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Haodi Wu
Stanford University
Induced pluripotent stem cellCardiologyMedicineBiologyCell biology
51Publications
20H-index
1,383Citations
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Publications 55
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#1Qing Liu (Stanford University)H-Index: 3
#2Haodi Wu (Stanford University)H-Index: 20
Last. David Marciano (Stanford University)H-Index: 18
view all 27 authors...
Maternal drug exposure during pregnancy increases the risks of developmental cardiotoxicity, leading to congenital heart defects (CHDs). In this study, we used human stem cells as an in-vitro system to interrogate the mechanisms underlying drug-induced toxicity during cardiomyocyte differentiation, including anticancer tyrosine kinase inhibitor (TKI) drugs (imatinib, sunitinib, and vandetanib). H1-ESCs were treated with these drugs at sublethal levels during cardiomyocyte differentiation. We fou...
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#1Ping Wang (PKU: Peking University)H-Index: 4
#1Pingzhang Wang (PKU: Peking University)H-Index: 11
Last. L Y Tao
view all 6 authors...
OBJECTIVE: To explore the screening value of osteoporosis self-assessment tool for Asians (OSTA) and the optimal cut-off value in Chinese healthy physical examination population. METHODS: We selected a healthy physical examination population for bone mineral density screening at the Health Examination Center in Peking University Third Hospital from 2013 to 2016. Quantitative ultrasound (QUS) results were used as the gold standard, and T value
#1Haodi Wu (Stanford University)H-Index: 20
#2Huaxiao Yang (Stanford University)H-Index: 10
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 13 authors...
5 CitationsSource
#1Alexa Wnorowski (Stanford University)H-Index: 3
#2Arun SharmaH-Index: 26
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 13 authors...
Summary With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study the effects of microgravity on cell-level cardiac function and gene expression. The hiPSC-CMs were cultured aboard the ISS for 5.5 weeks and their gene expression, structure, and functions were compared with ground control hiPS...
2 CitationsSource
#1Nadjet Belbachir (Stanford University)H-Index: 1
#2Vincent Portero (University of Nantes)H-Index: 7
Last. Solena Le Scouarnec (University of Nantes)H-Index: 5
view all 33 authors...
AIMS: The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to ventricular arrhythmias. Despite considerable efforts, its genetic basis and cellular mechanisms remain largely unknown. The objective of this study was to identify a new susceptibility gene for BrS through familial investigation. METHODS AND RESULTS: Whole-exome sequencing performed in a three-generation pedigree with five affected members allowed the identification of one rare non-synonymous substitution (p.R211H...
2 CitationsSource
#1Hao Zhang (Cardiovascular Institute of the South)H-Index: 1
#2Lei Tian (Cardiovascular Institute of the South)H-Index: 4
Last. Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 8 authors...
Rationale: Activated fibroblasts are the major cell type that secretes excessive extracellular matrix in response to injury, contributing to pathological fibrosis and leading to organ failure. Effe...
2 CitationsSource
#1Jae Cheol LeeH-Index: 23
#2Vittavat Termglinchan (Cardiovascular Institute of the South)H-Index: 9
Last. Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 24 authors...
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Electrophysiological studies showed that the mutant iPSC-CMs displayed aberrant calcium homeostasis that led to arrhyt...
5 CitationsSource
#1Divya C. Kernik (UC Davis: University of California, Davis)H-Index: 1
#2Stefano Morotti (UC Davis: University of California, Davis)H-Index: 12
Last. Colleen E. Clancy (UC Davis: University of California, Davis)H-Index: 32
view all 10 authors...
4 CitationsSource
#1Joe Z. Zhang (Stanford University)H-Index: 4
#2Vittavat Termglinchan (Stanford University)H-Index: 9
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 17 authors...
Summary The diversity of cardiac lineages contributes to the heterogeneity of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs). Here, we report the generation of a hiPSC TBX5Clover2 and NKX2-5TagRFP double reporter to delineate cardiac lineages and isolate lineage-specific subpopulations. Molecular analyses reveal that four different subpopulations can be isolated based on the differential expression of TBX5 and NKX2-5, TBX5+NKX2-5+, TBX5+NKX2-5−, TBX5−NKX2-5+, and TBX5−N...
4 CitationsSource
#1Younghee OhH-Index: 2
#2Yunhee Park (Stanford University)H-Index: 1
Last. Michael Z. Lin (Stanford University)H-Index: 40
view all 10 authors...
Fluorescent indicators are used widely to visualize calcium dynamics downstream of membrane depolarization or G-protein-coupled receptor activation, but are poorly suited for non-invasive imaging in mammals. Here, we report a bright calcium-modulated bioluminescent indicator named Orange CaMBI (Orange Calcium-modulated Bioluminescent Indicator). Orange CaMBI reports calcium dynamics in single cells and, in the context of a transgenic mouse, reveals calcium oscillations in whole organs in an enti...
1 CitationsSource
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