Scott A. Halperin
Publications 225
Abstract Background Streptococcus pyogenes (group A Streptococcus, Strep A) is a widespread pathogen that continues to pose a significant threat to human health. The development of a Strep A vaccine remains an unmet global health need. One of the major vaccine strategies is the use of M protein, which is a primary virulence determinant and protective antigen. Multivalent recombinant M protein vaccines are being developed with N-terminal M peptides that contain opsonic epitopes but do not contain...
Abstract Background Pertussis immunization during pregnancy is recommended in many countries. Data from large randomized controlled trials are needed to assess the immunogenicity, reactogenicity and safety of this approach. Methods This phase IV, observer-blind, randomized, placebo-controlled, multicenter trial assessed immunogenicity, transplacental transfer of maternal pertussis antibodies, reactogenicity and safety of a reduced-antigen-content diphtheria-tetanus-three-component acellular pert...
Abstract Background Pertussis immunization during pregnancy results in high pertussis antibody concentrations in young infants but may interfere with infant immune responses to post-natal immunization. Methods This phase IV, multi-country, open-label study assessed the immunogenicity and safety of infant primary vaccination with DTaP-HepB-IPV/Hib and 13-valent pneumococcal conjugate vaccine (PCV13). Enrolled infants (6–14 weeks old) were born to mothers who were randomized to receive reduced-ant...
1 CitationsSource
#1Joanne M. Langley (Nova Scotia Health Authority)H-Index: 8
Last.Pierre Savard (Laval University)H-Index: 14
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#1Shelly Bolotin (U of T: University of Toronto)H-Index: 9
#2Alberto Severini (UM: University of Manitoba)H-Index: 17
Last.Natasha S. CrowcroftH-Index: 21
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ABSTRACTCanada eliminated measles in 1998. We conducted a sero-epidemiology study to estimate population immunity to measles in the province of Ontario, Canada and to identify groups at higher risk...
1 CitationsSource
#1Trushar R. Patel (U of L: University of Lethbridge)H-Index: 18
#2Keith R. FowkeH-Index: 35
Last.Curtis Cooper (U of O: University of Ottawa)H-Index: 174
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In March 2018, the Canadian Association for HIV Research (CAHR) and Canadian Foundation for Infectious Diseases (CFID) collaborated to conduct a workshop targeted to mid-career virology researchers...
#1Scott A. Halperin (Dal: Dalhousie University)H-Index: 41
#2Catherine Donovan (MUN: Memorial University of Newfoundland)H-Index: 4
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1 CitationsSource
#1Horace Wong (U of T: University of Toronto)H-Index: 5
#2Corinne Moss (U of T: University of Toronto)
Last.Anna Taddio (U of T: University of Toronto)H-Index: 49
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ABSTRACTObjectives: Recommendations regarding the need to use alcohol prior to vaccine injections are inconsistent and based on low-level evidence. The objective was to assess the effectiveness of alcohol in reducing local skin reactions and infection post-vaccination.Methods: Randomized controlled trial in a pediatric clinic. A research assistant cleansed the skin with alcohol at (swab group) or adjacent to (control group) the pre-defined injection site(s). Clinicians, parents and children were...
Abstract Objective Influenza vaccine uptake among Canadian pregnant individuals is suboptimal. Failure to incorporate vaccination into routine prenatal care and a lack of recommendations from healthcare providers are recognized as barriers to vaccination. The aim of this study was to assess Canadian maternity care providers' knowledge, attitudes, and practices regarding influenza vaccination in pregnancy. Methods A cross-sectional Web-based questionnaire was sent during July and August 2017 to f...
1 CitationsSource