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Ana García-Martínez
University of Barcelona
PathologyVasculitisGiant cell arteritisArteritisMedicine
54Publications
23H-index
1,700Citations
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Publications 55
Newest
#1Oscar Miró Andreu (University of Barcelona)H-Index: 40
#2Pedro Lopez-AyalaH-Index: 2
Last. Mar Ortega Romero (University of Barcelona)H-Index: 20
view all 18 authors...
BackgroundWe aimed to externally validate an emergency department triage algorithm including five hierarchical clinical variables developed to identify chest pain patients at low risk of having an ...
Source
#1Georgina Espígol-Frigolé (University of Barcelona)H-Index: 21
#2Ester Planas-Rigol (University of Barcelona)H-Index: 11
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 10 authors...
Background: Giant-cell arteritis (GCA) is considered a T helper (Th)1 and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 response. Objectives: The aims of this study were: to investigate p40, p35 and p19 subunit expression in GCA lesions and their combinations to conform different cytokines, to assess the effect of glucoco...
4 CitationsSource
#1Sergio Prieto-González (University of Barcelona)H-Index: 21
#2Nekane Terrades-García (University of Barcelona)H-Index: 5
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 15 authors...
Background Osteopontin (OPN) is a glycoprotein involved in Th1 and Th17 differentiation, tissue inflammation and remodelling. We explored the role of serum OPN (sOPN) as a biomarker in patients with giant cell arteritis (GCA). Methods sOPN was measured by immunoassay in 76 treatment-naive patients with GCA and 25 age-matched and sex-matched controls. In 36 patients, a second measurement was performed after 1 year of glucocorticoid treatment. Baseline clinical and laboratory findings, as well as ...
4 CitationsSource
Source
#1Sergio Prieto-González (University of Barcelona)H-Index: 21
#2Georgina Espígol-Frigolé (University of Barcelona)H-Index: 21
Last. M.C. Cid Xutglá (University of Barcelona)
view all 5 authors...
Resumen Definicion La fiebre constituye un sintoma frecuente en un paciente con vasculitis sistemica. Diagnostico diferencial Puede indicar actividad de la enfermedad al comienzo de la misma, especialmente antes del inicio del tratamiento, o durante la evolucion ser un signo de rebrote o recurrencia. Su aparicion, en un paciente ya diagnosticado y tratado, siempre nos obligara ademas a descartar una infeccion. Asimismo, no hay que olvidar que otras entidades que cursan con fiebre pueden presenta...
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#1Sergio Prieto-González (University of Barcelona)H-Index: 21
#2Georgina Espígol-Frigolé (University of Barcelona)H-Index: 21
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 10 authors...
15 CitationsSource
Background Giant cell arteritis (GCA) may be complicated by aortic dilatation/aneurysm (aortic structural damage; ASD), which may lead to life-threatening events. In GCA patients, ASD occurs 17.3 times more frequently than in the general population, affecting up to 33.3% of patients after long term follow-up 1 . ASD is in most cases a delayed complication and its pathophysiology is unclear. Necropsy/surgery specimens from patients subjected to standard treatment and control may reveal persistent...
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#1Marc Corbera-Bellalta (University of Barcelona)H-Index: 10
#2Ester Planas-Rigol (University of Barcelona)H-Index: 11
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 16 authors...
Background Interferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant cell arteritis (GCA), but its functional role has not been investigated. We explored changes in infiltrating cells and biomarkers elicited by blocking IFNγ with a neutralising monoclonal antibody, A6, in temporal arteries from patients with GCA. Methods Temporal arteries from 34 patients with GCA (positive histology) and 21 controls were cultured on 3D matrix (Matrigel) and exposed to A6 or recombinant I...
32 CitationsSource
Background Giant cell arteritis (GCA) is a granulomatous vasculitis preferentially targeting the carotid and vertebral artery branches. Aortic involvement is common and may lead to severe complications such as aortic dilatation/aneurysm or dissection 1 . While small necropsy studies detected histopathologically-proven aortic inflammation in more than 90% of patients, aortic wall thickening suggesting aortitis is detected in 65% of patients using CTA at diagnosis 2 . We hypothesized that histolog...
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#1Sergio Prieto-González (University of Barcelona)H-Index: 21
#2Ana García-Martínez (University of Barcelona)H-Index: 23
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 4 authors...
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