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Akihiko Kondo
Kobe University
842Publications
70H-index
20.1kCitations
Publications 804
Newest
#1Keisuke Morita (Osaka University)H-Index: 2
#2Fumio Matsuda (Osaka University)H-Index: 38
Last.Hiroshi Shimizu (Osaka University)H-Index: 37
view all 6 authors...
Background Saccharomyces cerevisiae is a suitable host for the industrial production of pyruvate-derived chemicals such as ethanol and 2,3-butanediol (23BD). For the improvement of the productivity of these chemicals, it is essential to suppress the unnecessary pyruvate consumption in S. cerevisiae to redirect the metabolic flux toward the target chemical production. In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repre...
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#1Nathan J. HillsonH-Index: 24
#2Mark X. Caddick (University of Liverpool)H-Index: 30
Last.Paul S. Freemont (Imperial College London)H-Index: 66
view all 36 authors...
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#1Nathan J. HillsonH-Index: 24
#2Mark X. Caddick (University of Liverpool)H-Index: 30
Last.Paul S. Freemont (Imperial College London)H-Index: 66
view all 36 authors...
The original version of this Comment contained errors in the legend of Figure 2, in which the locations of the fifteenth and sixteenth GBA members were incorrectly given as ‘(15) Australian Genome Foundry, Macquarie University; (16) Australian Foundry for Advanced Biomanufacturing, University of Queensland.’. The correct version replaces this with ‘(15) Australian Foundry for Advanced Biomanufacturing (AusFAB), University of Queensland and (16) Australian Genome Foundry, Macquarie University’. T...
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#1Nathan J. HillsonH-Index: 24
#2Mark X. Caddick (University of Liverpool)H-Index: 30
Last.Paul S. Freemont (Imperial College London)H-Index: 66
view all 36 authors...
Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.
2 CitationsSource
#1Shuhei NodaH-Index: 11
#2Yutaro MoriH-Index: 7
Last.Tomokazu ShiraiH-Index: 14
view all 6 authors...
Background The microbial production of useful fuels and chemicals has been widely studied. In several cases, glucose is used as the raw material, and almost all microbes adopt the Embden–Meyerhof (EM) pathway to degrade glucose into compounds of interest. Recently, the Entner–Doudoroff (ED) pathway has been gaining attention as an alternative strategy for microbial production.
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#1Yuri Sakihama (Kobe University)H-Index: 4
#2Ryota Hidese (Kobe University)H-Index: 8
Last.Akihiko Kondo (Kobe University)H-Index: 70
view all 4 authors...
Yeasts are extremely useful, not only for fermentation but also for a wide spectrum of fuel and chemical productions. We analyzed the overall metabolic turnover and transcript dynamics in glycolysis and the TCA cycle, revealing the difference in adaptive pyruvate metabolic response between a Crabtree-negative species, Kluyveromyces marxianus, and a Crabtree-positive species, Saccharomyces cerevisiae, during aerobic growth. Pyruvate metabolism was inclined toward ethanol production under aerobic ...
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#1Takahiro Bamba (Kobe University)H-Index: 4
#2Takahiro Yukawa (Kobe University)
Last.Akihiko Kondo (Kobe University)H-Index: 70
view all 7 authors...
Abstract 1,2,4-Butanetriol can be used to produce energetic plasticizer as well as several pharmaceutical compounds. Although Saccharomyces cerevisiae has some attractive characters such as high robustness for industrial production of useful chemicals by fermentation, 1,2,4-butanetriol production by S. cerevisiae has not been reported. 1,2,4-butanteriotl is produced by an oxidative xylose metabolic pathway completely different from the xylose reductase-xylitol dehydrogenase and the xylose isomer...
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#1Yuichi Kato (Kobe University)H-Index: 3
#2Yusuke Fujihara (Kobe University)H-Index: 1
Last.Akihiko Kondo (Kobe University)H-Index: 70
view all 6 authors...
Light/dark cycling is an inevitable outdoor culture condition for microalgal biofuel production; however, the influence of this cycling on cellular lipid production has not been clearly established. The general aim of this study was to determine the influence of light/dark cycling on microalgal biomass production and lipid accumulation. To achieve this goal, specific causative mechanisms were investigated using a metabolomics approach. Laboratory scale photoautotrophic cultivations of the oleagi...
2 CitationsSource
#1Christopher J. Vavricka (Kobe University)H-Index: 15
#2Takanobu Yoshida (Kobe University)H-Index: 2
Last.Akihiko Kondo (Kobe University)H-Index: 70
view all 15 authors...
Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) is identified to bypass MAO and DDC for direct production of 3,4-dihydroxyphenylacetaldehyde (DHPAA) from L-3,4-dihydroxyphenylalanine (L-DOPA). Struc...
1 CitationsSource
#1Daisuke Sasaki (Kobe University)H-Index: 15
#2Kengo Sasaki (Kobe University)H-Index: 18
Last.Akihiko Kondo (Kobe University)H-Index: 70
view all 4 authors...
Background Using a microbial fuel cell (MFC), we observed that a complex microbial community decomposed starch and transferred electrons to a graphite felt anode to generate current. In spite of the same reactor configuration, inoculum, substrate, temperature, and pH, MFCs produced different current and power density. To understand which factor(s) affected electricity generation, here, we analyzed a complex microbial community in an anodic biofilm and fermentation broth using Illumina MiSeq sequ...
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