Pankaj K. Agarwal
GlaxoSmithKline
541Publications
59H-index
19.1kCitations
Publications 541
Published on Feb 8, 2019in BMC Bioinformatics 2.21
Jin Yao1
Estimated H-index: 1
,
Mark R. Hurle7
Estimated H-index: 7
+ 1 AuthorsPankaj K. Agarwal59
Estimated H-index: 59
Background Determining which target to pursue is a challenging and error-prone first step in developing a therapeutic treatment for a disease, where missteps are potentially very costly given the long-time frames and high expenses of drug development. With current informatics technology and machine learning algorithms, it is now possible to computationally discover therapeutic hypotheses by predicting clinically promising drug targets based on the evidence associating drug targets with disease i...
Published on Jun 18, 2019 in Symposium on Computational Geometry
Pankaj K. Agarwal59
Estimated H-index: 59
(GlaxoSmithKline),
Allen Xiao1
Estimated H-index: 1
Published on Jun 18, 2019 in Symposium on Computational Geometry
Ravid Cohen1
Estimated H-index: 1
,
Dan Halperin32
Estimated H-index: 32
(Tel Aviv University)
+ 1 AuthorsWolfgang Mulzer13
Estimated H-index: 13
(Free University of Berlin)
We present efficient data structures for problems on unit discs and arcs of their boundary in the plane. (i) We give an output-sensitive algorithm for the dynamic maintenance of the union of $n$ unit discs under insertions in $O(k \log^2 n)$ update time and $O(n)$ space, where $k$ is the combinatorial complexity of the structural change in the union due to the insertion of the new disc. (ii) As part of the solution of (i) we devise a fully dynamic data structure for the maintenance of lower enve...
Published on Jun 18, 2019 in Symposium on Computational Geometry
Pankaj K. Agarwal59
Estimated H-index: 59
(GlaxoSmithKline),
Boris Aronov1
Estimated H-index: 1
+ 1 AuthorsJoshua Zahl8
Estimated H-index: 8
(University of British Columbia)
Guth showed that given a family $\mathcal{S}$ of $n$ $g$-dimensional semi-algebraic sets in $\mathbb{R}^d$ and an integer parameter $D \geq 1$, there is a $d$-variate partitioning polynomial $P$ of degree at most $D$, so that each connected component of $\mathbb{R}^d \setminus Z(P)$ intersects $O(n / D^{d-g})$ sets from $\mathcal{S}$. Such a polynomial is called a "generalized partitioning polynomial". We present a randomized algorithm that efficiently computes such a polynomial $P$. Specificall...
Published on May 9, 2019in Discrete and Computational Geometry 0.67
Pankaj K. Agarwal59
Estimated H-index: 59
,
Jiangwei Pan4
Estimated H-index: 4
Source Cite
Published on Apr 19, 2019in PLOS ONE 2.77
William C. Reisdorf4
Estimated H-index: 4
,
Qing Xie3
Estimated H-index: 3
+ 15 AuthorsDeepak K. Rajpal13
Estimated H-index: 13
Source Cite
Published on Mar 8, 2019in bioRxiv
William C. Reisdorf4
Estimated H-index: 4
(GlaxoSmithKline),
Neetu Rajpal (GlaxoSmithKline)+ 5 AuthorsDeepak K. Rajpal13
Estimated H-index: 13
(GlaxoSmithKline)
The objective of this study was to test a topical formulation of EPHX2 inhibitor, GSK2256294, in a dermal wound diabetic (db/db) mouse model. Comparisons were made between groups treated with EPHX2 inhibitor, matching vehicle control and a currently approved treatment for diabetic ulcers, becaplermin/Regranex, as a positive control which is highly efficacious in this model. Leptin receptor-deficient (db/db) male mice were sequentially assigned to treatment groups (N=10 per group) based on blood ...
Source Cite
Published on Mar 4, 2019in Expert Opinion on Drug Discovery 4.69
Vinaya Vijayan (GlaxoSmithKline), Andrew D. Rouillard1
Estimated H-index: 1
(GlaxoSmithKline)
+ 1 AuthorsPankaj K. Agarwal59
Estimated H-index: 59
(GlaxoSmithKline)
Source Cite
Published on Mar 1, 2019in Drug Discovery Today 6.85
Michal Magid-Slav7
Estimated H-index: 7
+ 1 AuthorsPankaj K. Agarwal59
Estimated H-index: 59
Genome-wide association studies (GWAS) have made considerable progress and there is emerging evidence that genetics-based targets can lead to 28% more launched drugs. We analyzed 1589 GWAS across 1456 pathways to translate these often imprecise genetic loci into therapeutic hypotheses for 182 diseases. These pathway-based genetic targets were validated by testing whether current drug targets were enriched in the pathway space for the same indication. Remarkably, 30% of diseases had significantly...
Source Cite
Published on Jan 1, 2019
Shivani Agarwal1
Estimated H-index: 1
(IMS Engineering College),
Vijander Singh13
Estimated H-index: 13
(University of Delhi)
+ 1 AuthorsAsha Rani9
Estimated H-index: 9
(University of Delhi)
Prediction of protein secondary structure plays a vital role in structural biology. Computational methodology is the initial step in bioinformatics to predict the 3-D secondary structure from a primary sequence and structure homology. This problem lies in the category of NP problem, and thus its time and space complexity is very high. In this paper, in a model for secondary structure prediction of proteins using sliding window and MADALINE, a multilayer feedforward network is proposed. The algor...
Source Cite
12345678910