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Staffan Magnusson
Aarhus University
Molecular biologyChemistryMacroglobulinBiochemistryProtein primary structure
43Publications
26H-index
2,352Citations
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Publications 44
Newest
#1C M JonesH-Index: 4
#2D M WierzbickiH-Index: 5
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A comparison of the sequence of the subunit of human a2-macroglobulin (a2M; 1451 amino acid residues) with that of murine complement component pro-C3 (1639 ami- no acid residues) reveals eight extended regions of sequence similarity. These regions contain between 19% and 31% iden- tically placed residues and account for 75% and 67%, respec- tively, of the polypeptide chains of a2M and pro-C3. Published sequence data for complement component C4 show that seg- ments of this protein match well with...
#1Torben E. PetersenH-Index: 50
Last. Staffan MagnussonH-Index: 26
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Approximately one-half of the amino acid se- quence (911 amino acid residues out of 1,880 expected) for bovine plasma fibronectin (cold-insoluble globulin) has been determined. Three types of internal homology were identified, showing that a number of partial gene duplications (multiplications) have oc- curred during the evolution of this protein. Digestion of fibro- nectin with plasmin results in major fragments with molecular masses of 29, 170, 23, and 6 kilodaltons (kDal). The NH2-terminal 29...
#1Torben Halkier (AU: Aarhus University)H-Index: 7
#2H. Andersen (AU: Aarhus University)H-Index: 1
Last. Staffan Magnusson (AU: Aarhus University)H-Index: 26
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Abstract Histidine-rich glycoprotein was purified from bovine plasma and the identity of the protein confirmed through amino acid sequencing. Activated bovine factor XIIIa catalyzed the incorporation of 1 nmol of 1,4-[ 14 C]putrescine into 1 nmol of bovine histidine-rich glycoprotein, showing that histidine-rich glycoprotein has the ability to participate in transglutaminase-catalyzed reactions in vivo .
5 CitationsSource
#1Emoeke BendixenH-Index: 1
#2Torben HalkierH-Index: 7
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The complete primary structure of bovine β 2 -glycoprotein I was determined by a combination of cDNA and peptide sequencing. Bovine β 2 -glycoprotein I was purified from citrated plasma, and by sequencing selected peptides, the complete disulfide bridge patterns of the 11 disulfide bridges were established as well as the positions of the five asparagine-linked carbohydrate groups. Bovine β 2 -glycoprotein I comprises five mutually homologous domain or short consensus repeats, each containing two...
36 CitationsSource
#1Astrid B. Vestergaard (AU: Aarhus University)H-Index: 4
#2Hanne F. Andersen (AU: Aarhus University)H-Index: 1
Last. Torben Halkier (AU: Aarhus University)H-Index: 7
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Abstract Histidine-rich glycoprotein has been purified from bovine plasma employing two different purification procedures. The first procedure was one-step ion-exchange chromatography using phosphocellulose, while the second procedure involved fractionation using polyethyleneglycol 6000 followed by column chromatography employing CM-Sepharose and heparin-Sepharose. The effect of purified bovine histidine-rich glycoprotein on the contact activation of blood coagulation was studied in human plasma...
8 CitationsSource
#1Torben Halkier (AU: Aarhus University)H-Index: 7
#2Staffan Magnusson (AU: Aarhus University)H-Index: 26
Abstract The effect of the purified bovine plasma factor XIII b-chain on contact activation of blood coagulation was studied in human and bovine plasma using either an ellagic acid-phospholipid suspension (Cephotest) or dextran sulfate as activating surface. Contact activation was monitored by the generation of amidolytic activity towards a synthetic chromogenic substrate (S-2302) for factor XIIa and plasma kallikrein. The factor XIII b-chain, which is released from tetrameric factor XIII (a 2 b...
10 CitationsSource
#1Jannie FuhlendorffH-Index: 1
#2Inge ClemmensenH-Index: 27
Last. Staffan MagnussonH-Index: 26
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71 CitationsSource
#1J Fuhlendorff (AU: Aarhus University)
#2Inge Clemmensen (Hvidovre Hospital)H-Index: 27
Last. Staffan Magnusson (AU: Aarhus University)H-Index: 26
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Source
#1Karna Skorstengaard (AU: Aarhus University)H-Index: 9
#2Margit S. Jensen (AU: Aarhus University)H-Index: 3
Last. Staffan Magnusson (AU: Aarhus University)H-Index: 26
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The primary structure of the 2265 residues of bovine plasma fibronectin has been completed. The new sequences reported in this paper are residues 600–868 (269 residues), 1138–1217 (80 residues), 1518–1599 (82 residues) and 1868–2061 (194 residues). These sequences constitute six type III homology units and two non-homologous connecting strands. Thus, there are fifteen type III homology units in plasma fibronectin. Evidence for two of the three splice variants found in rat liver cells [Schwarzbau...
164 CitationsSource
#1Karen Vibe-Pedersen (AU: Aarhus University)H-Index: 6
#2Staffan Magnusson (AU: Aarhus University)H-Index: 26
Last. F.E. Baralle (University of Oxford)H-Index: 21
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Abstract We have sequenced that area of a human fibronectin gene clone which codes for a connecting strand separating the last two areas of the type III homology. The gene has a complex exon with two ‘AG’ acceptor sites. One of these can be used (exon subdivision). In addition 93 basepairs inside the exon are sometimes spliced out as an intron. This is the third differential splicing found in the fibronectin gene transcript and it represents a new type of differential splicing.
28 CitationsSource
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