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Haodi Wu
Stanford University
47Publications
18H-index
1,171Citations
Publications 47
Newest
#1Divya C. Kernik (UC Davis: University of California, Davis)
#2Stefano Morotti (UC Davis: University of California, Davis)H-Index: 10
Last.Colleen E. Clancy (UC Davis: University of California, Davis)H-Index: 29
view all 10 authors...
#1Hao Zhang (Stanford University)
#2Lei Tian (Stanford University)H-Index: 2
Last.Joseph C. Wu (Stanford University)H-Index: 87
view all 8 authors...
Rationale: Activated fibroblasts are the major cell type that secrete excessive extracellular matrix in response to injury, contributing to pathological fibrosis and leading to organ failure. Effec...
#1Jaecheol LeeH-Index: 10
#2Vittavat Termglinchan (Cardiovascular Institute of the South)H-Index: 9
Last.Haodi Wu (Cardiovascular Institute of the South)H-Index: 18
view all 24 authors...
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Electrophysiological studies showed that the mutant iPSC-CMs displayed aberrant calcium homeostasis that led to arrhyt...
#1Young-Hee OhH-Index: 2
#2Yunhee Park (Stanford University)
Last.Michael Z. Lin (Stanford University)H-Index: 38
view all 10 authors...
Fluorescent indicators are used widely to visualize calcium dynamics downstream of membrane depolarization or G-protein-coupled receptor activation, but are poorly suited for non-invasive imaging in mammals. Here, we report a bright calcium-modulated bioluminescent indicator named Orange CaMBI (Orange Calcium-modulated Bioluminescent Indicator). Orange CaMBI reports calcium dynamics in single cells and, in the context of a transgenic mouse, reveals calcium oscillations in whole organs in an enti...
#1Joe Z. Zhang (Stanford University)H-Index: 3
#2Vittavat Termglinchan (Stanford University)H-Index: 9
Last.Vicky Y. Wang (UCSF: University of California, San Francisco)H-Index: 7
view all 17 authors...
Summary The diversity of cardiac lineages contributes to the heterogeneity of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs). Here, we report the generation of a hiPSC TBX5 Clover2 and NKX2-5 TagRFP double reporter to delineate cardiac lineages and isolate lineage-specific subpopulations. Molecular analyses reveal that four different subpopulations can be isolated based on the differential expression of TBX5 and NKX2-5, TBX5+NKX2-5+, TBX5+NKX2-5−, TBX5−NKX2-5+, and TBX5...
#1Ling Tang (ZJU: Zhejiang University)H-Index: 1
#2Fang Yao (Peking Union Medical College)H-Index: 1
Last.Jue Wang (ZJU: Zhejiang University)H-Index: 1
view all 16 authors...
Abstract Cardiac hypertrophy is an adaptive response against increased workload featuring by an increase in left ventricular mass and a thickening left ventricle wall. Here, we showed the expression of transient receptor potential canonical 1 (TRPC1) is higher in hearts of patients with hypertrophic cardiomyopathy (HCM) or heart failure (HF) than that of normal hearts. To better understand the mechanisms of TRPC1 in regulating cellular hypertrophy of human-based cardiomyocytes, we generated huma...
#1Ning Ma (Cardiovascular Institute of the South)H-Index: 3
#2Joe Z. Zhang (Cardiovascular Institute of the South)H-Index: 3
Last.Rajani Shrestha (Cardiovascular Institute of the South)H-Index: 3
view all 14 authors...
Background: The progression toward low-cost and rapid next-generation sequencing has uncovered a multitude of variants of uncertain significance (VUS) in both patients and asymptomatic “healthy” in...
#1Jared M. ChurkoH-Index: 23
#2Priyanka Garg (Cardiovascular Institute of the South)H-Index: 5
Last.Kashish Chetal (Cincinnati Children's Hospital Medical Center)H-Index: 4
view all 17 authors...
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a powerful tool for human disease modeling and therapeutic testing. However, their use remains limited by their immaturity and heterogeneity. To characterize the source of this heterogeneity, we applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time during hiPSC cardiac differentiation and in the adult heart. Using integrated transcriptomic and splicing analysis, more than half a dozen d...
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