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Jennifer M. Nicholas
University of London
PsychiatryPsychologyFrontotemporal dementiaDiabetes mellitusMedicine
141Publications
20H-index
1,831Citations
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Publications 145
Newest
#1Cassidy M. FifordH-Index: 3
#3Carole H. SudreH-Index: 9
Last. Owen CarmichaelH-Index: 42
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#1Katrina M. Moore (UCL: University College London)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last. Daniel H. GeschwindH-Index: 129
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Summary Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods In this international, retrospective cohort study, we col...
2 CitationsSource
#1Christopher A. Lane (UCL: University College London)H-Index: 4
#2Josephine Barnes (UCL: University College London)H-Index: 41
Last. Jonathan M. Schott (UCL: University College London)H-Index: 49
view all 21 authors...
Importance Midlife vascular risk burden is associated with late-life dementia. Less is known about if and how risk exposure in early adulthood influences late-life brain health. Objective To determine the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and pathology using measures of white matter–hyperintensity volume, β-amyloid load, and whole-brain and hippocampal volumes. Design, Setting, and Participants This prospective longitudin...
2 CitationsSource
#1Thomas D. Parker (UCL Institute of Neurology)H-Index: 4
#2David M. Cash (UCL Institute of Neurology)H-Index: 26
Last. Jonathan M. Schott (UCL Institute of Neurology)H-Index: 49
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Background Hearing impairment may be a modifiable risk factor for dementia. However, it is unclear how hearing associates with pathologies relevant to dementia in preclinical populations. Methods Data from 368 cognitively healthy individuals born during 1 week in 1946 (age range 69.2–71.9 years), who underwent structural MRI, 18F-florbetapir positron emission tomography, pure tone audiometry and cognitive testing as part of a neuroscience substudy the MRC National Survey of Health and Developmen...
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#1Kirsty LuH-Index: 2
Last. Jonathan M. SchottH-Index: 49
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Objective To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a substudy of the Medical Research Council National Survey of Health and Development. Methods A total of 502 individuals born in the same week in 1946 underwent cognitive assessment at age 69–71 years, including an adapted version of the PACC and a test of nonverbal rea...
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#1Kristin V. Veighey (University Hospital Southampton NHS Foundation Trust)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last. Raymond J. MacAllister (Dorset County Hospital NHS Foundation Trust)H-Index: 45
view all 11 authors...
Abstract Background The REnal Protection Against Ischaemia–Reperfusion in transplantation (REPAIR) RCT examined whether remote ischaemic preconditioning (RIPC) improved renal function after living-donor kidney transplantation. The primary endpoint, glomerular filtration rate (GFR), quantified by iohexol at 12 months, suggested that RIPC may confer longer-term benefit. Here, we present yearly follow-up data of estimated GFR for up to 5 yr after transplantation. Methods In this double-blind, facto...
1 CitationsSource
#1Thomas D. ParkerH-Index: 4
#2David M. CashH-Index: 26
Last. Jonathan M. SchottH-Index: 49
view all 19 authors...
Background The human hippocampus comprises a number of interconnected histologically and functionally distinct subfields, which may be differentially influenced by cerebral pathology. Automated techniques are now available that estimate hippocampal subfield volumes using in vivo structural MRI data. To date, research investigating the influence of cerebral β-amyloid deposition—one of the earliest hypothesised changes in the pathophysiological continuum of Alzheimer’s disease—on hippocampal subfi...
1 CitationsSource
#1Derek J. HausenloyH-Index: 71
#2Rajesh K. Kharbanda (University of Oxford)H-Index: 17
Last. Lucy CollierH-Index: 1
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Summary Background Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. Methods We did an international investigator-initiated, prospective, s...
20 CitationsSource
#1Christopher A. Lane (UCL: University College London)H-Index: 4
#2Josephine Barnes (UCL: University College London)H-Index: 41
Last. Jonathan M. Schott (UCL: University College London)H-Index: 49
view all 25 authors...
Summary Background Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated through amyloid or vascular-related mechanisms are poorly understood. We aimed to identify if, and when, blood pressure or change in blood pressure during adulthood were associated with late-life brain structure, pathology, and cognition. Methods Participants were from Insight 46, a neuroscience substudy of the ongoing longi...
6 CitationsSource
#1Katrina M. MooreH-Index: 1
Last. J. D. RohrerH-Index: 1
view all 11 authors...
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