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Charles Robin
University of Melbourne
GeneAlleleDrosophila melanogasterGeneticsBiology
45Publications
20H-index
2,876Citations
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Publications 46
Newest
#1Jack L Scanlan (University of Melbourne)H-Index: 1
#2Rebecca S. Gledhill-Smith (University of Melbourne)H-Index: 1
Last. Charles Robin (University of Melbourne)H-Index: 20
view all 4 authors...
The capacity to detoxify toxic compounds is essential for adaptation to the ecological niches of many organisms, especially insects. However, detoxification in insects is often viewed through the lens of mammalian detoxification research, even though the organ and enzyme systems involved have diverged for over half a billion years. Phosphorylation is a non-canonical phase II detoxification reaction that, among animals, occurs near exclusively in insects, but the enzymes responsible have never be...
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#1Helen Young (University of Melbourne)H-Index: 8
#2Shane DeneckeH-Index: 4
Last. Alexandre Fournier-Level (University of Melbourne)H-Index: 15
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Pesticides are now chronically found in numerous ecosystems incurring widespread toxic effects on multiple organisms. For insects, the larvae are very exposed to pesticide pollution and the acute effect of insecticides on larvae has been characterized in a range of species. However, the carry-on effects in adults of sublethal exposure occurring in larvae are not well characterized. Here, we use a collection of strains of Drosophila melanogaster differing in their larval resistance to a commonly ...
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#1Amol Bharat Ghodke (University of Melbourne)H-Index: 2
#2Robert T. Good (University of Melbourne)H-Index: 21
Last. Charles Robin (University of Melbourne)H-Index: 20
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Myzus persicae is a major pest of many crops including canola and Brassica vegetables, partly because it vectors plant viruses. Previously it has been reported that double-stranded RNA delivered to aphids by injection, artificial diet or transgenic plants has knocked down target genes and caused phenotypic effects. While these studies suggest that RNA interference (RNAi) might be used to suppress aphid populations, none have shown effects sufficient for field control. The current study analyses ...
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#1Yao-ban Chan (University of Melbourne)H-Index: 8
#2Charles Robin (University of Melbourne)H-Index: 20
Abstract The phylogenetic trees of genes and the species which they belong to are similar, but distinct due to various evolutionary processes which affect genes but do not create new species. Reconciliations map the gene tree into the species tree, explaining the discrepancies by events including gene duplications and losses. However, when duplicate genes undergo recombination (a phenomenon known as paralog exchange, or non-allelic homologous recombination), the phylogeny of the genes becomes a ...
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#1Llewellyn Green (University of Melbourne)H-Index: 3
#2Paul Battlay (University of Melbourne)H-Index: 5
Last. Charles Robin (University of Melbourne)H-Index: 20
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Insecticide resistance is a paradigm of microevolution, and insecticides are responsible for the strongest cases of recent selection in the genome of Drosophila melanogaster . Here we use a naive population and a novel insecticide class to examine the ab initio genetic architecture of a potential selective response. Genome-wide association studies (GWAS) of chlorantraniliprole susceptibility reveal variation in a gene of major effect, Stretchin Myosin light chain kinase ( Strn-Mlck ), which we v...
3 CitationsSource
#1Alexandre Fournier-Level (University of Melbourne)H-Index: 15
#2Robert T. Good (University of Melbourne)H-Index: 21
Last. Charles Robin (University of Melbourne)H-Index: 20
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Imidacloprid, the world’s most used insecticide, has caused considerable controversy due to harmful effects on non-pest species and increasing evidence showing that insecticides have become the primary selective force in many insect species. The genetic response to insecticides is heterogeneous across populations and environments, leading to more complex patterns of genetic variation than previously thought. This motivated the investigation of imidacloprid resistance at different temperatures in...
3 CitationsSource
#1Charles Robin (University of Melbourne)H-Index: 20
#2Paul Battlay (University of Melbourne)H-Index: 5
Last. Alexandre Fournier-Level (University of Melbourne)H-Index: 15
view all 3 authors...
If we are to fully comprehend the evolution of insect diversity at a genomic level we need to understand how natural selection can alter genetically encoded characters within populations. Genetic association panels have the potential to be standard bearers in this endeavour. They enable the mapping of phenotypes to genotypes at unprecedented resolution while simultaneously providing population genomic samples that can be interrogated for the tell-tale signs of selection. Analyses of these panels...
2 CitationsSource
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#1Caitlyn Perry (University of Melbourne)H-Index: 1
#2Jack L Scanlan (University of Melbourne)H-Index: 1
Last. Charles Robin (University of Melbourne)H-Index: 20
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Several hundred insect genome assemblies are already publicly available, and this total grows on a weekly basis. A major challenge now confronting insect science is how best to use genomic data to improve our understanding of insect biology. We consider a framework for genome analysis based on functional affiliation, i.e. groups of genes involved in the same biological process or pathway, and explore how such an approach furthers our understanding of several aspects of insect phenotype. We antic...
1 CitationsSource
#1S.V. Song (University of Melbourne)H-Index: 1
#2Craig Anderson (Western General Hospital)H-Index: 7
Last. Charles Robin (University of Melbourne)H-Index: 20
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Over the last 40 years, many types of population genetic markers have been used to assess the population structure of the pest moth species Helicoverpa armigera. While this species is highly vagile, there is evidence of inter-continental population structure. Here, we examine Z-chromosome molecular markers within and between Chinese and Australian populations. Using 1352 polymorphic sites from 40 Z-linked loci, we compared two Chinese populations of moths separated by 700 km and found virtually ...
1 CitationsSource
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