic associations between leukocyte telomere length (LTL) and cortical thickness (CT), and to determine whether LTL is affected by a longitudinal contempl...
1 CitationsSource
#1Lara M. Puhlmann (MPG: Max Planck Society)H-Index: 1
#2Sofie L. ValkH-Index: 8
Last. Tania Singer (MPG: Max Planck Society)H-Index: 47
view all 8 authors...
#1Sofie L. Valk (HHU: University of Düsseldorf)H-Index: 8
#2Felix Hoffstaedter (HHU: University of Düsseldorf)H-Index: 16
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 6 authors...
Personality traits are key indices of inter-individual variation. Personality is heritable and associated with brain structure and function. To date, it is unknown whether the relation between personality and brain macrostructure can be explained by shared genetic factors. In a large-scale twin sample, we show that key personality traits, e.g. agreeableness and extraversion, were genetically associated with thickness of specific brain regions. Second, we observed that spatial patterns of phenoty...
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