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Seung Joon Baek
Seoul National University
186Publications
43H-index
5,691Citations
Publications 186
Newest
Published on Aug 1, 2019in Biochemical and Biophysical Research Communications2.71
Jae-Hak Lee8
Estimated H-index: 8
(SNU: Seoul National University),
Ilju Kim (SNU: Seoul National University)+ 1 AuthorsSeung Joon Baek43
Estimated H-index: 43
(SNU: Seoul National University)
Abstract Non-steroidal anti-inflammatory drug activated gene-1 (NAG-1), also known as growth differentiation factor 15 (GDF15), is a TGF-β (transforming growth factor beta) superfamily protein with a distinctive secretion pathway. NAG-1 is associated with multiple diseases including cancer, wherein it plays a role in both pro- and anti-cancer activities. We previously reported that NAG-1 is translocated to different subcellular compartments and its activity depends on its localization. In this p...
Published on Jun 1, 2019in Pharmacology & Therapeutics9.40
Seung Joon Baek43
Estimated H-index: 43
(SNU: Seoul National University),
Thomas E. Eling64
Estimated H-index: 64
(RTP: Research Triangle Park),
Thomas E. Eling1
Estimated H-index: 1
(RTP: Research Triangle Park)
Abstract Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. Both the intracellular GDF15 and the circulating mature GDF15 are implicated in biological processes, such as energy homeostasis and body weight regulation. Although there have b...
Published on May 1, 2019in Anticancer Research1.94
Yongdae Yoon1
Estimated H-index: 1
,
Bonghye Ku + 2 AuthorsSeung Joon Baek43
Estimated H-index: 43
Published on Mar 1, 2019in Food Biophysics2.41
Huaiqiong Chen11
Estimated H-index: 11
(UT: University of Tennessee),
Yongguang Guan11
Estimated H-index: 11
(UT: University of Tennessee)
+ 1 AuthorsQixin Zhong31
Estimated H-index: 31
(UT: University of Tennessee)
Caffeic acid phenethyl ester (CAPE) has high cytotoxicity against various cancer cells but has low water solubility and poor bioavailability. The objective of this work was to study a fully-dilutable oil-in-water microemulsion as a delivery vehicle of CAPE and the impacts on cellular uptake and expression of relevant proteins. Up to 3.30% w/w CAPE was dissolved in the microemulsion with droplets smaller than 20 nm and stable in 180 days. CAPE in the microemulsion had the significantly increased ...
Published on Sep 26, 2018in Oncology Letters1.87
Nadda Chaichanasak1
Estimated H-index: 1
(SNU: Seoul National University),
Pleumchitt Rojanapanthu7
Estimated H-index: 7
(Thammasat University)
+ 6 AuthorsSeung Joon Baek43
Estimated H-index: 43
(SNU: Seoul National University)
Published on Sep 19, 2018in International Journal of Molecular Sciences4.18
Viviane Seba2
Estimated H-index: 2
,
G. F. da Silva8
Estimated H-index: 8
+ 5 AuthorsMozart Marins8
Estimated H-index: 8
Osteosarcoma (OS) is a primary malignant bone tumor that mainly affects children, adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy since the development of metastatic disease due to drug resistance remains the most important cause of death from this cancer. Considering the severe side effects of current OS chemotherapy, the identification of anti-metastatic drugs with reduced toxicity is of great interest. Chalcones are polyphenols with a basic structu...
Published on Aug 17, 2018in PLOS ONE2.78
G. F. da Silva8
Estimated H-index: 8
,
Mozart Marins8
Estimated H-index: 8
+ 11 AuthorsBeatriz de Carvalho Marques2
Estimated H-index: 2
(UNESP: Sao Paulo State University)
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-chalcone exhibits superior inhibitory activity in cancer cell growth as shown via in vitro assays, and exerts anti-cancerous effects via the activation of the p53 tumor suppressor protein. Thus, characterization of the specific mechanisms, by wh...
Published on Aug 13, 2018in Molecules3.06
Tatiana Takahasi Komoto3
Estimated H-index: 3
,
Tayná Minervina Bernardes + 6 AuthorsAna Lúcia Fachin17
Estimated H-index: 17
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licoc...
Published on Aug 2, 2018in Water2.52
Yong Kown , Seung Joon Baek43
Estimated H-index: 43
+ 4 AuthorsKyung Hwa Cho21
Estimated H-index: 21
Published on Jun 29, 2018in International Journal of Molecular Sciences4.18
Felipe Teixeira Lima1
Estimated H-index: 1
,
Viviane Seba2
Estimated H-index: 2
+ 7 AuthorsMozart Marins10
Estimated H-index: 10
Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent in human osteosarcoma cell lines U2OS, MG-63, and Saos-2. CH-5 inhibited cell viability at lower concentrations than curcumin, leading to the induction of apoptosis. The cellular levels of the transcription factors p53 and Sp1 affect the expression of cellular pathways that le...
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